(44 nodes) Positive regulation of protein localization to plasma membrane network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGA3	Integrin subunit alpha 3. (1068 aa)
	ANXA13	Annexin. (353 aa)
	CNST	Consortin isoform X1. (720 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2374 aa)
	SQSTM1	Sequestosome-1. (440 aa)
	R3HDM1	R3H domain-containing protein 1 isoform X5. (1096 aa)
	CLIP3	CAP-Gly domain-containing linker protein 3. (547 aa)
	RER1	Retention in endoplasmic reticulum sorting receptor 1. (196 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (705 aa)
	LGALS3	Galectin. (252 aa)
	ATP2C1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (959 aa)
	SPTBN5	Spectrin beta chain, non-erythrocytic 5-like. (3477 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2 isoform X2. (168 aa)
	ZDHHC5	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	EPHA3	Ephrin type-A receptor 3 isoform X1. (984 aa)
	KIF5B	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (921 aa)
	R3HDM2	R3H domain-containing protein 2 isoform X2. (1034 aa)
	RANGRF	RAN guanine nucleotide release factor. (186 aa)
	CIB1	Calcium and integrin binding 1. (191 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1208 aa)
	DPP10	Inactive dipeptidyl peptidase 10; Belongs to the peptidase S9B family. (799 aa)
	EGFR	Receptor protein-tyrosine kinase. (1211 aa)
	EPHA2	Ephrin type-A receptor 2-like. (974 aa)
	VIL1	Villin 1. (825 aa)
	WNK3	Serine/threonine-protein kinase WNK3 isoform X1. (1759 aa)
	EZR	Ezrin isoform X1. (582 aa)
	DLG1	Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (920 aa)
	LRP1	Prolow-density lipoprotein receptor-related protein 1. (4544 aa)
	STAC3	SH3 and cysteine-rich domain-containing protein 3 isoform X1. (340 aa)
	ENSTTRP00000006381	annotation not available (382 aa)
	RACK1	Receptor of activated protein C kinase 1. (346 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
	CNPY4	Protein canopy homolog 4. (195 aa)
	STAC	SH3 and cysteine-rich domain-containing protein. (402 aa)
	STX3	Syntaxin-3; Belongs to the syntaxin family. (289 aa)
	RAMP3	Receptor activity-modifying protein 3. (151 aa)
	AGR2	Anterior gradient protein 2 homolog. (182 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	PLS1	Plastin-1. (628 aa)
	ACSL3	long-chain-fatty-acid--CoA ligase 3 isoform X1. (720 aa)
	ENSTTRP00000014050	annotation not available (239 aa)
	DLG2	Disks large homolog 2 isoform X2. (966 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL3	CLIP3	ENSTTRP00000009614	ENSTTRP00000003685	long-chain-fatty-acid--CoA ligase 3 isoform X1.	CAP-Gly domain-containing linker protein 3.	0.557
ARHGEF16	EPHA2	ENSTTRP00000003219	ENSTTRP00000016478	Rho guanine nucleotide exchange factor 16.	Ephrin type-A receptor 2-like.	0.493
ARHGEF16	RER1	ENSTTRP00000003219	ENSTTRP00000003523	Rho guanine nucleotide exchange factor 16.	Retention in endoplasmic reticulum sorting receptor 1.	0.515
ATP2B4	ATP2C1	ENSTTRP00000015619	ENSTTRP00000002767	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.612
ATP2C1	ATP2B4	ENSTTRP00000002767	ENSTTRP00000015619	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.612
CLIP3	ACSL3	ENSTTRP00000003685	ENSTTRP00000009614	CAP-Gly domain-containing linker protein 3.	long-chain-fatty-acid--CoA ligase 3 isoform X1.	0.557
CLIP3	PDPK1	ENSTTRP00000003685	ENSTTRP00000007797	CAP-Gly domain-containing linker protein 3.	3-phosphoinositide-dependent protein kinase 1 isoform X1.	0.588
DLG1	DLG2	ENSTTRP00000011781	ENSTTRP00000013949	Disks large homolog 1 isoform X3; Belongs to the MAGUK family.	Disks large homolog 2 isoform X2.	0.898
DLG1	PDPK1	ENSTTRP00000011781	ENSTTRP00000007797	Disks large homolog 1 isoform X3; Belongs to the MAGUK family.	3-phosphoinositide-dependent protein kinase 1 isoform X1.	0.476
DLG2	DLG1	ENSTTRP00000013949	ENSTTRP00000011781	Disks large homolog 2 isoform X2.	Disks large homolog 1 isoform X3; Belongs to the MAGUK family.	0.898
DLG2	PDPK1	ENSTTRP00000013949	ENSTTRP00000007797	Disks large homolog 2 isoform X2.	3-phosphoinositide-dependent protein kinase 1 isoform X1.	0.476
EGFR	EPHA2	ENSTTRP00000016375	ENSTTRP00000016478	Receptor protein-tyrosine kinase.	Ephrin type-A receptor 2-like.	0.721
EGFR	EZR	ENSTTRP00000016375	ENSTTRP00000010759	Receptor protein-tyrosine kinase.	Ezrin isoform X1.	0.628
EGFR	ITGB1	ENSTTRP00000016375	ENSTTRP00000009434	Receptor protein-tyrosine kinase.	Integrin beta; Belongs to the integrin beta chain family.	0.750
EGFR	LGALS3	ENSTTRP00000016375	ENSTTRP00000003114	Receptor protein-tyrosine kinase.	Galectin.	0.652
EGFR	LRP1	ENSTTRP00000016375	ENSTTRP00000012407	Receptor protein-tyrosine kinase.	Prolow-density lipoprotein receptor-related protein 1.	0.506
EGFR	PIK3R1	ENSTTRP00000016375	ENSTTRP00000015369	Receptor protein-tyrosine kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.988
ENSTTRP00000006381	LRP1	ENSTTRP00000006381	ENSTTRP00000012407	annotation not available	Prolow-density lipoprotein receptor-related protein 1.	0.548
EPHA2	ARHGEF16	ENSTTRP00000016478	ENSTTRP00000003219	Ephrin type-A receptor 2-like.	Rho guanine nucleotide exchange factor 16.	0.493
EPHA2	EGFR	ENSTTRP00000016478	ENSTTRP00000016375	Ephrin type-A receptor 2-like.	Receptor protein-tyrosine kinase.	0.721