STRINGSTRING
MCRS1 MCRS1 PARP1 PARP1 KMT5C KMT5C FMR1 FMR1 EP400 EP400 SHLD1 SHLD1 RUVBL1 RUVBL1 RUVBL2 RUVBL2 FBH1 FBH1 KHDC3L KHDC3L OOEP OOEP EPC1 EPC1 ZNF385A ZNF385A SIRT6 SIRT6 MFSD11 MFSD11 HDGFL2 HDGFL2 MRGBP MRGBP SKIL SKIL ACTB ACTB TRIM28 TRIM28 UIMC1 UIMC1 PRKCD PRKCD BCLAF1 BCLAF1 BCL7A BCL7A BABAM1 BABAM1 ANKLE1 ANKLE1 KMT5B KMT5B SPIRE1 SPIRE1 EYA2 EYA2 NSMCE4A NSMCE4A RNF8 RNF8 MGMT MGMT ERCC8 ERCC8 MRNIP MRNIP FAM168A FAM168A ENSTTRP00000004331 ENSTTRP00000004331 ARID2 ARID2 ZNHIT1 ZNHIT1 HELQ HELQ ABRAXAS1 ABRAXAS1 SPIRE2 SPIRE2 PBK PBK BRD8 BRD8 FOXM1 FOXM1 INO80E INO80E RPS3 RPS3 ATM ATM WDR48 WDR48 ENSTTRP00000006211 ENSTTRP00000006211 SLF1 SLF1 PIAS4 PIAS4 VPS72 VPS72 TIMELESS TIMELESS EEF1E1 EEF1E1 NACC2 NACC2 MBTD1 MBTD1 EYA3 EYA3 TMEM161A TMEM161A DHX9 DHX9 FAM35A FAM35A BRCC3 BRCC3 SPIDR SPIDR ENSTTRP00000007825 ENSTTRP00000007825 SMCHD1 SMCHD1 PRKDC PRKDC UBE2V2 UBE2V2 MEAF6 MEAF6 DDX5 DDX5 ZCWPW1 ZCWPW1 ACTL6A ACTL6A NSMCE1 NSMCE1 NFRKB NFRKB UCHL5 UCHL5 RBBP8 RBBP8 MMS19 MMS19 ATR ATR MAD2L2 MAD2L2 PAXIP1 PAXIP1 FXR2 FXR2 WRAP53 WRAP53 FGF10 FGF10 ENSTTRP00000010223 ENSTTRP00000010223 PRKCG PRKCG PLA2R1 PLA2R1 RAD51AP1 RAD51AP1 RIF1 RIF1 MORF4L2 MORF4L2 POGZ POGZ INO80 INO80 ENDOG ENDOG BRCA1 BRCA1 ING4 ING4 CCDC117 CCDC117 FANCB FANCB HDAC10 HDAC10 NKX3-1 NKX3-1 EYA1 EYA1 BABAM2 BABAM2 RNF168 RNF168 CCAR2 CCAR2 INO80D INO80D TTI2 TTI2 DMAP1 DMAP1 RAD9A RAD9A SPRED1 SPRED1 PARP9 PARP9 DTX3L DTX3L ENSTTRP00000013212 ENSTTRP00000013212 YEATS4 YEATS4 EPC2 EPC2 FXR1 FXR1 ANKRD1 ANKRD1 ERCC6 ERCC6 XRCC1 XRCC1 PNKP PNKP SLF2 SLF2 PCNA PCNA MAP3K20 MAP3K20 BCL7C BCL7C FUS FUS ING3 ING3 SIRT1 SIRT1 MYC MYC NPAS2 NPAS2 TIGAR TIGAR EYA4 EYA4 ENSTTRP00000016047 ENSTTRP00000016047 EGFR EGFR ACTR8 ACTR8 PARP3 PARP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCRS1LOW QUALITY PROTEIN: microspherule protein 1. (472 aa)
PARP1Poly [ADP-ribose] polymerase 1. (1011 aa)
KMT5CHistone-lysine N-methyltransferase KMT5C. (455 aa)
FMR1Synaptic functional regulator FMR1 isoform X1. (597 aa)
EP400E1A-binding protein p400. (3093 aa)
SHLD1Uncharacterized protein C20orf196 homolog isoform X1. (206 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (454 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (443 aa)
FBH1F-box DNA helicase 1 isoform X2. (1074 aa)
KHDC3LKHDC3-like protein. (218 aa)
OOEPOocyte-expressed protein homolog isoform X2. (140 aa)
EPC1Enhancer of polycomb homolog 1 isoform X3. (772 aa)
ZNF385AZinc finger protein 385A. (338 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X5. (245 aa)
MFSD11UNC93-like protein MFSD11. (449 aa)
HDGFL2Hepatoma-derived growth factor-related protein 2 isoform X1. (664 aa)
MRGBPMRG domain binding protein. (204 aa)
SKILSki-like protein isoform X1. (681 aa)
ACTBActin beta. (375 aa)
TRIM28Transcription intermediary factor 1-beta. (720 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (720 aa)
PRKCDProtein kinase C delta. (671 aa)
BCLAF1Bcl-2-associated transcription factor 1 isoform X1. (921 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (231 aa)
BABAM1BRISC and BRCA1-A complex member 1 isoform X1. (367 aa)
ANKLE1Ankyrin repeat and LEM domain-containing protein 1. (603 aa)
KMT5BHistone-lysine N-methyltransferase KMT5B isoform X1. (882 aa)
SPIRE1Protein spire homolog 1. (583 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (542 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (450 aa)
MGMTmethylated-DNA--protein-cysteine methyltransferase. (211 aa)
ERCC8DNA excision repair protein ERCC-8 isoform X1. (396 aa)
MRNIPUPF0544 protein C5orf45 homolog isoform X4. (339 aa)
FAM168AProtein FAM168A isoform X1. (207 aa)
ENSTTRP00000004331annotation not available (458 aa)
ARID2AT-rich interactive domain-containing protein 2 isoform X2. (1772 aa)
ZNHIT1Zinc finger HIT-type containing 1. (154 aa)
HELQHelicase POLQ-like isoform X1. (1104 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas isoform X1. (410 aa)
SPIRE2Spire type actin nucleation factor 2. (716 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (198 aa)
BRD8Bromodomain-containing protein 8 isoform X4. (1233 aa)
FOXM1Forkhead box protein M1 isoform X2. (795 aa)
INO80EINO80 complex subunit E. (243 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa)
WDR48WD repeat-containing protein 48 isoform X2. (677 aa)
ENSTTRP00000006211annotation not available (252 aa)
SLF1SMC5-SMC6 complex localization factor protein 1 isoform X1. (895 aa)
PIAS4Protein inhibitor of activated STAT 4. (461 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog. (374 aa)
TIMELESSProtein timeless homolog isoform X2. (1200 aa)
EEF1E1Eukaryotic translation elongation factor 1 epsilon-1 isoform X1. (173 aa)
NACC2Nucleus accumbens-associated protein 2. (418 aa)
MBTD1MBT domain-containing protein 1 isoform X9. (631 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
TMEM161ALOW QUALITY PROTEIN: transmembrane protein 161A. (342 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1153 aa)
FAM35AProtein FAM35A isoform X1. (545 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36 isoform X1. (317 aa)
SPIDRDNA repair-scaffolding protein isoform X1. (900 aa)
ENSTTRP00000007825annotation not available (269 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1353 aa)
PRKDCDNA-dependent protein kinase catalytic subunit-like isoform X2; Belongs to the PI3/PI4-kinase family. (4120 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
MEAF6Chromatin modification-related protein MEAF6. (201 aa)
DDX5Probable ATP-dependent RNA helicase DDX5. (614 aa)
ZCWPW1Zinc finger CW-type PWWP domain protein 1 isoform X1. (644 aa)
ACTL6AActin-like protein 6A; Belongs to the actin family. (429 aa)
NSMCE1Non-structural maintenance of chromosomes element 1 homolog. (266 aa)
NFRKBNuclear factor related to kappa-B-binding protein. (1320 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (331 aa)
RBBP8DNA endonuclease RBBP8 isoform X2. (846 aa)
MMS19MMS19 nucleotide excision repair protein homolog. (1030 aa)
ATRSerine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2623 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (223 aa)
PAXIP1PAX-interacting protein 1 isoform X5. (1017 aa)
FXR2Fragile X mental retardation syndrome-related protein 2 isoform X1. (695 aa)
WRAP53Telomerase Cajal body protein 1 isoform X1. (540 aa)
FGF10Fibroblast growth factor 10. (142 aa)
ENSTTRP00000010223annotation not available (1723 aa)
PRKCGProtein kinase C gamma type. (697 aa)
PLA2R1Secretory phospholipase A2 receptor. (1462 aa)
RAD51AP1RAD51-associated protein 1 isoform X1. (345 aa)
RIF1Telomere-associated protein RIF1. (2463 aa)
MORF4L2Mortality factor 4 like 2. (157 aa)
POGZPogo transposable element with ZNF domain isoform X1. (1410 aa)
INO80DNA helicase INO80 isoform X1. (1536 aa)
ENDOGEndonuclease G. (291 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa)
ING4Inhibitor of growth protein. (247 aa)
CCDC117Coiled-coil domain-containing protein 117. (277 aa)
FANCBFanconi anemia group B protein. (861 aa)
HDAC10Histone deacetylase 10. (671 aa)
NKX3-1Homeobox protein Nkx-3.1. (138 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
BABAM2BRCA1-A complex subunit BRE. (411 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X3. (916 aa)
INO80DINO80 complex subunit D isoform X1. (803 aa)
TTI2TELO2-interacting protein 2. (508 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
RAD9ARAD9 checkpoint clamp component A. (390 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (436 aa)
PARP9Poly [ADP-ribose] polymerase 9. (845 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (738 aa)
ENSTTRP00000013212annotation not available (243 aa)
YEATS4YEATS domain-containing protein 4. (227 aa)
EPC2Enhancer of polycomb homolog. (805 aa)
FXR1Fragile X mental retardation syndrome-related protein 1 isoform X3. (620 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (318 aa)
ERCC6DNA excision repair protein ERCC-6 isoform X2. (1483 aa)
XRCC1DNA repair protein XRCC1 isoform X1. (598 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (519 aa)
SLF2SMC5-SMC6 complex localization factor protein 2 isoform X3. (1186 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (187 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform X1. (800 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (159 aa)
FUSRNA-binding protein FUS. (506 aa)
ING3Inhibitor of growth protein. (413 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (616 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
NPAS2Neuronal PAS domain-containing protein 2. (806 aa)
TIGARLOW QUALITY PROTEIN: fructose-2,6-bisphosphatase TIGAR-like. (269 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
ENSTTRP00000016047annotation not available (460 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (620 aa)
PARP3Poly [ADP-ribose] polymerase. (534 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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