25 items (Tursiops truncatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX6	Transcription factor SOX-6. (828 aa)
	BMP2	Bone morphogenetic protein 2. (388 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
	CYR61	Protein CYR61. (382 aa)
	GDF5	Growth/differentiation factor 5. (489 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	BMP10	Bone morphogenetic protein 10. (423 aa)
	GDF2	Growth/differentiation factor 2. (431 aa)
	SOX5	Transcription factor SOX-5 isoform X2. (742 aa)
	BMP1	Metalloendopeptidase. (929 aa)
	PKDCC	Extracellular tyrosine-protein kinase PKDCC. (280 aa)
	GDF6	Growth/differentiation factor 6. (458 aa)
	LOXL2	Lysyl oxidase homolog 2. (771 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	FGF18	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (207 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (587 aa)
	SCX	Scleraxis bHLH transcription factor. (203 aa)
	SOX9	Transcription factor SOX-9. (509 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
	SMAD7	Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
	ZNF219	Zinc finger protein 219 isoform X2. (716 aa)
	GLI3	Transcriptional activator GLI3. (1580 aa)
	HOXA11	Homeobox protein Hox-A11. (311 aa)
	SMAD3	Mothers against decapentaplegic homolog 3. (291 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP1	BMP2	ENSTTRP00000012090	ENSTTRP00000002383	Metalloendopeptidase.	Bone morphogenetic protein 2.	0.475
BMP1	BMP4	ENSTTRP00000012090	ENSTTRP00000008787	Metalloendopeptidase.	Bone morphogenetic protein 4.	0.586
BMP1	LOXL2	ENSTTRP00000012090	ENSTTRP00000011629	Metalloendopeptidase.	Lysyl oxidase homolog 2.	0.505
BMP10	BMP2	ENSTTRP00000012877	ENSTTRP00000002383	Bone morphogenetic protein 10.	Bone morphogenetic protein 2.	0.417
BMP10	BMP4	ENSTTRP00000012877	ENSTTRP00000008787	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.630
BMP10	BMPR1B	ENSTTRP00000012877	ENSTTRP00000014265	Bone morphogenetic protein 10.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.615
BMP10	GDF2	ENSTTRP00000012877	ENSTTRP00000012735	Bone morphogenetic protein 10.	Growth/differentiation factor 2.	0.946
BMP10	GDF5	ENSTTRP00000012877	ENSTTRP00000016136	Bone morphogenetic protein 10.	Growth/differentiation factor 5.	0.406
BMP10	SMAD3	ENSTTRP00000012877	ENSTTRP00000002846	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog 3.	0.634
BMP2	BMP1	ENSTTRP00000002383	ENSTTRP00000012090	Bone morphogenetic protein 2.	Metalloendopeptidase.	0.475
BMP2	BMP10	ENSTTRP00000002383	ENSTTRP00000012877	Bone morphogenetic protein 2.	Bone morphogenetic protein 10.	0.417
BMP2	BMP4	ENSTTRP00000002383	ENSTTRP00000008787	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.899
BMP2	BMPR1B	ENSTTRP00000002383	ENSTTRP00000014265	Bone morphogenetic protein 2.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.991
BMP2	FGF18	ENSTTRP00000002383	ENSTTRP00000007934	Bone morphogenetic protein 2.	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family.	0.682
BMP2	GDF5	ENSTTRP00000002383	ENSTTRP00000016136	Bone morphogenetic protein 2.	Growth/differentiation factor 5.	0.543
BMP2	GDF6	ENSTTRP00000002383	ENSTTRP00000011723	Bone morphogenetic protein 2.	Growth/differentiation factor 6.	0.435
BMP2	RUNX2	ENSTTRP00000002383	ENSTTRP00000006566	Bone morphogenetic protein 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.857
BMP2	SMAD1	ENSTTRP00000002383	ENSTTRP00000007646	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.837
BMP2	SMAD3	ENSTTRP00000002383	ENSTTRP00000002846	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog 3.	0.663
BMP2	SMAD7	ENSTTRP00000002383	ENSTTRP00000004100	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog 7 isoform X1.	0.752