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NOTCH2 NOTCH2 SULF2 SULF2 LAMB2 LAMB2 FOXJ1 FOXJ1 DCHS2 DCHS2 NUP107 NUP107 BMP7 BMP7 ENSTTRP00000014801 ENSTTRP00000014801 PKD1 PKD1 PTPRO PTPRO PKD2 PKD2 SALL1 SALL1 LZTS2 LZTS2 PAX2 PAX2 COL4A3 COL4A3 COL4A4 COL4A4 FGF8 FGF8 DLG2 DLG2 EXT1 EXT1 NUP85 NUP85 HEYL HEYL DLL1 DLL1 SIX1 SIX1 SHH SHH LGR4 LGR4 WNT11 WNT11 PLCE1 PLCE1 NPHS2 NPHS2 GREB1 GREB1 CALB1 CALB1 WT1 WT1 DLG1 DLG1 EYA1 EYA1 PDGFRA PDGFRA NID1 NID1 PAX8 PAX8 SMAD4 SMAD4 WNK4 WNK4 GZF1 GZF1 SULF1 SULF1 LAMA5 LAMA5 ENSTTRP00000010363 ENSTTRP00000010363 FMN1 FMN1 PTCH1 PTCH1 TMEM59L TMEM59L ERBB4 ERBB4 WNT6 WNT6 OSR1 OSR1 ENSTTRP00000009296 ENSTTRP00000009296 NUP133 NUP133 TCF21 TCF21 BMP4 BMP4 LHX1 LHX1 SMO SMO ENSTTRP00000007731 ENSTTRP00000007731 ASXL1 ASXL1 NOTCH1 NOTCH1 TACSTD2 TACSTD2 ADAMTS16 ADAMTS16 AQP11 AQP11 JAG1 JAG1 IRX2 IRX2 CTNNB1 CTNNB1 HS3ST3B1 HS3ST3B1 MTSS1 MTSS1 GPC3 GPC3 KIRREL3 KIRREL3 SOX8 SOX8 SOX9 SOX9 EGR1 EGR1 ITGA3 ITGA3 KIF26B KIF26B MYO1E MYO1E AHI1 AHI1 BCL2 BCL2 GATA3 GATA3 IQGAP1 IQGAP1 NPNT NPNT DCHS1 DCHS1 ILK ILK PECAM1 PECAM1 GREB1L GREB1L FGF1 FGF1 WNT1 WNT1 ACTA2 ACTA2 MEF2C MEF2C NPHS1 NPHS1 TFAP2B TFAP2B WNT9B WNT9B GLI3 GLI3 HOXA11 HOXA11 WWTR1 WWTR1 CTNNBIP1 CTNNBIP1 PROM1 PROM1 BMP2 BMP2 EDNRA EDNRA GDNF GDNF HES1 HES1 EDNRB EDNRB UMOD UMOD SIX2 SIX2 SEC61A1 SEC61A1 ENSTTRP00000000737 ENSTTRP00000000737 KLHL3 KLHL3 NUP160 NUP160 aqp1 aqp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
SULF2Sulfatase 2. (847 aa)
LAMB2Laminin subunit beta-2. (1803 aa)
FOXJ1Forkhead box protein J1. (389 aa)
DCHS2Protocadherin-23. (2854 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (914 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
ENSTTRP00000014801annotation not available (387 aa)
PKD1Polycystin-1 isoform X3. (4289 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1181 aa)
PKD2Polycystin-2 isoform X2. (975 aa)
SALL1Spalt like transcription factor 1. (1316 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (668 aa)
PAX2LOW QUALITY PROTEIN: paired box protein Pax-2. (419 aa)
COL4A3Collagen alpha-3(IV) chain. (1658 aa)
COL4A4Collagen alpha-4(IV) chain. (1684 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
DLG2Disks large homolog 2 isoform X2. (966 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (323 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
SIX1Homeobox protein SIX1. (284 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (908 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
PLCE1Phosphoinositide phospholipase C. (2294 aa)
NPHS2Podocin isoform X1. (323 aa)
GREB1Growth regulating estrogen receptor binding 1. (1943 aa)
CALB1Calbindin. (261 aa)
WT1Wilms tumor protein isoform X2. (336 aa)
DLG1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (920 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1040 aa)
NID1Nidogen-1. (1238 aa)
PAX8Paired box protein Pax-8. (445 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
WNK4WNK lysine deficient protein kinase 4. (1193 aa)
GZF1LOW QUALITY PROTEIN: GDNF-inducible zinc finger protein 1. (718 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
LAMA5Laminin subunit alpha-5-like. (3506 aa)
ENSTTRP00000010363annotation not available (1047 aa)
FMN1Formin-1. (648 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
TMEM59LTransmembrane protein 59-like. (289 aa)
ERBB4Receptor protein-tyrosine kinase. (1299 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
ENSTTRP00000009296annotation not available (181 aa)
NUP133Nuclear pore complex protein Nup133 isoform X1. (1155 aa)
TCF21Transcription factor 21. (162 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
ENSTTRP00000007731annotation not available (287 aa)
ASXL1Putative Polycomb group protein ASXL1 isoform X1. (1526 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (201 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16. (1163 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (471 aa)
CTNNB1Catenin beta-1. (781 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (357 aa)
MTSS1Metastasis suppressor protein 1 isoform X2. (758 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (597 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (755 aa)
SOX8Transcription factor SOX-8. (445 aa)
SOX9Transcription factor SOX-9. (509 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
ITGA3Integrin subunit alpha 3. (1068 aa)
KIF26BKinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2101 aa)
MYO1EUnconventional myosin-Ie; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1107 aa)
AHI1Jouberin isoform X1. (1168 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1658 aa)
NPNTNephronectin isoform X2. (560 aa)
DCHS1Protocadherin-16. (3134 aa)
ILKIntegrin-linked protein kinase. (450 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X2. (420 aa)
GREB1LGREB1-like protein. (871 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ACTA2Actin, aortic smooth muscle. (378 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1240 aa)
TFAP2BTranscription factor AP-2-beta isoform X4. (360 aa)
WNT9BWnt family member 9B. (330 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
HOXA11Homeobox protein Hox-A11. (311 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
CTNNBIP1Beta-catenin-interacting protein 1 isoform X1. (176 aa)
PROM1Prominin-1. (845 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X2. (211 aa)
HES1Transcription factor HES-1. (280 aa)
EDNRBEndothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (530 aa)
UMODUromodulin. (657 aa)
SIX2Homeobox protein SIX2. (168 aa)
SEC61A1Protein transport protein Sec61 subunit alpha isoform X2. (451 aa)
ENSTTRP00000000737annotation not available (355 aa)
KLHL3Kelch-like protein 3. (587 aa)
NUP160Nuclear pore complex protein Nup160 isoform X1. (1432 aa)
aqp1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (251 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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