(15 nodes) Ureter development network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RET	Ret proto-oncogene. (1113 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	EMX2	Homeobox protein EMX2. (252 aa)
	SOX9	Transcription factor SOX-9. (509 aa)
	TBX18	T-box transcription factor TBX18. (612 aa)
	FOXF1	Forkhead box F1. (372 aa)
	SOX8	Transcription factor SOX-8. (445 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	OSR1	Protein odd-skipped-related 1. (267 aa)
	NFIA	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (532 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (668 aa)
	NPHP3	Nephrocystin-3 isoform X1. (1356 aa)
	ALDH1A2	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	TBX18	ENSTTRP00000002211	ENSTTRP00000005395	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	T-box transcription factor TBX18.	0.499
BMP4	FOXF1	ENSTTRP00000008787	ENSTTRP00000005561	Bone morphogenetic protein 4.	Forkhead box F1.	0.555
BMP4	GATA3	ENSTTRP00000008787	ENSTTRP00000004761	Bone morphogenetic protein 4.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.403
BMP4	SOX9	ENSTTRP00000008787	ENSTTRP00000005370	Bone morphogenetic protein 4.	Transcription factor SOX-9.	0.664
BMP4	TBX18	ENSTTRP00000008787	ENSTTRP00000005395	Bone morphogenetic protein 4.	T-box transcription factor TBX18.	0.527
FOXF1	BMP4	ENSTTRP00000005561	ENSTTRP00000008787	Forkhead box F1.	Bone morphogenetic protein 4.	0.555
FOXF1	SOX9	ENSTTRP00000005561	ENSTTRP00000005370	Forkhead box F1.	Transcription factor SOX-9.	0.448
GATA3	BMP4	ENSTTRP00000004761	ENSTTRP00000008787	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Bone morphogenetic protein 4.	0.403
GATA3	LHX1	ENSTTRP00000004761	ENSTTRP00000008440	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	LIM/homeobox protein Lhx1.	0.494
GATA3	SIX1	ENSTTRP00000004761	ENSTTRP00000013114	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Homeobox protein SIX1.	0.416
LHX1	GATA3	ENSTTRP00000008440	ENSTTRP00000004761	LIM/homeobox protein Lhx1.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.494
LHX1	SIX1	ENSTTRP00000008440	ENSTTRP00000013114	LIM/homeobox protein Lhx1.	Homeobox protein SIX1.	0.562
NFIA	SOX9	ENSTTRP00000010640	ENSTTRP00000005370	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	Transcription factor SOX-9.	0.563
RET	SIX1	ENSTTRP00000001522	ENSTTRP00000013114	Ret proto-oncogene.	Homeobox protein SIX1.	0.475
SIX1	GATA3	ENSTTRP00000013114	ENSTTRP00000004761	Homeobox protein SIX1.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.416
SIX1	LHX1	ENSTTRP00000013114	ENSTTRP00000008440	Homeobox protein SIX1.	LIM/homeobox protein Lhx1.	0.562
SIX1	RET	ENSTTRP00000013114	ENSTTRP00000001522	Homeobox protein SIX1.	Ret proto-oncogene.	0.475
SOX9	BMP4	ENSTTRP00000005370	ENSTTRP00000008787	Transcription factor SOX-9.	Bone morphogenetic protein 4.	0.664
SOX9	FOXF1	ENSTTRP00000005370	ENSTTRP00000005561	Transcription factor SOX-9.	Forkhead box F1.	0.448
SOX9	NFIA	ENSTTRP00000005370	ENSTTRP00000010640	Transcription factor SOX-9.	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	0.563