STRINGSTRING
DLG2 DLG2 SIX1 SIX1 SHH SHH LGR4 LGR4 WNT11 WNT11 EYA1 EYA1 SALL1 SALL1 PKD2 PKD2 PKD1 PKD1 PAX8 PAX8 SMAD4 SMAD4 WNK4 WNK4 GZF1 GZF1 LAMA5 LAMA5 ENSTTRP00000010363 ENSTTRP00000010363 KLHL3 KLHL3 SIX2 SIX2 HES1 HES1 GDNF GDNF ENSTTRP00000000737 ENSTTRP00000000737 GREB1 GREB1 WT1 WT1 ENSTTRP00000014801 ENSTTRP00000014801 DLG1 DLG1 LZTS2 LZTS2 PAX2 PAX2 TCF21 TCF21 OSR1 OSR1 WNT6 WNT6 TMEM59L TMEM59L PTCH1 PTCH1 FMN1 FMN1 LHX1 LHX1 SMO SMO ENSTTRP00000007731 ENSTTRP00000007731 TACSTD2 TACSTD2 ADAMTS16 ADAMTS16 IRX2 IRX2 CTNNB1 CTNNB1 HS3ST3B1 HS3ST3B1 GPC3 GPC3 SOX8 SOX8 SOX9 SOX9 KIF26B KIF26B AHI1 AHI1 BCL2 BCL2 GATA3 GATA3 NPNT NPNT BMP4 BMP4 DCHS1 DCHS1 ILK ILK GREB1L GREB1L FGF1 FGF1 WNT1 WNT1 WNT9B WNT9B GLI3 GLI3 HOXA11 HOXA11 CTNNBIP1 CTNNBIP1 BMP2 BMP2 FGF8 FGF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLG2Disks large homolog 2 isoform X2. (966 aa)
SIX1Homeobox protein SIX1. (284 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (908 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
SALL1Spalt like transcription factor 1. (1316 aa)
PKD2Polycystin-2 isoform X2. (975 aa)
PKD1Polycystin-1 isoform X3. (4289 aa)
PAX8Paired box protein Pax-8. (445 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
WNK4WNK lysine deficient protein kinase 4. (1193 aa)
GZF1LOW QUALITY PROTEIN: GDNF-inducible zinc finger protein 1. (718 aa)
LAMA5Laminin subunit alpha-5-like. (3506 aa)
ENSTTRP00000010363annotation not available (1047 aa)
KLHL3Kelch-like protein 3. (587 aa)
SIX2Homeobox protein SIX2. (168 aa)
HES1Transcription factor HES-1. (280 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X2. (211 aa)
ENSTTRP00000000737annotation not available (355 aa)
GREB1Growth regulating estrogen receptor binding 1. (1943 aa)
WT1Wilms tumor protein isoform X2. (336 aa)
ENSTTRP00000014801annotation not available (387 aa)
DLG1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (920 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (668 aa)
PAX2LOW QUALITY PROTEIN: paired box protein Pax-2. (419 aa)
TCF21Transcription factor 21. (162 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
TMEM59LTransmembrane protein 59-like. (289 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
FMN1Formin-1. (648 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
ENSTTRP00000007731annotation not available (287 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (201 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16. (1163 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (471 aa)
CTNNB1Catenin beta-1. (781 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (357 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (597 aa)
SOX8Transcription factor SOX-8. (445 aa)
SOX9Transcription factor SOX-9. (509 aa)
KIF26BKinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2101 aa)
AHI1Jouberin isoform X1. (1168 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
NPNTNephronectin isoform X2. (560 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
DCHS1Protocadherin-16. (3134 aa)
ILKIntegrin-linked protein kinase. (450 aa)
GREB1LGREB1-like protein. (871 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT9BWnt family member 9B. (330 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
HOXA11Homeobox protein Hox-A11. (311 aa)
CTNNBIP1Beta-catenin-interacting protein 1 isoform X1. (176 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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