(50 nodes) SMAD protein signal transduction network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	GDF3	Growth/differentiation factor 3. (364 aa)
	HEXA	Beta-hexosaminidase. (529 aa)
	BMP2	Bone morphogenetic protein 2. (388 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SMAD3	Mothers against decapentaplegic homolog 3. (291 aa)
	NODAL	Nodal homolog. (348 aa)
	BMP3	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
	NUP93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (817 aa)
	GDF15	Growth differentiation factor 15. (308 aa)
	SMAD7	Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
	BMP5	Bone morphogenetic protein 5 isoform X2. (454 aa)
	CITED1	Cbp/p300-interacting transactivator 1 isoform X1. (191 aa)
	AFP	Alpha-fetoprotein. (610 aa)
	TF	Serotransferrin; Belongs to the transferrin family. (700 aa)
	SMAD9	Mothers against decapentaplegic homolog. (466 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	HNF1A	HNF1 homeobox A. (632 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	GDF11	Growth differentiation factor 11. (313 aa)
	SKI	Ski oncogene. (633 aa)
	SMAD6	SMAD family member 6. (492 aa)
	BTBD11	BTB domain containing 11. (1108 aa)
	ATOH8	Protein atonal homolog 8. (411 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (321 aa)
	LOC101325454	Bone morphogenetic protein 8B. (241 aa)
	GDF1	Embryonic growth/differentiation factor 1. (370 aa)
	SMAD4	Mothers against decapentaplegic homolog. (407 aa)
	GDF6	Growth/differentiation factor 6. (458 aa)
	ENSTTRP00000011729	annotation not available (367 aa)
	HNF4A	Hepatocyte nuclear factor 4-alpha isoform X1. (448 aa)
	INHBC	Inhibin beta C chain. (247 aa)
	INHBE	Inhibin subunit beta E. (351 aa)
	GDF2	Growth/differentiation factor 2. (431 aa)
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
	BMP10	Bone morphogenetic protein 10. (423 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
	INHBB	Inhibin beta B chain. (407 aa)
	LOC101327238	Left-right determination factor. (201 aa)
	SLC33A1	Acetyl-coenzyme A transporter 1. (550 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (278 aa)
	HIPK2	Homeodomain-interacting protein kinase 2. (1185 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
	BMP7	Bone morphogenetic protein 7 isoform X2. (431 aa)
	BMP6	Bone morphogenetic protein 6. (304 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	TBXT	Brachyury protein isoform X1. (435 aa)
	JADE2	Jade family PHD finger 2. (828 aa)
	GDF5	Growth/differentiation factor 5. (489 aa)
	SUB1	Activated RNA polymerase II transcriptional coactivator p15. (103 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFP	BMP4	ENSTTRP00000006228	ENSTTRP00000008787	Alpha-fetoprotein.	Bone morphogenetic protein 4.	0.525
AFP	HNF4A	ENSTTRP00000006228	ENSTTRP00000012345	Alpha-fetoprotein.	Hepatocyte nuclear factor 4-alpha isoform X1.	0.782
AFP	TF	ENSTTRP00000006228	ENSTTRP00000007358	Alpha-fetoprotein.	Serotransferrin; Belongs to the transferrin family.	0.565
BMP10	BMP2	ENSTTRP00000012877	ENSTTRP00000002383	Bone morphogenetic protein 10.	Bone morphogenetic protein 2.	0.417
BMP10	BMP4	ENSTTRP00000012877	ENSTTRP00000008787	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.630
BMP10	BMP5	ENSTTRP00000012877	ENSTTRP00000005374	Bone morphogenetic protein 10.	Bone morphogenetic protein 5 isoform X2.	0.653
BMP10	BMP7	ENSTTRP00000012877	ENSTTRP00000014836	Bone morphogenetic protein 10.	Bone morphogenetic protein 7 isoform X2.	0.423
BMP10	GDF15	ENSTTRP00000012877	ENSTTRP00000004094	Bone morphogenetic protein 10.	Growth differentiation factor 15.	0.414
BMP10	GDF2	ENSTTRP00000012877	ENSTTRP00000012735	Bone morphogenetic protein 10.	Growth/differentiation factor 2.	0.946
BMP10	GDF5	ENSTTRP00000012877	ENSTTRP00000016136	Bone morphogenetic protein 10.	Growth/differentiation factor 5.	0.406
BMP10	SMAD2	ENSTTRP00000012877	ENSTTRP00000002462	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.414
BMP10	SMAD3	ENSTTRP00000012877	ENSTTRP00000002846	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog 3.	0.634
BMP10	SMAD4	ENSTTRP00000012877	ENSTTRP00000011160	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.530
BMP10	SMAD5	ENSTTRP00000012877	ENSTTRP00000015426	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.590
BMP2	BMP10	ENSTTRP00000002383	ENSTTRP00000012877	Bone morphogenetic protein 2.	Bone morphogenetic protein 10.	0.417
BMP2	BMP4	ENSTTRP00000002383	ENSTTRP00000008787	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.899
BMP2	BMP5	ENSTTRP00000002383	ENSTTRP00000005374	Bone morphogenetic protein 2.	Bone morphogenetic protein 5 isoform X2.	0.616
BMP2	BMP6	ENSTTRP00000002383	ENSTTRP00000015103	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.938
BMP2	BMP7	ENSTTRP00000002383	ENSTTRP00000014836	Bone morphogenetic protein 2.	Bone morphogenetic protein 7 isoform X2.	0.719
BMP2	GDF5	ENSTTRP00000002383	ENSTTRP00000016136	Bone morphogenetic protein 2.	Growth/differentiation factor 5.	0.543