(9 nodes) Epithelial cell fate commitment network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	PROX1	Prospero homeobox protein 1. (744 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (337 aa)
	NKX2-2	Homeobox protein Nkx-2.2. (271 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	SOSTDC1	Sclerostin domain-containing protein 1. (229 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
	RARA	Retinoic acid receptor alpha-like. (618 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	ENSTTRP00000009296	ENSTTRP00000013215	ENSTTRP00000009296	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.846
DLL1	NEUROD1	ENSTTRP00000013215	ENSTTRP00000015887	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic differentiation factor.	0.483
DLL1	NOTCH1	ENSTTRP00000013215	ENSTTRP00000007173	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1.	0.996
ENSTTRP00000009296	DLL1	ENSTTRP00000009296	ENSTTRP00000013215	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.846
NEUROD1	DLL1	ENSTTRP00000015887	ENSTTRP00000013215	Neurogenic differentiation factor.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.483
NEUROD1	NKX2-2	ENSTTRP00000015887	ENSTTRP00000008666	Neurogenic differentiation factor.	Homeobox protein Nkx-2.2.	0.620
NKX2-2	NEUROD1	ENSTTRP00000008666	ENSTTRP00000015887	Homeobox protein Nkx-2.2.	Neurogenic differentiation factor.	0.620
NOTCH1	DLL1	ENSTTRP00000007173	ENSTTRP00000013215	Neurogenic locus notch homolog protein 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.996