(28 nodes) Homeostasis of number of cells within a tissue network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VPS54	Vacuolar protein sorting-associated protein 54 isoform X1. (942 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
	LRRC45	Leucine rich repeat containing 45. (670 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP isoform X2. (497 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (361 aa)
	CD7	T-cell antigen CD7. (206 aa)
	KMT2A	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3820 aa)
	GATA1	Erythroid transcription factor. (383 aa)
	BCL2	Apoptosis regulator Bcl-2 isoform X1. (233 aa)
	CORO1A	Coronin 1A. (461 aa)
	SOX9	Transcription factor SOX-9. (509 aa)
	ILDR2	Immunoglobulin-like domain-containing receptor 2. (636 aa)
	KLHL10	LOW QUALITY PROTEIN: kelch-like protein 10. (608 aa)
	F2R	Proteinase-activated receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (329 aa)
	VHL	LOW QUALITY PROTEIN: von Hippel-Lindau disease tumor suppressor. (206 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	ADD1	Adducin 1. (766 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
	ENSTTRP00000015206	annotation not available (554 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (551 aa)
	PRDM14	PR domain zinc finger protein 14. (570 aa)
	KRAS	GTPase KRas. (189 aa)
	IL20RB	Interleukin-20 receptor subunit beta isoform X1. (310 aa)
	FH	Fumarate hydratase, mitochondrial. (504 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	BCL2	ENSTTRP00000010770	ENSTTRP00000004766	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Apoptosis regulator Bcl-2 isoform X1.	0.942
AKT3	KRAS	ENSTTRP00000010770	ENSTTRP00000011954	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	GTPase KRas.	0.508
BCL2	AKT3	ENSTTRP00000004766	ENSTTRP00000010770	Apoptosis regulator Bcl-2 isoform X1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.942
BCL2	IL7	ENSTTRP00000004766	ENSTTRP00000000864	Apoptosis regulator Bcl-2 isoform X1.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.541
BCL2	KRAS	ENSTTRP00000004766	ENSTTRP00000011954	Apoptosis regulator Bcl-2 isoform X1.	GTPase KRas.	0.733
BCL2	NOTCH1	ENSTTRP00000004766	ENSTTRP00000007173	Apoptosis regulator Bcl-2 isoform X1.	Neurogenic locus notch homolog protein 1.	0.551
BCL2	XIAP	ENSTTRP00000004766	ENSTTRP00000001865	Apoptosis regulator Bcl-2 isoform X1.	E3 ubiquitin-protein ligase XIAP isoform X2.	0.814
CD7	IL7	ENSTTRP00000002987	ENSTTRP00000000864	T-cell antigen CD7.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.428
CORO1A	SASH3	ENSTTRP00000005229	ENSTTRP00000002007	Coronin 1A.	SAM and SH3 domain-containing protein 3.	0.449
ENSTTRP00000015206	IL7	ENSTTRP00000015206	ENSTTRP00000000864	annotation not available	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.561
GATA1	KMT2A	ENSTTRP00000004388	ENSTTRP00000004041	Erythroid transcription factor.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	0.581
IL20RB	IL7	ENSTTRP00000011258	ENSTTRP00000000864	Interleukin-20 receptor subunit beta isoform X1.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.766
IL7	BCL2	ENSTTRP00000000864	ENSTTRP00000004766	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	Apoptosis regulator Bcl-2 isoform X1.	0.541
IL7	CD7	ENSTTRP00000000864	ENSTTRP00000002987	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	T-cell antigen CD7.	0.428
IL7	ENSTTRP00000015206	ENSTTRP00000000864	ENSTTRP00000015206	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	annotation not available	0.561
IL7	IL20RB	ENSTTRP00000000864	ENSTTRP00000011258	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	Interleukin-20 receptor subunit beta isoform X1.	0.766
KMT2A	GATA1	ENSTTRP00000004041	ENSTTRP00000004388	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	Erythroid transcription factor.	0.581
KRAS	AKT3	ENSTTRP00000011954	ENSTTRP00000010770	GTPase KRas.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.508
KRAS	BCL2	ENSTTRP00000011954	ENSTTRP00000004766	GTPase KRas.	Apoptosis regulator Bcl-2 isoform X1.	0.733
KRAS	NOTCH1	ENSTTRP00000011954	ENSTTRP00000007173	GTPase KRas.	Neurogenic locus notch homolog protein 1.	0.566