STRINGSTRING
TGFB1 TGFB1 NOTCH2 NOTCH2 aqp1 aqp1 KLHL3 KLHL3 EPHA4 EPHA4 ENSTTRP00000000737 ENSTTRP00000000737 SFRP1 SFRP1 SIX2 SIX2 UMOD UMOD EDNRB EDNRB RET RET HES1 HES1 GDNF GDNF EDNRA EDNRA BMP2 BMP2 PROM1 PROM1 SMAD3 SMAD3 CTNNBIP1 CTNNBIP1 HOXA11 HOXA11 BMPER BMPER GLI3 GLI3 WNT9B WNT9B TFAP2B TFAP2B NPHS1 NPHS1 MEF2C MEF2C SMAD7 SMAD7 WNT1 WNT1 FGF1 FGF1 GREB1L GREB1L PECAM1 PECAM1 ILK ILK DCHS1 DCHS1 NPNT NPNT IQGAP1 IQGAP1 GATA3 GATA3 BCL2 BCL2 AHI1 AHI1 MYO1E MYO1E KIF26B KIF26B SOX9 SOX9 SLIT2 SLIT2 SOX8 SOX8 GPC3 GPC3 MTSS1 MTSS1 HS3ST3B1 HS3ST3B1 CTNNB1 CTNNB1 IRX2 IRX2 JAG1 JAG1 AQP11 AQP11 ADAMTS16 ADAMTS16 TACSTD2 TACSTD2 NOTCH1 NOTCH1 ASXL1 ASXL1 CER1 CER1 SMAD1 SMAD1 ENSTTRP00000007731 ENSTTRP00000007731 SMO SMO LHX1 LHX1 BMP4 BMP4 TCF21 TCF21 GDF11 GDF11 ENSTTRP00000009296 ENSTTRP00000009296 OSR1 OSR1 WNT6 WNT6 SMAD6 SMAD6 CRLF1 CRLF1 TMEM59L TMEM59L RARB RARB PTCH1 PTCH1 FMN1 FMN1 ENSTTRP00000010363 ENSTTRP00000010363 LAMA5 LAMA5 GZF1 GZF1 WNK4 WNK4 SMAD4 SMAD4 PAX8 PAX8 EYA1 EYA1 DLG1 DLG1 WT1 WT1 CALB1 CALB1 GREB1 GREB1 NPHS2 NPHS2 WNT11 WNT11 LGR4 LGR4 SHH SHH SIX1 SIX1 DLL1 DLL1 HEYL HEYL EXT1 EXT1 DLG2 DLG2 FGF8 FGF8 PAX2 PAX2 LZTS2 LZTS2 SALL1 SALL1 SPRY1 SPRY1 PKD2 PKD2 PTPRO PTPRO PKD1 PKD1 ENSTTRP00000014801 ENSTTRP00000014801 BMP7 BMP7 KANK2 KANK2 ARG2 ARG2 FOXJ1 FOXJ1 EPHA7 EPHA7 SMAD5 SMAD5 RARA RARA LAMB2 LAMB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta 1. (338 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
aqp1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (251 aa)
KLHL3Kelch-like protein 3. (587 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (979 aa)
ENSTTRP00000000737annotation not available (355 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
SIX2Homeobox protein SIX2. (168 aa)
UMODUromodulin. (657 aa)
EDNRBEndothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (530 aa)
RETRet proto-oncogene. (1113 aa)
HES1Transcription factor HES-1. (280 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X2. (211 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
PROM1Prominin-1. (845 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
CTNNBIP1Beta-catenin-interacting protein 1 isoform X1. (176 aa)
HOXA11Homeobox protein Hox-A11. (311 aa)
BMPERBMP-binding endothelial regulator protein. (640 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
WNT9BWnt family member 9B. (330 aa)
TFAP2BTranscription factor AP-2-beta isoform X4. (360 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1240 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
SMAD7Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GREB1LGREB1-like protein. (871 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X2. (420 aa)
ILKIntegrin-linked protein kinase. (450 aa)
DCHS1Protocadherin-16. (3134 aa)
NPNTNephronectin isoform X2. (560 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1658 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
AHI1Jouberin isoform X1. (1168 aa)
MYO1EUnconventional myosin-Ie; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1107 aa)
KIF26BKinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2101 aa)
SOX9Transcription factor SOX-9. (509 aa)
SLIT2Slit homolog 2 protein isoform X2. (1470 aa)
SOX8Transcription factor SOX-8. (445 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (597 aa)
MTSS1Metastasis suppressor protein 1 isoform X2. (758 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (357 aa)
CTNNB1Catenin beta-1. (781 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (471 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16. (1163 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (201 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
ASXL1Putative Polycomb group protein ASXL1 isoform X1. (1526 aa)
CER1Cerberus. (271 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ENSTTRP00000007731annotation not available (287 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
TCF21Transcription factor 21. (162 aa)
GDF11Growth differentiation factor 11. (313 aa)
ENSTTRP00000009296annotation not available (181 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
SMAD6SMAD family member 6. (492 aa)
CRLF1Cytokine receptor like factor 1. (382 aa)
TMEM59LTransmembrane protein 59-like. (289 aa)
RARBRetinoic acid receptor beta. (522 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
FMN1Formin-1. (648 aa)
ENSTTRP00000010363annotation not available (1047 aa)
LAMA5Laminin subunit alpha-5-like. (3506 aa)
GZF1LOW QUALITY PROTEIN: GDNF-inducible zinc finger protein 1. (718 aa)
WNK4WNK lysine deficient protein kinase 4. (1193 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
PAX8Paired box protein Pax-8. (445 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
DLG1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (920 aa)
WT1Wilms tumor protein isoform X2. (336 aa)
CALB1Calbindin. (261 aa)
GREB1Growth regulating estrogen receptor binding 1. (1943 aa)
NPHS2Podocin isoform X1. (323 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (908 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
SIX1Homeobox protein SIX1. (284 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (323 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
DLG2Disks large homolog 2 isoform X2. (966 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
PAX2LOW QUALITY PROTEIN: paired box protein Pax-2. (419 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (668 aa)
SALL1Spalt like transcription factor 1. (1316 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
PKD2Polycystin-2 isoform X2. (975 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1181 aa)
PKD1Polycystin-1 isoform X3. (4289 aa)
ENSTTRP00000014801annotation not available (387 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2. (739 aa)
ARG2Arginase. (317 aa)
FOXJ1Forkhead box protein J1. (389 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
RARARetinoic acid receptor alpha-like. (618 aa)
LAMB2Laminin subunit beta-2. (1803 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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