STRINGSTRING
TGFB2 TGFB2 SRF SRF MRTFB MRTFB TEAD1 TEAD1 SOX9 SOX9 EGR1 EGR1 PPARD PPARD SMARCA4 SMARCA4 SMAD6 SMAD6 NFIB NFIB LOC101333926 LOC101333926 ETS1 ETS1 ATOH8 ATOH8 PDGFB PDGFB MYOCD MYOCD BMP2 BMP2 NR1H2 NR1H2 RELA RELA TERT TERT REST REST HDAC4 HDAC4 SMAD3 SMAD3 STAT3 STAT3 NGFR NGFR SMAD1 SMAD1 BMPR1A BMPR1A MYC MYC KLF5 KLF5 PPARA PPARA BMP4 BMP4 NFATC4 NFATC4 RARA RARA FOSL1 FOSL1 FOXO3 FOXO3 MRTFA MRTFA GNL3 GNL3 GATA3 GATA3 JUN JUN SREBF2 SREBF2 NFATC3 NFATC3 SMAD4 SMAD4 ZNF512 ZNF512 HIF1A HIF1A WT1 WT1 ZNF512B ZNF512B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
SRFSerum response factor isoform X2. (509 aa)
MRTFBMKL/myocardin-like protein 2 isoform X3. (969 aa)
TEAD1Transcriptional enhancer factor TEF-1 isoform X4. (426 aa)
SOX9Transcription factor SOX-9. (509 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
SMARCA4Transcription activator BRG1. (1644 aa)
SMAD6SMAD family member 6. (492 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
LOC101333926RE1-silencing transcription factor-like. (974 aa)
ETS1Protein C-ets-1. (485 aa)
ATOH8Protein atonal homolog 8. (411 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
MYOCDMyocardin isoform X1. (968 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (446 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1124 aa)
RESTRE1-silencing transcription factor. (656 aa)
HDAC4Histone deacetylase 4. (1065 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
KLF5Krueppel-like factor 5. (370 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (469 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
NFATC4Nuclear factor of activated T cells 4. (746 aa)
RARARetinoic acid receptor alpha-like. (618 aa)
FOSL1Fos-related antigen 1. (271 aa)
FOXO3Forkhead box protein O3. (612 aa)
MRTFAPhosphatase and actin regulator. (925 aa)
GNL3Guanine nucleotide-binding protein-like 3 isoform X2. (341 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (321 aa)
SREBF2Sterol regulatory element-binding protein 2. (1029 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1071 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
ZNF512Zinc finger protein 512 isoform X1. (566 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (824 aa)
WT1Wilms tumor protein isoform X2. (336 aa)
ZNF512BZinc finger protein 512B. (884 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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