(30 nodes) Smooth muscle cell differentiation network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	RAMP2	Receptor activity modifying protein 2. (176 aa)
	TMEM204	Transmembrane protein 204. (225 aa)
	GATA6	Transcription factor GATA-6. (592 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	ENSTTRP00000014726	annotation not available (263 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
	ENG	Endoglin. (655 aa)
	MYOCD	Myocardin isoform X1. (968 aa)
	TBX3	T-box transcription factor TBX3. (742 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X1. (472 aa)
	TBX2	T-box transcription factor TBX2. (703 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
	NPNT	Nephronectin isoform X2. (560 aa)
	SOX9	Transcription factor SOX-9. (509 aa)
	FOXF1	Forkhead box F1. (372 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	MRTFB	MKL/myocardin-like protein 2 isoform X3. (969 aa)
	SRF	Serum response factor isoform X2. (509 aa)
	EDNRA	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	HES1	Transcription factor HES-1. (280 aa)
	EDNRB	Endothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (530 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1. (193 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	NFATC4	Nuclear factor of activated T cells 4. (746 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	FGF10	Fibroblast growth factor 10. (142 aa)
	MRTFA	Phosphatase and actin regulator. (925 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	CTNNB1	ENSTTRP00000008787	ENSTTRP00000005764	Bone morphogenetic protein 4.	Catenin beta-1.	0.688
BMP4	FGF10	ENSTTRP00000008787	ENSTTRP00000009805	Bone morphogenetic protein 4.	Fibroblast growth factor 10.	0.819
BMP4	FOXF1	ENSTTRP00000008787	ENSTTRP00000005561	Bone morphogenetic protein 4.	Forkhead box F1.	0.555
BMP4	GATA6	ENSTTRP00000008787	ENSTTRP00000012663	Bone morphogenetic protein 4.	Transcription factor GATA-6.	0.662
BMP4	MEF2C	ENSTTRP00000008787	ENSTTRP00000003719	Bone morphogenetic protein 4.	Myocyte-specific enhancer factor 2C isoform X1.	0.418
BMP4	NOTCH1	ENSTTRP00000008787	ENSTTRP00000007173	Bone morphogenetic protein 4.	Neurogenic locus notch homolog protein 1.	0.417
BMP4	SOX9	ENSTTRP00000008787	ENSTTRP00000005370	Bone morphogenetic protein 4.	Transcription factor SOX-9.	0.664
BMP4	TBX3	ENSTTRP00000008787	ENSTTRP00000003015	Bone morphogenetic protein 4.	T-box transcription factor TBX3.	0.522
COMP	SOX9	ENSTTRP00000009970	ENSTTRP00000005370	Cartilage oligomeric matrix protein.	Transcription factor SOX-9.	0.563
CTNNB1	BMP4	ENSTTRP00000005764	ENSTTRP00000008787	Catenin beta-1.	Bone morphogenetic protein 4.	0.688
CTNNB1	ENSTTRP00000009296	ENSTTRP00000005764	ENSTTRP00000009296	Catenin beta-1.	annotation not available	0.436
CTNNB1	FGF10	ENSTTRP00000005764	ENSTTRP00000009805	Catenin beta-1.	Fibroblast growth factor 10.	0.576
CTNNB1	GATA6	ENSTTRP00000005764	ENSTTRP00000012663	Catenin beta-1.	Transcription factor GATA-6.	0.406
CTNNB1	MEF2C	ENSTTRP00000005764	ENSTTRP00000003719	Catenin beta-1.	Myocyte-specific enhancer factor 2C isoform X1.	0.822
CTNNB1	NOTCH1	ENSTTRP00000005764	ENSTTRP00000007173	Catenin beta-1.	Neurogenic locus notch homolog protein 1.	0.757
CTNNB1	SOX9	ENSTTRP00000005764	ENSTTRP00000005370	Catenin beta-1.	Transcription factor SOX-9.	0.920
EDNRA	EDNRB	ENSTTRP00000002303	ENSTTRP00000001342	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family.	0.917
EDNRB	EDNRA	ENSTTRP00000001342	ENSTTRP00000002303	Endothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.917
ENSTTRP00000009296	CTNNB1	ENSTTRP00000009296	ENSTTRP00000005764	annotation not available	Catenin beta-1.	0.436
FGF10	BMP4	ENSTTRP00000009805	ENSTTRP00000008787	Fibroblast growth factor 10.	Bone morphogenetic protein 4.	0.819