STRINGSTRING
PTPRC PTPRC IL15 IL15 HGF HGF CD40 CD40 EPHA4 EPHA4 LRP8 LRP8 PDGFB PDGFB MTOR MTOR LIF LIF OSM OSM HES1 HES1 THBS4 THBS4 BTC BTC EPGN EPGN EREG EREG PTK2B PTK2B IL11 IL11 TREM2 TREM2 IL5 IL5 HTR2A HTR2A LTK LTK GRM5 GRM5 ABI1 ABI1 SEMA4D SEMA4D NEURL1 NEURL1 SYK SYK SH2D1B SH2D1B AGT AGT UNC119 UNC119 PIBF1 PIBF1 ITGA5 ITGA5 GATA1 GATA1 EGF EGF ADRA1A ADRA1A PECAM1 PECAM1 LRRK1 LRRK1 FBXW9 FBXW9 HBEGF HBEGF SRC SRC IL34 IL34 IL12B IL12B SRCIN1 SRCIN1 IFNG IFNG FBXW7 FBXW7 ENSTTRP00000006381 ENSTTRP00000006381 PLCG2 PLCG2 CASS4 CASS4 TGFA TGFA ENSTTRP00000006594 ENSTTRP00000006594 CSF2 CSF2 ADRA2A ADRA2A ENSTTRP00000006769 ENSTTRP00000006769 GHRL GHRL ENSTTRP00000007761 ENSTTRP00000007761 ALK ALK CSF1R CSF1R FGF7 FGF7 VEGFA VEGFA GAS6 GAS6 PTPN11 PTPN11 CD44 CD44 PRNP PRNP IL12A IL12A ANGPT4 ANGPT4 DVL2 DVL2 EFNA5 EFNA5 NRP1 NRP1 ERBB4 ERBB4 VTN VTN AFAP1L2 AFAP1L2 FGF10 FGF10 CRLF1 CRLF1 RELN RELN ALKAL2 ALKAL2 ISL1 ISL1 GFRA1 GFRA1 FGFR1-2 FGFR1-2 EPO EPO DGKQ DGKQ HCLS1 HCLS1 TAL1 TAL1 RICTOR RICTOR AREG AREG NOX4 NOX4 NRG1 NRG1 ARL2BP ARL2BP CD74 CD74 CD81 CD81 ARHGEF2 ARHGEF2 NOD2 NOD2 PARP9 PARP9 ITGB3 ITGB3 PAK2 PAK2 NEDD9 NEDD9 ENPP2 ENPP2 IL6R IL6R LRP4 LRP4 RIPK2 RIPK2 PTPN1 PTPN1 CD80 CD80 TNFRSF1A TNFRSF1A IL21 IL21 FYN FYN BANK1 BANK1 ERCC6 ERCC6 ALKAL1 ALKAL1 FGF8 FGF8 ABL1 ABL1 KIT KIT IGF2 IGF2 CTF1 CTF1 NCF1 NCF1 DOK7 DOK7 HAX1 HAX1 BMP6 BMP6 IL31RA IL31RA IL6ST IL6ST PLPP3 PLPP3 EFNA1 EFNA1 ERBB3 ERBB3 LYN LYN CSF3 CSF3 IGF1 IGF1 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X2. (1274 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (727 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (979 aa)
LRP8Low-density lipoprotein receptor-related protein 8. (945 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
LIFLeukemia inhibitory factor. (202 aa)
OSMOncostatin M. (233 aa)
HES1Transcription factor HES-1. (280 aa)
THBS4Thrombospondin-4. (948 aa)
BTCProbetacellulin isoform X2. (178 aa)
EPGNEpigen. (133 aa)
EREGProepiregulin isoform X2. (169 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (941 aa)
IL11Interleukin 11. (199 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (168 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (829 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1199 aa)
ABI1Abl interactor 1 isoform X13. (492 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1. (574 aa)
SYKTyrosine-protein kinase. (629 aa)
SH2D1BSH2 domain-containing protein 1B isoform X1. (132 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
UNC119Protein unc-119 homolog A. (166 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X4. (756 aa)
ITGA5Integrin subunit alpha 5. (1053 aa)
GATA1Erythroid transcription factor. (383 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
ADRA1Aalpha-1A adrenergic receptor. (423 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X2. (420 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2028 aa)
FBXW9F-box and WD repeat domain containing 9. (487 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
IL34Interleukin 34. (241 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
SRCIN1SRC kinase signaling inhibitor 1-like. (1133 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
ENSTTRP00000006381annotation not available (382 aa)
PLCG2Phosphoinositide phospholipase C. (1264 aa)
CASS4Cas scaffolding protein family member 4 isoform X1. (600 aa)
TGFAProtransforming growth factor alpha isoform X1. (224 aa)
ENSTTRP00000006594annotation not available (143 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
ADRA2Aalpha-2A adrenergic receptor. (448 aa)
ENSTTRP00000006769annotation not available (133 aa)
GHRLAppetite-regulating hormone. (117 aa)
ENSTTRP00000007761annotation not available (312 aa)
ALKALK tyrosine kinase receptor-like. (1614 aa)
CSF1RLOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor-like. (959 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
VEGFAVascular endothelial growth factor A. (402 aa)
GAS6Growth arrest specific 6. (719 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CD44CD44 antigen isoform X1. (742 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ANGPT4Angiopoietin-4 isoform X2. (498 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X9. (736 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ERBB4Receptor protein-tyrosine kinase. (1299 aa)
VTNVitronectin. (480 aa)
AFAP1L2Actin filament-associated protein 1-like 2 isoform X3. (767 aa)
FGF10Fibroblast growth factor 10. (142 aa)
CRLF1Cytokine receptor like factor 1. (382 aa)
RELNLOW QUALITY PROTEIN: reelin. (3457 aa)
ALKAL2Protein FAM150B. (154 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
GFRA1GDNF family receptor alpha; Belongs to the GDNFR family. (463 aa)
FGFR1-2Fibroblast growth factor receptor 1. (692 aa)
EPOErythropoietin. (192 aa)
DGKQDiacylglycerol kinase. (949 aa)
HCLS1Hematopoietic lineage cell-specific protein. (484 aa)
TAL1T-cell acute lymphocytic leukemia protein 1. (330 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X2. (1636 aa)
AREGAmphiregulin isoform X2. (253 aa)
NOX4NADPH oxidase 4. (577 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X2. (646 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein. (162 aa)
CD74CD74 molecule. (294 aa)
CD81CD81 molecule. (214 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (987 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1038 aa)
PARP9Poly [ADP-ribose] polymerase 9. (845 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
NEDD9Enhancer of filamentation 1. (829 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X4. (914 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X2. (466 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1924 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (538 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (428 aa)
CD80T-lymphocyte activation antigen CD80 isoform X2. (288 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (439 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (160 aa)
FYNTyrosine-protein kinase. (537 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X4. (743 aa)
ERCC6DNA excision repair protein ERCC-6 isoform X2. (1483 aa)
ALKAL1Protein FAM150A. (121 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
IGF2Insulin-like growth factor II. (184 aa)
CTF1Cardiotrophin-1. (202 aa)
NCF1Neutrophil cytosol factor 1. (340 aa)
DOK7Protein Dok-7 isoform X1. (586 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (277 aa)
BMP6Bone morphogenetic protein 6. (304 aa)
IL31RALOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha. (752 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
PLPP3Phospholipid phosphatase 3 isoform X3. (312 aa)
EFNA1ephrin-A1 isoform X2; Belongs to the ephrin family. (205 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3 isoform X1. (1336 aa)
LYNTyrosine-protein kinase. (491 aa)
CSF3Colony stimulating factor 3. (207 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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