(37 nodes) Embryonic cranial skeleton morphogenesis network (Tursiops truncatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHST11	Carbohydrate sulfotransferase. (350 aa)
	WNT9B	Wnt family member 9B. (330 aa)
	GLI3	Transcriptional activator GLI3. (1580 aa)
	MMP16	Matrix metalloproteinase-16. (606 aa)
	NODAL	Nodal homolog. (348 aa)
	SMAD3	Mothers against decapentaplegic homolog 3. (291 aa)
	FGFR2	Fibroblast growth factor receptor. (811 aa)
	SIX4	Homeobox protein SIX4. (494 aa)
	EIF4A3	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (354 aa)
	SIX2	Homeobox protein SIX2. (168 aa)
	NIPBL	Nipped-B protein. (2801 aa)
	ALX3	Homeobox protein aristaless-like 3. (250 aa)
	SETD2	Histone-lysine N-methyltransferase SETD2. (2054 aa)
	FGF8	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
	WDR19	WD repeat-containing protein 19 isoform X1. (1335 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
	NDST1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (882 aa)
	TFAP2A	Transcription factor AP-2-alpha isoform X6. (439 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1040 aa)
	IFT140	Intraflagellar transport protein 140 homolog. (1391 aa)
	DLX2	Homeobox protein DLX-2. (281 aa)
	SLC39A1	Zinc transporter ZIP1. (324 aa)
	TBX15	T-box transcription factor TBX15. (602 aa)
	ENSTTRP00000009086	annotation not available (269 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (587 aa)
	HOXA2	Homeobox protein Hox-A2. (295 aa)
	PRRX1	Paired mesoderm homeobox protein 1. (164 aa)
	MTHFD1L	Monofunctional C1-tetrahydrofolate synthase, mitochondrial. (901 aa)
	PAX5	Paired box protein Pax-9 isoform X2. (391 aa)
	GRHL2	Grainyhead-like protein 2 homolog isoform X4. (619 aa)
	TULP3	Tubby-related protein 3 isoform X1; Belongs to the TUB family. (429 aa)
	MED12	Mediator of RNA polymerase II transcription subunit 12. (2173 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF8	ENSTTRP00000008787	ENSTTRP00000014158	Bone morphogenetic protein 4.	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	0.670
BMP4	FGFR2	ENSTTRP00000008787	ENSTTRP00000002030	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.550
BMP4	PDGFRA	ENSTTRP00000008787	ENSTTRP00000011756	Bone morphogenetic protein 4.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.579
BMP4	RUNX2	ENSTTRP00000008787	ENSTTRP00000006566	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.814
BMP4	SMAD3	ENSTTRP00000008787	ENSTTRP00000002846	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog 3.	0.749
BMP4	TGFBR1	ENSTTRP00000008787	ENSTTRP00000012962	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.835
DLX2	FGF8	ENSTTRP00000010784	ENSTTRP00000014158	Homeobox protein DLX-2.	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	0.440
FGF8	BMP4	ENSTTRP00000014158	ENSTTRP00000008787	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.670
FGF8	DLX2	ENSTTRP00000014158	ENSTTRP00000010784	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	Homeobox protein DLX-2.	0.440
FGF8	FGFR2	ENSTTRP00000014158	ENSTTRP00000002030	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.991
FGF8	GLI3	ENSTTRP00000014158	ENSTTRP00000003403	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	Transcriptional activator GLI3.	0.437
FGF8	LHX1	ENSTTRP00000014158	ENSTTRP00000008440	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	LIM/homeobox protein Lhx1.	0.425
FGF8	PDGFRA	ENSTTRP00000014158	ENSTTRP00000011756	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.934
FGF8	RUNX2	ENSTTRP00000014158	ENSTTRP00000006566	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.440
FGFR2	BMP4	ENSTTRP00000002030	ENSTTRP00000008787	Fibroblast growth factor receptor.	Bone morphogenetic protein 4.	0.550
FGFR2	FGF8	ENSTTRP00000002030	ENSTTRP00000014158	Fibroblast growth factor receptor.	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	0.991
FGFR2	PDGFRA	ENSTTRP00000002030	ENSTTRP00000011756	Fibroblast growth factor receptor.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.751
GLI3	FGF8	ENSTTRP00000003403	ENSTTRP00000014158	Transcriptional activator GLI3.	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	0.437
GLI3	IFT140	ENSTTRP00000003403	ENSTTRP00000011377	Transcriptional activator GLI3.	Intraflagellar transport protein 140 homolog.	0.561
GLI3	PDGFRA	ENSTTRP00000003403	ENSTTRP00000011756	Transcriptional activator GLI3.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.684