(52 nodes) Regulation of organ growth network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	STK4	Serine/threonine-protein kinase 4 isoform X1. (435 aa)
	YBX3	Y-box-binding protein 3 isoform X1. (264 aa)
	TBX20	T-box transcription factor TBX20. (449 aa)
	DUSP9	Dual specificity phosphatase 9. (382 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X4. (488 aa)
	FXN	Frataxin, mitochondrial. (211 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1299 aa)
	LATS2	Large tumor suppressor kinase 2. (992 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	SAV1	Protein salvador homolog 1. (385 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
	GSK3A	Glycogen synthase kinase-3 alpha. (483 aa)
	ENSTTRP00000007731	annotation not available (287 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (196 aa)
	EDN1	Endothelin-1. (202 aa)
	LATS1	Serine/threonine-protein kinase LATS1. (958 aa)
	WWC3	Protein WWC3 isoform X1. (1083 aa)
	GLI1	Zinc finger protein GLI1. (1106 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	BMP10	Bone morphogenetic protein 10. (423 aa)
	GATA6	Transcription factor GATA-6. (592 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
	RAG2	V(D)J recombination-activating protein 2. (527 aa)
	ANKRD26	Ankyrin repeat domain-containing protein 26-like isoform X2. (1450 aa)
	MEIS2	Homeobox protein Meis2 isoform X1. (345 aa)
	FGF8	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
	WWC1	Protein KIBRA. (1118 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (665 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
	IGF1	Insulin-like growth factor 1 transcript variant X4. (194 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	TBX2	T-box transcription factor TBX2. (703 aa)
	ZFPM2	Zinc finger protein ZFPM2. (1148 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
	TBX5	T-box transcription factor TBX5. (519 aa)
	PI16	Peptidase inhibitor 16; Belongs to the CRISP family. (462 aa)
	PIM1	Serine/threonine-protein kinase pim-1. (255 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (361 aa)
	PROX1	Prospero homeobox protein 1. (744 aa)
	TP73	Tumor protein p73 isoform X4. (638 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X1. (472 aa)
	JARID2	Protein Jumonji. (1235 aa)
	FLVCR1	Feline leukemia virus subgroup C receptor-related protein 1 isoform X1. (470 aa)
	MAEL	Protein maelstrom homolog isoform X1. (424 aa)
	STK3	Serine/threonine-protein kinase 3 isoform X1. (480 aa)
	ACACB	acetyl-CoA carboxylase 2. (2474 aa)
	WWC2	Protein WWC2 isoform X1. (1145 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	PIM1	ENSTTRP00000006049	ENSTTRP00000001847	acetyl-CoA carboxylase 2.	Serine/threonine-protein kinase pim-1.	0.405
BCL2L11	MAPK11	ENSTTRP00000005763	ENSTTRP00000011666	Bcl-2-like protein 11 isoform X1.	Mitogen-activated protein kinase.	0.428
BMP10	BMPR1A	ENSTTRP00000012877	ENSTTRP00000007678	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.616
BMP10	GATA6	ENSTTRP00000012877	ENSTTRP00000012663	Bone morphogenetic protein 10.	Transcription factor GATA-6.	0.438
BMP10	TBX20	ENSTTRP00000012877	ENSTTRP00000016598	Bone morphogenetic protein 10.	T-box transcription factor TBX20.	0.416
BMP10	TBX5	ENSTTRP00000012877	ENSTTRP00000000924	Bone morphogenetic protein 10.	T-box transcription factor TBX5.	0.495
BMP10	TGFBR1	ENSTTRP00000012877	ENSTTRP00000012962	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.665
BMPR1A	BMP10	ENSTTRP00000007678	ENSTTRP00000012877	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.616
BMPR1A	YAP1	ENSTTRP00000007678	ENSTTRP00000011064	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transcriptional coactivator YAP1 isoform X4.	0.544
DUSP6	DUSP9	ENSTTRP00000015609	ENSTTRP00000011078	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity phosphatase 9.	0.497
DUSP6	MAPK11	ENSTTRP00000015609	ENSTTRP00000011666	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.812
DUSP9	DUSP6	ENSTTRP00000011078	ENSTTRP00000015609	Dual specificity phosphatase 9.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.497
DUSP9	MAPK11	ENSTTRP00000011078	ENSTTRP00000011666	Dual specificity phosphatase 9.	Mitogen-activated protein kinase.	0.892
EDN1	ENSTTRP00000007731	ENSTTRP00000005761	ENSTTRP00000007731	Endothelin-1.	annotation not available	0.690
EDN1	IGF1	ENSTTRP00000005761	ENSTTRP00000016330	Endothelin-1.	Insulin-like growth factor 1 transcript variant X4.	0.506
ENSTTRP00000007731	EDN1	ENSTTRP00000007731	ENSTTRP00000005761	annotation not available	Endothelin-1.	0.690
ENSTTRP00000007731	ERBB4	ENSTTRP00000007731	ENSTTRP00000009578	annotation not available	Receptor protein-tyrosine kinase.	0.921
ENSTTRP00000007731	FGF20	ENSTTRP00000007731	ENSTTRP00000011907	annotation not available	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
ENSTTRP00000007731	FGF8	ENSTTRP00000007731	ENSTTRP00000014158	annotation not available	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	0.584
ENSTTRP00000007731	GATA6	ENSTTRP00000007731	ENSTTRP00000012663	annotation not available	Transcription factor GATA-6.	0.485