(23 nodes) Mesodermal cell differentiation network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NODAL	Nodal homolog. (348 aa)
	FOXF1	Forkhead box F1. (372 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	KDM6A	Lysine-specific demethylase 6A isoform X4. (1346 aa)
	ENSTTRP00000006381	annotation not available (382 aa)
	HMGA2	High mobility group protein HMGI-C. (83 aa)
	ETV2	ETS translocation variant 2. (362 aa)
	SIX2	Homeobox protein SIX2. (168 aa)
	ENSTTRP00000000710	annotation not available (306 aa)
	ITGA2	Integrin alpha-2; Belongs to the integrin alpha chain family. (1178 aa)
	TBX6	T-box transcription factor 6. (435 aa)
	ITGA3	Integrin subunit alpha 3. (1068 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	ITGB4	Integrin beta-4. (1815 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
	TAL1	T-cell acute lymphocytic leukemia protein 1. (330 aa)
	KDM6B	Dynein heavy chain 2, axonemal. (1642 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	ITGA8	Integrin alpha-8; Belongs to the integrin alpha chain family. (1060 aa)
	INHBA	Inhibin beta A chain. (421 aa)
	HOXA11	Homeobox protein Hox-A11. (311 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENSTTRP00000000710	ENSTTRP00000008787	ENSTTRP00000000710	Bone morphogenetic protein 4.	annotation not available	0.799
BMP4	ENSTTRP00000006381	ENSTTRP00000008787	ENSTTRP00000006381	Bone morphogenetic protein 4.	annotation not available	0.708
BMP4	EYA1	ENSTTRP00000008787	ENSTTRP00000011780	Bone morphogenetic protein 4.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.438
BMP4	FOXF1	ENSTTRP00000008787	ENSTTRP00000005561	Bone morphogenetic protein 4.	Forkhead box F1.	0.555
BMP4	SMAD1	ENSTTRP00000008787	ENSTTRP00000007646	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.791
BMP4	TBX6	ENSTTRP00000008787	ENSTTRP00000005221	Bone morphogenetic protein 4.	T-box transcription factor 6.	0.562
ENSTTRP00000000710	BMP4	ENSTTRP00000000710	ENSTTRP00000008787	annotation not available	Bone morphogenetic protein 4.	0.799
ENSTTRP00000000710	ENSTTRP00000006381	ENSTTRP00000000710	ENSTTRP00000006381	annotation not available	annotation not available	0.493
ENSTTRP00000000710	NODAL	ENSTTRP00000000710	ENSTTRP00000002983	annotation not available	Nodal homolog.	0.539
ENSTTRP00000006381	BMP4	ENSTTRP00000006381	ENSTTRP00000008787	annotation not available	Bone morphogenetic protein 4.	0.708
ENSTTRP00000006381	ENSTTRP00000000710	ENSTTRP00000006381	ENSTTRP00000000710	annotation not available	annotation not available	0.493
ENSTTRP00000006381	SFRP2	ENSTTRP00000006381	ENSTTRP00000004282	annotation not available	Secreted frizzled-related protein 2.	0.964
ENSTTRP00000006381	TBX6	ENSTTRP00000006381	ENSTTRP00000005221	annotation not available	T-box transcription factor 6.	0.632
ETV2	TAL1	ENSTTRP00000002085	ENSTTRP00000011049	ETS translocation variant 2.	T-cell acute lymphocytic leukemia protein 1.	0.545
EYA1	BMP4	ENSTTRP00000011780	ENSTTRP00000008787	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Bone morphogenetic protein 4.	0.438
EYA1	ITGA8	ENSTTRP00000011780	ENSTTRP00000003655	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Integrin alpha-8; Belongs to the integrin alpha chain family.	0.405
EYA1	SIX2	ENSTTRP00000011780	ENSTTRP00000001018	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX2.	0.836
EYA1	TBX6	ENSTTRP00000011780	ENSTTRP00000005221	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	T-box transcription factor 6.	0.405
FOXF1	BMP4	ENSTTRP00000005561	ENSTTRP00000008787	Forkhead box F1.	Bone morphogenetic protein 4.	0.555
INHBA	SMAD1	ENSTTRP00000003401	ENSTTRP00000007646	Inhibin beta A chain.	Mothers against decapentaplegic homolog.	0.456