STRINGSTRING
ENSTTRP00000009296 ENSTTRP00000009296 TPBG TPBG SFRP1 SFRP1 AMER1 AMER1 RUVBL2 RUVBL2 PRICKLE1 PRICKLE1 SCYL2 SCYL2 HDAC1 HDAC1 APC APC CTNND1 CTNND1 TCF7L2 TCF7L2 FRZB FRZB BMP2 BMP2 PTPRU PTPRU SLC9A3R1 SLC9A3R1 TLE3 TLE3 PFDN5 PFDN5 CTNNBIP1 CTNNBIP1 WWTR1 WWTR1 GLI3 GLI3 SFRP4 SFRP4 TMEM131L TMEM131L SFRP2 SFRP2 OTUD5 OTUD5 LMBR1L LMBR1L SOX10 SOX10 WNT5A WNT5A DKKL1 DKKL1 EGR1 EGR1 FUZ FUZ CBY1 CBY1 SOX9 SOX9 GPC3 GPC3 LATS1 LATS1 CTNNB1 CTNNB1 TLE4 TLE4 FZD4 FZD4 RBMS3 RBMS3 STK3 STK3 TLE6 TLE6 ENSTTRP00000006944 ENSTTRP00000006944 ANKRD6 ANKRD6 TLE5 TLE5 SIAH2 SIAH2 NOTCH1 NOTCH1 STK4 STK4 JADE1 JADE1 GSK3A GSK3A CSNK1A1 CSNK1A1 CAV1 CAV1 APOE APOE SOX13 SOX13 DACT1 DACT1 G3BP1 G3BP1 AXIN1 AXIN1 RAPGEF1 RAPGEF1 DKK2 DKK2 AXIN2 AXIN2 DAB2IP DAB2IP ENSTTRP00000009142 ENSTTRP00000009142 SOSTDC1 SOSTDC1 LATS2 LATS2 SFRP5 SFRP5 MLLT3 MLLT3 MAD2L2 MAD2L2 ENSTTRP00000009560 ENSTTRP00000009560 TMEM88 TMEM88 LIMD1 LIMD1 TNN TNN DKK3 DKK3 ISL1 ISL1 SDHAF2 SDHAF2 DAB2 DAB2 KREMEN1 KREMEN1 PRKN PRKN NOTUM NOTUM UBAC2 UBAC2 TMEM170B TMEM170B FERMT1 FERMT1 GLI1 GLI1 DDIT3 DDIT3 WNT11 WNT11 NKD1 NKD1 AMFR AMFR CCDC88C CCDC88C SHH SHH EMD EMD LRP4 LRP4 APC2 APC2 NPHP4 NPHP4 ENSTTRP00000014050 ENSTTRP00000014050 STK11 STK11 LZTS2 LZTS2 CYLD CYLD PTPRO PTPRO NPHP3 NPHP3 ENSTTRP00000014726 ENSTTRP00000014726 FZD6 FZD6 CTHRC1 CTHRC1 TLE1 TLE1 CHD8 CHD8 SHISA3 SHISA3 GSK3B GSK3B INVS INVS FOXO3 FOXO3 FRMD8 FRMD8 BICC1 BICC1 MCC MCC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSTTRP00000009296annotation not available (181 aa)
TPBGTrophoblast glycoprotein. (415 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
AMER1APC membrane recruitment protein 1. (1114 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (443 aa)
PRICKLE1Prickle-like protein 1. (832 aa)
SCYL2SCY1-like protein 2 isoform X1. (926 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
APCAdenomatous polyposis coli protein isoform X2. (2845 aa)
CTNND1Catenin delta-1 isoform X1. (964 aa)
TCF7L2Transcription factor 7-like 2 isoform X5. (639 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
PTPRUReceptor-type tyrosine-protein phosphatase U. (1446 aa)
SLC9A3R1SLC9A3 regulator 1. (359 aa)
TLE3Transducin-like enhancer protein 3. (768 aa)
PFDN5Prefoldin subunit 5. (154 aa)
CTNNBIP1Beta-catenin-interacting protein 1 isoform X1. (176 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
SFRP4Secreted frizzled-related protein 4 isoform X1. (285 aa)
TMEM131LTransmembrane protein 131-like isoform X1. (1458 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
OTUD5OTU domain-containing protein 5 isoform X4. (568 aa)
LMBR1LProtein LMBR1L isoform X1; Belongs to the LIMR family. (487 aa)
SOX10Transcription factor SOX-10. (468 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
DKKL1Dickkopf-like protein 1 isoform X1. (209 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
FUZFuzzy planar cell polarity protein. (419 aa)
CBY1Protein chibby homolog 1 isoform X3. (127 aa)
SOX9Transcription factor SOX-9. (509 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (597 aa)
LATS1Serine/threonine-protein kinase LATS1. (958 aa)
CTNNB1Catenin beta-1. (781 aa)
TLE4Transducin-like enhancer protein 4 isoform X2. (790 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
RBMS3RNA-binding motif, single-stranded-interacting protein 3 isoform X1. (435 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (480 aa)
TLE6Transducin-like enhancer protein 6. (448 aa)
ENSTTRP00000006944annotation not available (743 aa)
ANKRD6Ankyrin repeat domain 6. (725 aa)
TLE5TLE family member 5, transcriptional modulator. (256 aa)
SIAH2Siah E3 ubiquitin protein ligase 2. (185 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (435 aa)
JADE1Protein Jade-1 isoform X1. (841 aa)
GSK3AGlycogen synthase kinase-3 alpha. (483 aa)
CSNK1A1Casein kinase I isoform X3; Belongs to the protein kinase superfamily. (324 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (134 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (316 aa)
SOX13SRY-box transcription factor 13. (621 aa)
DACT1Dapper homolog 1. (745 aa)
G3BP1Ras GTPase-activating protein-binding protein 1. (465 aa)
AXIN1Axin-1 isoform X2. (866 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1090 aa)
DKK2Dickkopf-related protein 2. (259 aa)
AXIN2Axin-2-like. (839 aa)
DAB2IPDAB2 interacting protein. (1177 aa)
ENSTTRP00000009142annotation not available (224 aa)
SOSTDC1Sclerostin domain-containing protein 1. (229 aa)
LATS2Large tumor suppressor kinase 2. (992 aa)
SFRP5Secreted frizzled-related protein 5. (252 aa)
MLLT3Protein AF-9. (567 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (223 aa)
ENSTTRP00000009560annotation not available (199 aa)
TMEM88Transmembrane protein 88. (159 aa)
LIMD1LIM domain-containing protein 1 isoform X1. (654 aa)
TNNtenascin-N. (1241 aa)
DKK3Dickkopf-related protein 3. (282 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (153 aa)
DAB2Disabled homolog 2 isoform X2. (753 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (431 aa)
PRKN1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (465 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (327 aa)
UBAC2Ubiquitin-associated domain-containing protein 2 isoform X2. (345 aa)
TMEM170BTransmembrane protein 170B. (108 aa)
FERMT1Fermitin family homolog 1 isoform X1. (677 aa)
GLI1Zinc finger protein GLI1. (1106 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (167 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
NKD1Protein naked cuticle homolog 1. (468 aa)
AMFRE3 ubiquitin-protein ligase AMFR isoform X1. (558 aa)
CCDC88CCoiled-coil domain containing 88C. (1937 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
EMDEmerin isoform X2. (255 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1924 aa)
APC2Adenomatous polyposis coli protein 2-like. (2262 aa)
NPHP4Nephrocystin-4. (1429 aa)
ENSTTRP00000014050annotation not available (239 aa)
STK11Serine/threonine-protein kinase STK11 isoform X3. (340 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (668 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (956 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1181 aa)
NPHP3Nephrocystin-3 isoform X1. (1356 aa)
ENSTTRP00000014726annotation not available (263 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (707 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (197 aa)
TLE1Transducin-like enhancer protein 1 isoform X5. (768 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2299 aa)
SHISA3Protein shisa-3 homolog. (238 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
INVSInversin isoform X1. (1065 aa)
FOXO3Forkhead box protein O3. (612 aa)
FRMD8FERM domain-containing protein 8 isoform X1. (460 aa)
BICC1Protein bicaudal C homolog 1. (909 aa)
MCCColorectal mutant cancer protein isoform X1. (964 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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