STRINGSTRING
EDNRB EDNRB HAND2 HAND2 SEMA3G SEMA3G SEMA3A SEMA3A SLC9A1 SLC9A1 ANXA6 ANXA6 ENSTTRP00000000710 ENSTTRP00000000710 SH2B3 SH2B3 SFRP1 SFRP1 EZH2 EZH2 MAPK1 MAPK1 TBXT TBXT HTR2B HTR2B SEMA4B SEMA4B SETD2 SETD2 SEMA6D SEMA6D KIT KIT NELFB NELFB SEMA4G SEMA4G GPM6A GPM6A NOLC1 NOLC1 NRP2 NRP2 ALX1 ALX1 EXT1 EXT1 JARID2 JARID2 SIX1 SIX1 HOXD4 HOXD4 SHH SHH CITED2 CITED2 TGFB2 TGFB2 GATA6 GATA6 PEF1 PEF1 TCOF1 TCOF1 LRP6 LRP6 SEMA4F SEMA4F HIF1A HIF1A CYP26C1 CYP26C1 HOXB4 HOXB4 MSX1 MSX1 FZD1 FZD1 KBTBD8 KBTBD8 RADIL RADIL SMAD4 SMAD4 SEMA5B SEMA5B TAL1 TAL1 TP63 TP63 CDK6 CDK6 ECE2 ECE2 PSMD11 PSMD11 LAMA5 LAMA5 ISL1 ISL1 LOC101333926 LOC101333926 FOLR1 FOLR1 ERBB4 ERBB4 WNT10A WNT10A NRP1 NRP1 ITGB1 ITGB1 MLLT3 MLLT3 OSR1 OSR1 ENSTTRP00000009296 ENSTTRP00000009296 SEMA3D SEMA3D NRTN NRTN SHC4 SHC4 BATF BATF RDH10 RDH10 HESX1 HESX1 XRCC5 XRCC5 SEMA3C SEMA3C PTPRC PTPRC SETD6 SETD6 MED1 MED1 SMO SMO ERCC2 ERCC2 ENSTTRP00000007731 ENSTTRP00000007731 BMPR1A BMPR1A SEMA7A SEMA7A GSC GSC SEMA4C SEMA4C ACVR1 ACVR1 SEMA3B SEMA3B SEMA3F SEMA3F NOTCH1 NOTCH1 GBX2 GBX2 PUM1 PUM1 CDH2 CDH2 SRF SRF SEMA6C SEMA6C MTF2 MTF2 RUNX2 RUNX2 HOXA7 HOXA7 PHF19 PHF19 KLHL12 KLHL12 JAG1 JAG1 CTNNB1 CTNNB1 EDN1 EDN1 EFNB1 EFNB1 SOX8 SOX8 UFL1 UFL1 SOX9 SOX9 MAPK3 MAPK3 FOXO4 FOXO4 SEMA3E SEMA3E BCL2 BCL2 SEMA5A SEMA5A SEMA6A SEMA6A SOX10 SOX10 LMBR1L LMBR1L OTUD5 OTUD5 SFRP2 SFRP2 TBX2 TBX2 ZNF281 ZNF281 CORO1C CORO1C MEF2C MEF2C PHOX2B PHOX2B REST REST ELL3 ELL3 WNT3 WNT3 ZFP36 ZFP36 ZIC3 ZIC3 PHF5A PHF5A SEMA4D SEMA4D ENSTTRP00000003143 ENSTTRP00000003143 ENSTTRP00000003065 ENSTTRP00000003065 TBX3 TBX3 ESR1 ESR1 MYOCD MYOCD FOXA1 FOXA1 HMGA2 HMGA2 SP7 SP7 FRZB FRZB EDNRA EDNRA ALDH1A2 ALDH1A2 MSI2 MSI2 METTL5 METTL5 GDNF GDNF PHACTR4 PHACTR4 EPOP EPOP SEMA6B SEMA6B HES1 HES1 RET RET LIF LIF FAM172A FAM172A SEMA4A SEMA4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDNRBEndothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (530 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (208 aa)
SEMA3GSemaphorin 3G. (765 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
ANXA6Annexin. (722 aa)
ENSTTRP00000000710annotation not available (306 aa)
SH2B3SH2B adapter protein 3 isoform X2. (558 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X2. (751 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
TBXTBrachyury protein isoform X1. (435 aa)
HTR2BLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B. (479 aa)
SEMA4Bsemaphorin-4B isoform X1; Belongs to the semaphorin family. (827 aa)
SETD2Histone-lysine N-methyltransferase SETD2. (2054 aa)
SEMA6Dsemaphorin-6D; Belongs to the semaphorin family. (1073 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
NELFBNegative elongation factor B. (580 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (774 aa)
GPM6ANeuronal membrane glycoprotein M6-a. (278 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (716 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ALX1ALX homeobox protein 1. (326 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
JARID2Protein Jumonji. (1235 aa)
SIX1Homeobox protein SIX1. (284 aa)
HOXD4Homeobox protein Hox-D4. (254 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
GATA6Transcription factor GATA-6. (592 aa)
PEF1Peflin isoform X1. (290 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1294 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1611 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (773 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (824 aa)
CYP26C1Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (398 aa)
HOXB4Homeobox B4. (251 aa)
MSX1Homeobox protein MSX-1. (303 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8. (574 aa)
RADILRas-associating and dilute domain-containing protein-like. (1072 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
SEMA5BSemaphorin 5B. (1138 aa)
TAL1T-cell acute lymphocytic leukemia protein 1. (330 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ECE2Endothelin-converting enzyme 2 isoform X1. (877 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
LAMA5Laminin subunit alpha-5-like. (3506 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
LOC101333926RE1-silencing transcription factor-like. (974 aa)
FOLR1Folate receptor gamma. (251 aa)
ERBB4Receptor protein-tyrosine kinase. (1299 aa)
WNT10AWnt family member 10A. (417 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (786 aa)
MLLT3Protein AF-9. (567 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
ENSTTRP00000009296annotation not available (181 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
NRTNNeurturin. (197 aa)
SHC4SHC-transforming protein 4. (630 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
HESX1Homeobox expressed in ES cells 1 isoform X1. (132 aa)
XRCC5X-ray repair cross-complementing protein 5 isoform X1. (733 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X2. (1274 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (471 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (772 aa)
ENSTTRP00000007731annotation not available (287 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group). (663 aa)
GSCHomeobox protein goosecoid. (256 aa)
SEMA4Csemaphorin-4C. (833 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (747 aa)
SEMA3FSemaphorin 3F. (784 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
GBX2Homeobox protein GBX-2 isoform X1. (348 aa)
PUM1Pumilio homolog 1 isoform X5. (1223 aa)
CDH2Cadherin-2 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
SRFSerum response factor isoform X2. (509 aa)
SEMA6CSemaphorin 6C. (966 aa)
MTF2Metal-response element-binding transcription factor 2. (596 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (587 aa)
HOXA7Homeobox protein Hox-A7. (235 aa)
PHF19PHD finger protein 19. (517 aa)
KLHL12Kelch-like protein 12 isoform X4. (567 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CTNNB1Catenin beta-1. (781 aa)
EDN1Endothelin-1. (202 aa)
EFNB1Ephrin B1. (346 aa)
SOX8Transcription factor SOX-8. (445 aa)
UFL1E3 UFM1-protein ligase 1 isoform X1. (791 aa)
SOX9Transcription factor SOX-9. (509 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
FOXO4Forkhead box O4. (511 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
SEMA5Asemaphorin-5A. (1073 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1032 aa)
SOX10Transcription factor SOX-10. (468 aa)
LMBR1LProtein LMBR1L isoform X1; Belongs to the LIMR family. (487 aa)
OTUD5OTU domain-containing protein 5 isoform X4. (568 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
TBX2T-box transcription factor TBX2. (703 aa)
ZNF281Zinc finger protein 281. (707 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (464 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (234 aa)
RESTRE1-silencing transcription factor. (656 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X1. (395 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ZFP36ZFP36 ring finger protein. (322 aa)
ZIC3Zinc finger protein ZIC 3 isoform X1. (462 aa)
PHF5APHD finger-like domain-containing protein 5A. (110 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
ENSTTRP00000003143annotation not available (114 aa)
ENSTTRP00000003065annotation not available (386 aa)
TBX3T-box transcription factor TBX3. (742 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
MYOCDMyocardin isoform X1. (968 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (442 aa)
HMGA2High mobility group protein HMGI-C. (83 aa)
SP7Krueppel-like factor 13. (329 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ALDH1A2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
MSI2RNA-binding protein Musashi homolog 2 isoform X1. (238 aa)
METTL5Methyltransferase-like protein 5 isoform X2. (205 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X2. (211 aa)
PHACTR4Phosphatase and actin regulator. (718 aa)
EPOPUncharacterized protein C17orf96 homolog. (379 aa)
SEMA6Bsemaphorin-6B-like. (677 aa)
HES1Transcription factor HES-1. (280 aa)
RETRet proto-oncogene. (1113 aa)
LIFLeukemia inhibitory factor. (202 aa)
FAM172AProtein FAM172A isoform X1. (416 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
Server load: low (28%) [HD]