STRINGSTRING
GAMT GAMT TBX20 TBX20 TWF2 TWF2 PLXNA4 PLXNA4 IGF1 IGF1 GDF5 GDF5 GPR21 GPR21 PTPRS PTPRS CDKL3 CDKL3 RASAL1 RASAL1 DNM2 DNM2 NTN1 NTN1 DUSP6 DUSP6 KIAA0319 KIAA0319 HEY2 HEY2 SLC6A4 SLC6A4 WWC1 WWC1 SEMA4B SEMA4B NIPBL NIPBL EPHA7 EPHA7 ENSTTRP00000015206 ENSTTRP00000015206 TLL2 TLL2 CREB1 CREB1 SEMA6D SEMA6D ABL1 ABL1 SEMA4G SEMA4G CDKN1B CDKN1B FGF8 FGF8 RAI1 RAI1 ZP3 ZP3 CRABP2 CRABP2 MEIS2 MEIS2 ANKRD26 ANKRD26 COLQ COLQ CELF1 CELF1 RAG2 RAG2 JARID2 JARID2 PIK3CA PIK3CA DLL1 DLL1 MEGF8 MEGF8 FLVCR1 FLVCR1 MSTN MSTN MYOD1 MYOD1 SIX4 SIX4 SIX1 SIX1 TGFBR1 TGFBR1 BMP10 BMP10 MT3 MT3 BBS2 BBS2 CDKN1A CDKN1A NKD1 NKD1 GATA6 GATA6 PPIB PPIB GHSR GHSR MBD6 MBD6 GLI1 GLI1 SEMA4F SEMA4F HTRA2 HTRA2 FTO FTO FGF20 FGF20 BARHL2 BARHL2 MAPK11 MAPK11 MYOZ1 MYOZ1 PRKN PRKN BBS4 BBS4 SEMA5B SEMA5B DUSP9 DUSP9 YAP1 YAP1 PLXNA3 PLXNA3 SIN3A SIN3A EZR EZR SYT2 SYT2 NGF NGF DSCAM DSCAM PTCH1 PTCH1 VIL1 VIL1 TNR TNR FXN FXN WNT2 WNT2 SOX15 SOX15 ERBB4 ERBB4 ENSTTRP00000009560 ENSTTRP00000009560 PLS1 PLS1 EFNA5 EFNA5 ZFYVE27 ZFYVE27 AGR2 AGR2 LATS2 LATS2 ENSTTRP00000009296 ENSTTRP00000009296 CPNE9 CPNE9 SAV1 SAV1 SEMA3D SEMA3D DUSP10 DUSP10 ATRN ATRN PPARD PPARD BMP4 BMP4 CDH4 CDH4 INSR INSR SEMA3C SEMA3C LIMK1 LIMK1 OSTN OSTN SMO SMO ADRB2 ADRB2 GSK3A GSK3A ENSTTRP00000007731 ENSTTRP00000007731 RTN4R RTN4R BMPR1A BMPR1A YBX3 YBX3 SEMA7A SEMA7A SEMA4C SEMA4C SEMA3B SEMA3B SEMA3F SEMA3F STK4 STK4 NOTCH1 NOTCH1 SGPL1 SGPL1 SYT17 SYT17 POU4F2 POU4F2 DRD2 DRD2 STAT3 STAT3 STAT5A STAT5A LOC101329049 LOC101329049 SRF SRF SEMA6C SEMA6C IFRD2 IFRD2 ENSTTRP00000006381 ENSTTRP00000006381 WWC2 WWC2 STAT5B STAT5B ENSTTRP00000006301 ENSTTRP00000006301 ACACB ACACB STK3 STK3 MKKS MKKS TNKS2 TNKS2 PRLH PRLH MAEL MAEL BCL2L11 BCL2L11 EDN1 EDN1 LATS1 LATS1 WWC3 WWC3 ZMPSTE24 ZMPSTE24 PLAA PLAA GOLGA4 GOLGA4 WNT5A WNT5A LOC101323724 LOC101323724 SEMA3E SEMA3E MFSD2A MFSD2A BCL2 BCL2 CDKL5 CDKL5 BMPR2 BMPR2 SEMA5A SEMA5A SEMA6A SEMA6A DPYSL2 DPYSL2 MUL1 MUL1 PEX5 PEX5 ENSTTRP00000004523 ENSTTRP00000004523 RTN4 RTN4 TBX2 TBX2 ADRB1 ADRB1 SMAD7 SMAD7 GDF15 GDF15 CHD7 CHD7 MBD5 MBD5 AR AR ZFPM2 ZFPM2 ENSTTRP00000003732 ENSTTRP00000003732 MEF2C MEF2C SPART SPART DIP2B DIP2B RYK RYK WNT3 WNT3 SLC6A3 SLC6A3 GPAT4 GPAT4 NEDD4L NEDD4L TP73 TP73 PROX1 PROX1 SEMA4D SEMA4D ENSTTRP00000003143 ENSTTRP00000003143 SOCS2 SOCS2 APP APP SMURF1 SMURF1 DBNL DBNL FSTL4 FSTL4 NPY1R NPY1R CAPN3 CAPN3 UNC13A UNC13A CPNE5 CPNE5 MAP3K13 MAP3K13 SYT3 SYT3 MTM1 MTM1 SASH3 SASH3 PLAC8 PLAC8 NKX6-1 NKX6-1 PIM1 PIM1 PI16 PI16 LPAR3 LPAR3 GHRH GHRH IST1 IST1 SEMA6B SEMA6B SYT4 SYT4 LEP LEP LGMN LGMN MYCBP2 MYCBP2 SEMA4A SEMA4A RIMS1 RIMS1 SEMA3G SEMA3G SEMA3A SEMA3A TBX5 TBX5 IL7 IL7 CDK5 CDK5 FGF9 FGF9 ULK1 ULK1 SHTN1 SHTN1 GHRHR GHRHR GPAM GPAM SYT1 SYT1 ISLR2 ISLR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAMTLOW QUALITY PROTEIN: guanidinoacetate N-methyltransferase. (175 aa)
TBX20T-box transcription factor TBX20. (449 aa)
TWF2Twinfilin-2 isoform X1. (349 aa)
PLXNA4plexin-A4. (1859 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
GDF5Growth/differentiation factor 5. (489 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S-like. (1946 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (586 aa)
RASAL1rasGAP-activating-like protein 1 isoform X1. (801 aa)
DNM2Dynamin-2 isoform X4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
NTN1Netrin-1. (604 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
KIAA0319Dyslexia-associated protein KIAA0319 homolog. (1011 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (665 aa)
WWC1Protein KIBRA. (1118 aa)
SEMA4Bsemaphorin-4B isoform X1; Belongs to the semaphorin family. (827 aa)
NIPBLNipped-B protein. (2801 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
ENSTTRP00000015206annotation not available (554 aa)
TLL2Metalloendopeptidase. (954 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SEMA6Dsemaphorin-6D; Belongs to the semaphorin family. (1073 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (774 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (173 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
RAI1Retinoic acid induced 1. (1949 aa)
ZP3Zona pellucida sperm-binding protein 3. (474 aa)
CRABP2Cellular retinoic acid binding protein 2. (122 aa)
MEIS2Homeobox protein Meis2 isoform X1. (345 aa)
ANKRD26Ankyrin repeat domain-containing protein 26-like isoform X2. (1450 aa)
COLQAcetylcholinesterase collagenic tail peptide. (458 aa)
CELF1CUGBP Elav-like family member 1 isoform X7. (486 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
JARID2Protein Jumonji. (1235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2767 aa)
FLVCR1Feline leukemia virus subgroup C receptor-related protein 1 isoform X1. (470 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
SIX4Homeobox protein SIX4. (494 aa)
SIX1Homeobox protein SIX1. (284 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
MT3Keratin-associated protein 5-8; Belongs to the metallothionein superfamily. Type 1 family. (67 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
NKD1Protein naked cuticle homolog 1. (468 aa)
GATA6Transcription factor GATA-6. (592 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
MBD6methyl-CpG binding domain protein 6. (1005 aa)
GLI1Zinc finger protein GLI1. (1106 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (773 aa)
HTRA2Serine protease HTRA2, mitochondrial. (457 aa)
FTOAlpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
BARHL2barH-like 2 homeobox protein. (380 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MYOZ1Myozenin-1 isoform X1. (298 aa)
PRKN1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (465 aa)
BBS4Bardet-Biedl syndrome 4 protein. (516 aa)
SEMA5BSemaphorin 5B. (1138 aa)
DUSP9Dual specificity phosphatase 9. (382 aa)
YAP1Transcriptional coactivator YAP1 isoform X4. (488 aa)
PLXNA3plexin-A3. (1872 aa)
SIN3APaired amphipathic helix protein Sin3a isoform X1. (1211 aa)
EZREzrin isoform X1. (582 aa)
SYT2Synaptotagmin-2. (417 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
DSCAMDown syndrome cell adhesion molecule. (2113 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
VIL1Villin 1. (825 aa)
TNRtenascin-R. (1249 aa)
FXNFrataxin, mitochondrial. (211 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SOX15Transcription factor SOX-1. (175 aa)
ERBB4Receptor protein-tyrosine kinase. (1299 aa)
ENSTTRP00000009560annotation not available (199 aa)
PLS1Plastin-1. (628 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
ZFYVE27Protrudin isoform X1. (418 aa)
AGR2Anterior gradient protein 2 homolog. (182 aa)
LATS2Large tumor suppressor kinase 2. (992 aa)
ENSTTRP00000009296annotation not available (181 aa)
CPNE9Copine-9 isoform X2. (553 aa)
SAV1Protein salvador homolog 1. (385 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (480 aa)
ATRNAttractin isoform X1. (1418 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
CDH4Cadherin 4. (897 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
LIMK1LIM domain kinase 1. (561 aa)
OSTNOsteocrin. (128 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
ADRB2Beta-2 adrenergic receptor. (418 aa)
GSK3AGlycogen synthase kinase-3 alpha. (483 aa)
ENSTTRP00000007731annotation not available (287 aa)
RTN4RReticulon-4 receptor. (481 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
YBX3Y-box-binding protein 3 isoform X1. (264 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group). (663 aa)
SEMA4Csemaphorin-4C. (833 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (747 aa)
SEMA3FSemaphorin 3F. (784 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (435 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (406 aa)
SYT17Synaptotagmin-17 isoform X3. (474 aa)
POU4F2POU class 4 homeobox 2. (409 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (445 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
STAT5ASignal transducer and activator of transcription 5A. (794 aa)
LOC101329049Spectrin beta chain, non-erythrocytic 4-like. (2559 aa)
SRFSerum response factor isoform X2. (509 aa)
SEMA6CSemaphorin 6C. (966 aa)
IFRD2Interferon-related developmental regulator 2 isoform X2. (584 aa)
ENSTTRP00000006381annotation not available (382 aa)
WWC2Protein WWC2 isoform X1. (1145 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
ENSTTRP00000006301annotation not available (229 aa)
ACACBacetyl-CoA carboxylase 2. (2474 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (480 aa)
MKKSMcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (568 aa)
TNKS2Poly [ADP-ribose] polymerase. (1168 aa)
PRLHProlactin-releasing peptide. (79 aa)
MAELProtein maelstrom homolog isoform X1. (424 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (196 aa)
EDN1Endothelin-1. (202 aa)
LATS1Serine/threonine-protein kinase LATS1. (958 aa)
WWC3Protein WWC3 isoform X1. (1083 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PLAAPhospholipase A-2-activating protein. (794 aa)
GOLGA4Golgin subfamily A member 4 isoform X1. (2149 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
LOC101323724Oncomodulin; Belongs to the parvalbumin family. (88 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1 isoform X2. (510 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
CDKL5Cyclin-dependent kinase-like 5. (1010 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SEMA5Asemaphorin-5A. (1073 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1032 aa)
DPYSL2Dihydropyrimidinase-related protein 2. (571 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
PEX5Peroxisomal biogenesis factor 5 isoform X1. (639 aa)
ENSTTRP00000004523annotation not available (204 aa)
RTN4Reticulon. (1189 aa)
TBX2T-box transcription factor TBX2. (703 aa)
ADRB1Beta-1 adrenergic receptor. (467 aa)
SMAD7Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
GDF15Growth differentiation factor 15. (308 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X3. (2970 aa)
MBD5methyl-CpG-binding domain protein 5 isoform X1. (1728 aa)
ARAndrogen receptor. (886 aa)
ZFPM2Zinc finger protein ZFPM2. (1148 aa)
ENSTTRP00000003732annotation not available (574 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
SPARTSpartin isoform X1. (666 aa)
DIP2BDisco-interacting protein 2 homolog B isoform X2. (1574 aa)
RYKTyrosine-protein kinase RYK isoform X2. (559 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SLC6A3Solute carrier family 6 member 3. (617 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4 isoform X1. (454 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like isoform X3. (992 aa)
TP73Tumor protein p73 isoform X4. (638 aa)
PROX1Prospero homeobox protein 1. (744 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
ENSTTRP00000003143annotation not available (114 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
APPAmyloid beta A4 protein isoform X1. (763 aa)
SMURF1E3 ubiquitin-protein ligase. (738 aa)
DBNLDrebrin like. (429 aa)
FSTL4Follistatin-related protein 4. (833 aa)
NPY1RNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
CAPN3Calpain-3; Belongs to the peptidase C2 family. (822 aa)
UNC13AProtein unc-13 homolog A. (1702 aa)
CPNE5Copine-5 isoform X2. (588 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (964 aa)
SYT3Uncharacterized protein. (591 aa)
MTM1Myotubularin isoform X1. (603 aa)
SASH3SAM and SH3 domain-containing protein 3. (361 aa)
PLAC8Placenta-specific gene 8 protein. (75 aa)
NKX6-1Homeobox protein Nkx-6.1. (364 aa)
PIM1Serine/threonine-protein kinase pim-1. (255 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (462 aa)
LPAR3Lysophosphatidic acid receptor 3 isoform X5; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GHRHSomatoliberin isoform X2. (107 aa)
IST1IST1 homolog isoform X2. (364 aa)
SEMA6Bsemaphorin-6B-like. (677 aa)
SYT4Synaptotagmin-4 isoform X1. (424 aa)
LEPLeptin. (167 aa)
LGMNLegumain. (433 aa)
MYCBP2E3 ubiquitin-protein ligase MYCBP2 isoform X11. (4632 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
RIMS1Regulating synaptic membrane exocytosis protein 1 isoform X1. (1673 aa)
SEMA3GSemaphorin 3G. (765 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
TBX5T-box transcription factor TBX5. (519 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
CDK5Cyclin dependent kinase 5. (292 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1050 aa)
SHTN1Shootin-1 isoform X1. (602 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (420 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (824 aa)
SYT1Synaptotagmin-1. (366 aa)
ISLR2Immunoglobulin superfamily containing leucine-rich repeat protein 2. (632 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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