STRINGSTRING
EIF4E EIF4E CPEB2 CPEB2 BOLL BOLL EIF2B3 EIF2B3 EIF2B5 EIF2B5 AGO2 AGO2 MRPL58 MRPL58 EEF1G EEF1G EIF5 EIF5 EIF3M EIF3M EIF1AX EIF1AX TUFM TUFM EIF2B2 EIF2B2 GFM1 GFM1 EIF3A EIF3A ENSTTRP00000000955 ENSTTRP00000000955 EEFSEC EEFSEC MTRF1L MTRF1L EIF1B EIF1B HBS1L HBS1L EIF3H EIF3H EIF3J EIF3J EEF1D EEF1D EIF3B EIF3B EIF4G2 EIF4G2 EIF4E1B EIF4E1B MTIF2 MTIF2 SHMT2 SHMT2 CPEB1 CPEB1 EEF1B2 EEF1B2 ENSTTRP00000012002 ENSTTRP00000012002 EIF2B4 EIF2B4 EIF2S3 EIF2S3 CPEB3 CPEB3 PAIP2B PAIP2B EIF2D EIF2D GSPT1 GSPT1 PURA PURA EIF4G3 EIF4G3 EIF4G1 EIF4G1 EIF3E EIF3E EIF4E2 EIF4E2 GSPT2 GSPT2 EIF3K EIF3K EIF5B EIF5B MTRF1 MTRF1 EIF4A1 EIF4A1 EIF5A EIF5A EIF3I EIF3I PAIP1 PAIP1 EIF1AD EIF1AD EIF4H EIF4H DHX29 DHX29 MTIF3 MTIF3 TSFM TSFM SHMT1 SHMT1 EIF2A EIF2A EEF1E1 EEF1E1 EIF2B1 EIF2B1 MCTS1 MCTS1 EIF5A2 EIF5A2 EIF2AK2 EIF2AK2 EEF2 EEF2 EIF3D EIF3D EIF2S2 EIF2S2 GTPBP2 GTPBP2 ELOB ELOB EIF2S1 EIF2S1 DENR DENR C12orf65 C12orf65 LARP1 LARP1 ELOA ELOA EIF3F EIF3F EIF4A2 EIF4A2 EIF6 EIF6 ABTB1 ABTB1 EIF1 EIF1 ENSTTRP00000005606 ENSTTRP00000005606 LOC101326477 LOC101326477 GTPBP1 GTPBP1 ETF1 ETF1 EIF4E3 EIF4E3 CPEB4 CPEB4 EIF3L EIF3L CTIF CTIF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4EEukaryotic translation initiation factor 4E isoform X2; Belongs to the eukaryotic initiation factor 4E family. (211 aa)
CPEB2Cytoplasmic polyadenylation element-binding protein 2 isoform X1. (480 aa)
BOLLProtein boule-like isoform X1. (334 aa)
EIF2B3Translation initiation factor eIF-2B subunit gamma. (451 aa)
EIF2B5Translation initiation factor eIF-2B subunit epsilon. (726 aa)
AGO2Argonaute RISC catalytic component 2. (852 aa)
MRPL58peptidyl-tRNA hydrolase ICT1, mitochondrial. (206 aa)
EEF1GElongation factor 1-gamma. (436 aa)
EIF5Eukaryotic translation initiation factor 5. (356 aa)
EIF3MEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (374 aa)
EIF1AXEukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (144 aa)
TUFMElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (275 aa)
EIF2B2Translation initiation factor eIF-2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (316 aa)
GFM1Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...] (755 aa)
EIF3AEukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (1346 aa)
ENSTTRP00000000955annotation not available (700 aa)
EEFSECSelenocysteine-specific elongation factor isoform X1. (585 aa)
MTRF1LPeptide chain release factor 1-like, mitochondrial isoform X1. (378 aa)
EIF1BEukaryotic translation initiation factor 1B. (113 aa)
HBS1LHBS1-like protein isoform X2. (683 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa)
EIF3JEukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (189 aa)
EEF1DEukaryotic translation elongation factor 1 delta. (643 aa)
EIF3BEukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (843 aa)
EIF4G2Eukaryotic translation initiation factor 4 gamma 2. (903 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B. (210 aa)
MTIF2Translation initiation factor IF-2, mitochondrial isoform X1. (727 aa)
SHMT2Serine hydroxymethyltransferase, mitochondrial. (502 aa)
CPEB1Cytoplasmic polyadenylation element-binding protein 1. (561 aa)
EEF1B2Elongation factor 1-beta isoform X1; Belongs to the EF-1-beta/EF-1-delta family. (225 aa)
ENSTTRP00000012002annotation not available (307 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta. (524 aa)
EIF2S3Eukaryotic translation initiation factor 2 subunit 3 isoform X1. (472 aa)
CPEB3Cytoplasmic polyadenylation element-binding protein 3 isoform X1. (690 aa)
PAIP2BPolyadenylate-binding protein-interacting protein 2B. (121 aa)
EIF2DEukaryotic translation initiation factor 2D isoform X1. (584 aa)
GSPT1Eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1. (707 aa)
PURATranscriptional activator protein Pur-alpha. (325 aa)
EIF4G3Eukaryotic translation initiation factor 4 gamma 3 isoform X4. (1581 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1537 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
GSPT2Eukaryotic peptide chain release factor GTP-binding subunit ERF3B. (632 aa)
EIF3KEukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (198 aa)
EIF5BEukaryotic translation initiation factor 5B isoform X6. (1220 aa)
MTRF1Peptide chain release factor 1, mitochondrial isoform X2. (446 aa)
EIF4A1Eukaryotic initiation factor 4A-I isoform X1; Belongs to the DEAD box helicase family. (406 aa)
EIF5AEukaryotic translation initiation factor 5A. (161 aa)
EIF3IEukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (323 aa)
PAIP1Polyadenylate-binding protein-interacting protein 1 isoform X1. (480 aa)
EIF1ADEukaryotic translation initiation factor 1A domain containing. (165 aa)
EIF4HEukaryotic translation initiation factor 4H isoform X1. (156 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1367 aa)
MTIF3Translation initiation factor IF-3, mitochondrial isoform X1. (278 aa)
TSFMElongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (328 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
EIF2AEukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (608 aa)
EEF1E1Eukaryotic translation elongation factor 1 epsilon-1 isoform X1. (173 aa)
EIF2B1Translation initiation factor eIF-2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (305 aa)
MCTS1Malignant T-cell-amplified sequence. (182 aa)
EIF5A2Eukaryotic translation initiation factor 5A. (153 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (539 aa)
EEF2Elongation factor 2. (858 aa)
EIF3DEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required [...] (546 aa)
EIF2S2Eukaryotic translation initiation factor 2 subunit 2. (322 aa)
GTPBP2GTP binding protein 2. (602 aa)
ELOBTranscription elongation factor B polypeptide 2. (151 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
DENRDensity-regulated protein; Belongs to the DENR family. (199 aa)
C12orf65Probable peptide chain release factor C12orf65 homolog, mitochondrial isoform X2. (165 aa)
LARP1La-related protein 1 isoform X2. (954 aa)
ELOATranscription elongation factor B polypeptide 3 isoform X1. (747 aa)
EIF3FEukaryotic translation initiation factor 3 subunit F. (355 aa)
EIF4A2Eukaryotic translation initiation factor 4A2. (407 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
ABTB1Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X4. (453 aa)
EIF1Eukaryotic translation initiation factor 1. (113 aa)
ENSTTRP00000005606annotation not available (454 aa)
LOC101326477Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (913 aa)
GTPBP1GTP-binding protein 1 isoform X1. (669 aa)
ETF1Eukaryotic peptide chain release factor subunit 1 isoform X1. (415 aa)
EIF4E3Eukaryotic translation initiation factor 4E type 3 isoform X2; Belongs to the eukaryotic initiation factor 4E family. (165 aa)
CPEB4Cytoplasmic polyadenylation element-binding protein 4 isoform X1. (729 aa)
EIF3LEukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (594 aa)
CTIFCBP80/20-dependent translation initiation factor. (600 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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