STRINGSTRING
ENSTTRP00000009296 ENSTTRP00000009296 NOTCH2 NOTCH2 FZD7 FZD7 FGF9 FGF9 ENSTTRP00000000927 ENSTTRP00000000927 CCL26 CCL26 CCL24 CCL24 KDM5B KDM5B SFRP1 SFRP1 IQGAP3 IQGAP3 PDGFB PDGFB SIRT6 SIRT6 LRG1 LRG1 MYDGF MYDGF THBS4 THBS4 PGF PGF C5AR2 C5AR2 TCF7L2 TCF7L2 EPGN EPGN EMC10 EMC10 KDR KDR BMP2 BMP2 MST1 MST1 PDX1 PDX1 NR4A1 NR4A1 PIK3CD PIK3CD NODAL NODAL PROX1 PROX1 ENSTTRP00000003306 ENSTTRP00000003306 TNFAIP3 TNFAIP3 AR AR VIP VIP FGFR1 FGFR1 RTN4 RTN4 EGF EGF FGF1 FGF1 ACVRL1 ACVRL1 BMPR2 BMPR2 VEGFC VEGFC WNT5A WNT5A SOX9 SOX9 BMP5 BMP5 CCL5 CCL5 FLT4 FLT4 CTNNB1 CTNNB1 WDR48 WDR48 PDCL3 PDCL3 ENSTTRP00000006381 ENSTTRP00000006381 HYAL1 HYAL1 TGFA TGFA RUNX2 RUNX2 STAT5A STAT5A STAT3 STAT3 HMOX1 HMOX1 B4GALT1 B4GALT1 ODAM ODAM OSR2 OSR2 VHL VHL NOTCH1 NOTCH1 EGFL7 EGFL7 DLX5 DLX5 PPP1R16B PPP1R16B F3 F3 BMPR1A BMPR1A PRKCA PRKCA ENSTTRP00000007731 ENSTTRP00000007731 ERBB2 ERBB2 PDPK1 PDPK1 AGAP2 AGAP2 PKHD1 PKHD1 SMO SMO MED1 MED1 CAV2 CAV2 TGM1 TGM1 CDH13 CDH13 PTN PTN FGF7 FGF7 VEGFA VEGFA BMP4 BMP4 AGGF1 AGGF1 AGTR1 AGTR1 SP1 SP1 OSR1 OSR1 PTPRN PTPRN HSF4 HSF4 VEGFB VEGFB BAD BAD WNT2 WNT2 FGF10 FGF10 GRN GRN ECM1 ECM1 HRAS HRAS AKT3 AKT3 HPN HPN JUN JUN CLDN1 CLDN1 LOC101333923 LOC101333923 TP63 TP63 YAP1 YAP1 PLXNB3 PLXNB3 STXBP4 STXBP4 NKX2-6 NKX2-6 EYA1 EYA1 MTA3 MTA3 EGR3 EGR3 PRKD2 PRKD2 NOD2 NOD2 GDF2 GDF2 ITGB3 ITGB3 TGFBR1 TGFBR1 SHH SHH VASH2 VASH2 SAAL1 SAAL1 ST8SIA1 ST8SIA1 PRKD1 PRKD1 CCL11 CCL11 ESRP2 ESRP2 PAX2 PAX2 APLNR APLNR NF1 NF1 SRSF6 SRSF6 NRAS NRAS PROK1 PROK1 BMP6 BMP6 CDH3 CDH3 HTR2B HTR2B HMX2 HMX2 SIRT1 SIRT1 MYC MYC ENSTTRP00000015784 ENSTTRP00000015784 JCAD JCAD ITGA4 ITGA4 ZNF703 ZNF703 IGF1 IGF1 EGFR EGFR CCND1 CCND1 RREB1 RREB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSTTRP00000009296annotation not available (181 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (544 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSTTRP00000000927annotation not available (104 aa)
CCL26C-C motif chemokine 26. (94 aa)
CCL24C-C motif chemokine 24. (119 aa)
KDM5BLysine-specific demethylase 5B isoform X1. (1631 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3 isoform X1. (1636 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X5. (245 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (347 aa)
MYDGFMyeloid derived growth factor. (173 aa)
THBS4Thrombospondin-4. (948 aa)
PGFPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (215 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2 isoform X1. (304 aa)
TCF7L2Transcription factor 7-like 2 isoform X5. (639 aa)
EPGNEpigen. (133 aa)
EMC10ER membrane protein complex subunit 10. (268 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1307 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
MST1Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (709 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (632 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
NODALNodal homolog. (348 aa)
PROX1Prospero homeobox protein 1. (744 aa)
ENSTTRP00000003306annotation not available (682 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
ARAndrogen receptor. (886 aa)
VIPVIP peptides. (170 aa)
FGFR1Fibroblast growth factor receptor 1. (822 aa)
RTN4Reticulon. (1189 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ACVRL1Activin A receptor like type 1. (497 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
VEGFCVascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (420 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
SOX9Transcription factor SOX-9. (509 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
CCL5C-C motif chemokine. (91 aa)
FLT4Vascular endothelial growth factor receptor 3. (1363 aa)
CTNNB1Catenin beta-1. (781 aa)
WDR48WD repeat-containing protein 48 isoform X2. (677 aa)
PDCL3Phosducin-like protein 3 isoform X2. (240 aa)
ENSTTRP00000006381annotation not available (382 aa)
HYAL1Hyaluronidase. (432 aa)
TGFAProtransforming growth factor alpha isoform X1. (224 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (587 aa)
STAT5ASignal transducer and activator of transcription 5A. (794 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
ODAMLOW QUALITY PROTEIN: odontogenic ameloblast-associated protein. (279 aa)
OSR2Protein odd-skipped-related 2. (312 aa)
VHLLOW QUALITY PROTEIN: von Hippel-Lindau disease tumor suppressor. (206 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
EGFL7Epidermal growth factor-like protein 7 isoform X1. (265 aa)
DLX5Homeobox protein DLX-5. (289 aa)
PPP1R16BProtein phosphatase 1 regulatory inhibitor subunit 16B. (568 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (291 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
ENSTTRP00000007731annotation not available (287 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1228 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1190 aa)
PKHD1Fibrocystin. (4066 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K. (824 aa)
CDH13Cadherin-13 isoform X2. (608 aa)
PTNPleiotrophin isoform X1. (249 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
VEGFAVascular endothelial growth factor A. (402 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1 isoform X1. (714 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
SP1Transcription factor Sp1. (784 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (980 aa)
HSF4Heat shock factor protein 4. (438 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (172 aa)
BADBCL2 associated agonist of cell death. (150 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGF10Fibroblast growth factor 10. (142 aa)
GRNGranulins. (588 aa)
ECM1Extracellular matrix protein 1-like. (557 aa)
HRASGTPase HRas isoform X1. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
HPNHepsin. (526 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (321 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC101333923Prorelaxin isoform X1. (183 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
YAP1Transcriptional coactivator YAP1 isoform X4. (488 aa)
PLXNB3plexin-B3. (1891 aa)
STXBP4Syntaxin-binding protein 4. (553 aa)
NKX2-6Homeobox protein Nkx-2.6. (299 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
MTA3Metastasis-associated protein MTA3 isoform X2. (584 aa)
EGR3Early growth response 3. (387 aa)
PRKD2Serine/threonine-protein kinase D2. (837 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1038 aa)
GDF2Growth/differentiation factor 2. (431 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
VASH2Vasohibin 2. (311 aa)
SAAL1Protein SAAL1 isoform X2. (440 aa)
ST8SIA1alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family. (355 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (876 aa)
CCL11C-C motif chemokine. (97 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
PAX2LOW QUALITY PROTEIN: paired box protein Pax-2. (419 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NF1Neurofibromin. (2814 aa)
SRSF6LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like. (259 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
PROK1Prokineticin-1. (105 aa)
BMP6Bone morphogenetic protein 6. (304 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (830 aa)
HTR2BLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B. (479 aa)
HMX2H6 family homeobox 2. (183 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (616 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ENSTTRP00000015784annotation not available (149 aa)
JCADJunctional protein associated with coronary artery disease. (1265 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1037 aa)
ZNF703Zinc finger protein 703. (585 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RREB1Ras-responsive element-binding protein 1 isoform X1. (1737 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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