(48 nodes) Artery morphogenesis network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FOXF1	Forkhead box F1. (372 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	ACVRL1	Activin A receptor like type 1. (497 aa)
	ARID2	AT-rich interactive domain-containing protein 2 isoform X2. (1772 aa)
	TBX2	T-box transcription factor TBX2. (703 aa)
	SMAD7	Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7 isoform X3. (2970 aa)
	STRA6	Stimulated by retinoic acid gene 6 protein homolog. (664 aa)
	TFAP2B	Transcription factor AP-2-beta isoform X4. (360 aa)
	PROX1	Prospero homeobox protein 1. (744 aa)
	MYOCD	Myocardin isoform X1. (968 aa)
	APOB	Apolipoprotein B-100. (4551 aa)
	HAND2	Heart- and neural crest derivatives-expressed protein 2. (208 aa)
	HES1	Transcription factor HES-1. (280 aa)
	FOXH1	Forkhead box H1. (360 aa)
	EDNRA	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	ENG	Endoglin. (655 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
	SEC24B	Protein transport protein Sec24B. (1253 aa)
	NF1	Neurofibromin. (2814 aa)
	PKD2	Polycystin-2 isoform X2. (975 aa)
	FGF8	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
	ANGPTL3	Angiopoietin like 3. (460 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
	CITED2	Cbp/p300-interacting transactivator 2. (272 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
	PRDM1	PR domain zinc finger protein 1 isoform X1. (787 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
	NPRL3	Nitrogen permease regulator 3-like protein isoform X1. (569 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (750 aa)
	FOLR1	Folate receptor gamma. (251 aa)
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
	COL3A1	Collagen alpha-1(III) chain. (1464 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	LDLR	Low-density lipoprotein receptor. (842 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (316 aa)
	ADGRF5	Adhesion G protein-coupled receptor F5 isoform X3; Belongs to the G-protein coupled receptor 2 family. (1342 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
	SRF	Serum response factor isoform X2. (509 aa)
	FKBP10	FKBP prolyl isomerase 10. (574 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (4599 aa)
	PRRX1	Paired mesoderm homeobox protein 1. (164 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	EDN1	Endothelin-1. (202 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMP4	ENSTTRP00000004656	ENSTTRP00000008787	Activin A receptor like type 1.	Bone morphogenetic protein 4.	0.937
ACVRL1	BMPR1A	ENSTTRP00000004656	ENSTTRP00000007678	Activin A receptor like type 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.661
ACVRL1	BMPR2	ENSTTRP00000004656	ENSTTRP00000004697	Activin A receptor like type 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.974
ACVRL1	ENG	ENSTTRP00000004656	ENSTTRP00000015608	Activin A receptor like type 1.	Endoglin.	0.771
ACVRL1	SMAD7	ENSTTRP00000004656	ENSTTRP00000004100	Activin A receptor like type 1.	Mothers against decapentaplegic homolog 7 isoform X1.	0.798
ACVRL1	TGFBR1	ENSTTRP00000004656	ENSTTRP00000012962	Activin A receptor like type 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.612
ANGPTL3	APOB	ENSTTRP00000013182	ENSTTRP00000000072	Angiopoietin like 3.	Apolipoprotein B-100.	0.518
ANGPTL3	SEC24B	ENSTTRP00000013182	ENSTTRP00000015459	Angiopoietin like 3.	Protein transport protein Sec24B.	0.509
APOB	ANGPTL3	ENSTTRP00000000072	ENSTTRP00000013182	Apolipoprotein B-100.	Angiopoietin like 3.	0.518
APOB	APOE	ENSTTRP00000000072	ENSTTRP00000008256	Apolipoprotein B-100.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.861
APOB	LDLR	ENSTTRP00000000072	ENSTTRP00000009019	Apolipoprotein B-100.	Low-density lipoprotein receptor.	0.913
APOB	LRP2	ENSTTRP00000000072	ENSTTRP00000006193	Apolipoprotein B-100.	Low-density lipoprotein receptor-related protein 2.	0.682
APOE	APOB	ENSTTRP00000008256	ENSTTRP00000000072	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Apolipoprotein B-100.	0.861
APOE	LDLR	ENSTTRP00000008256	ENSTTRP00000009019	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Low-density lipoprotein receptor.	0.511
APOE	LRP2	ENSTTRP00000008256	ENSTTRP00000006193	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Low-density lipoprotein receptor-related protein 2.	0.886
ARID2	NF1	ENSTTRP00000004371	ENSTTRP00000014587	AT-rich interactive domain-containing protein 2 isoform X2.	Neurofibromin.	0.464
BMP4	ACVRL1	ENSTTRP00000008787	ENSTTRP00000004656	Bone morphogenetic protein 4.	Activin A receptor like type 1.	0.937
BMP4	BMPR1A	ENSTTRP00000008787	ENSTTRP00000007678	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.995
BMP4	BMPR2	ENSTTRP00000008787	ENSTTRP00000004697	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.986
BMP4	EYA1	ENSTTRP00000008787	ENSTTRP00000011780	Bone morphogenetic protein 4.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.438