(51 nodes) Regulation of cartilage development network (Tursiops truncatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	FGF18	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (207 aa)
	WISP1	WNT1-inducible-signaling pathway protein 1. (259 aa)
	RFLNA	Refilin A. (201 aa)
	GLG1	Golgi apparatus protein 1. (1196 aa)
	SIX2	Homeobox protein SIX2. (168 aa)
	CYR61	Protein CYR61. (382 aa)
	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1 isoform X1. (489 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
	SHOX2	LOW QUALITY PROTEIN: short stature homeobox protein 2. (282 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1301 aa)
	FRZB	Secreted frizzled-related protein 3. (325 aa)
	BMP2	Bone morphogenetic protein 2. (388 aa)
	RARG	Retinoic acid receptor beta. (453 aa)
	SMAD3	Mothers against decapentaplegic homolog 3. (291 aa)
	RFLNB	Filamin-interacting protein FAM101B isoform X1. (146 aa)
	SOX6	Transcription factor SOX-6. (828 aa)
	CHADL	Chondroadherin-like protein isoform X1. (745 aa)
	HOXA11	Homeobox protein Hox-A11. (311 aa)
	ENSTTRP00000003397	annotation not available (173 aa)
	GLI3	Transcriptional activator GLI3. (1580 aa)
	PTHLH	Parathyroid hormone-related protein isoform X1. (252 aa)
	ZNF219	Zinc finger protein 219 isoform X2. (716 aa)
	SMAD7	Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
	SOX9	Transcription factor SOX-9. (509 aa)
	SCIN	Adseverin isoform X1. (713 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	SCX	Scleraxis bHLH transcription factor. (203 aa)
	KAT2A	Histone acetyltransferase KAT2A. (835 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (587 aa)
	CTSK	Cathepsin K isoform X1; Belongs to the peptidase C1 family. (328 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	AXIN2	Axin-2-like. (839 aa)
	IHH	Indian hedgehog protein. (409 aa)
	RARB	Retinoic acid receptor beta. (522 aa)
	ADAMTS12	A disintegrin and metalloproteinase with thrombospondin motifs 12. (1598 aa)
	LOXL2	Lysyl oxidase homolog 2. (771 aa)
	GDF6	Growth/differentiation factor 6. (458 aa)
	PKDCC	Extracellular tyrosine-protein kinase PKDCC. (280 aa)
	BMP1	Metalloendopeptidase. (929 aa)
	TGFB1	Transforming growth factor beta 1. (338 aa)
	SOX5	Transcription factor SOX-5 isoform X2. (742 aa)
	GDF2	Growth/differentiation factor 2. (431 aa)
	BMP10	Bone morphogenetic protein 10. (423 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
	LNPK	Protein lunapark isoform X1. (429 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	RARA	Retinoic acid receptor alpha-like. (618 aa)
	GDF5	Growth/differentiation factor 5. (489 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSTTRP00000008850	ENSTTRP00000008787	Axin-2-like.	Bone morphogenetic protein 4.	0.554
AXIN2	CTNNB1	ENSTTRP00000008850	ENSTTRP00000005764	Axin-2-like.	Catenin beta-1.	0.993
AXIN2	FRZB	ENSTTRP00000008850	ENSTTRP00000002352	Axin-2-like.	Secreted frizzled-related protein 3.	0.550
AXIN2	RUNX2	ENSTTRP00000008850	ENSTTRP00000006566	Axin-2-like.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.525
AXIN2	SOX9	ENSTTRP00000008850	ENSTTRP00000005370	Axin-2-like.	Transcription factor SOX-9.	0.560
AXIN2	WISP1	ENSTTRP00000008850	ENSTTRP00000000107	Axin-2-like.	WNT1-inducible-signaling pathway protein 1.	0.471
AXIN2	WNT5A	ENSTTRP00000008850	ENSTTRP00000004970	Axin-2-like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.781
BMP1	BMP2	ENSTTRP00000012090	ENSTTRP00000002383	Metalloendopeptidase.	Bone morphogenetic protein 2.	0.475
BMP1	BMP4	ENSTTRP00000012090	ENSTTRP00000008787	Metalloendopeptidase.	Bone morphogenetic protein 4.	0.586
BMP1	LOXL2	ENSTTRP00000012090	ENSTTRP00000011629	Metalloendopeptidase.	Lysyl oxidase homolog 2.	0.505
BMP1	TGFB1	ENSTTRP00000012090	ENSTTRP00000012180	Metalloendopeptidase.	Transforming growth factor beta 1.	0.540
BMP10	BMP2	ENSTTRP00000012877	ENSTTRP00000002383	Bone morphogenetic protein 10.	Bone morphogenetic protein 2.	0.417
BMP10	BMP4	ENSTTRP00000012877	ENSTTRP00000008787	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.630
BMP10	BMPR1B	ENSTTRP00000012877	ENSTTRP00000014265	Bone morphogenetic protein 10.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.615
BMP10	GDF2	ENSTTRP00000012877	ENSTTRP00000012735	Bone morphogenetic protein 10.	Growth/differentiation factor 2.	0.946
BMP10	GDF5	ENSTTRP00000012877	ENSTTRP00000016136	Bone morphogenetic protein 10.	Growth/differentiation factor 5.	0.406
BMP10	SMAD3	ENSTTRP00000012877	ENSTTRP00000002846	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog 3.	0.634
BMP10	TGFBR1	ENSTTRP00000012877	ENSTTRP00000012962	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.665
BMP2	BMP1	ENSTTRP00000002383	ENSTTRP00000012090	Bone morphogenetic protein 2.	Metalloendopeptidase.	0.475
BMP2	BMP10	ENSTTRP00000002383	ENSTTRP00000012877	Bone morphogenetic protein 2.	Bone morphogenetic protein 10.	0.417