STRINGSTRING
FGF10 FGF10 HGF HGF PHIP PHIP COL2A1 COL2A1 IL7 IL7 FAIM2 FAIM2 CTNNA1 CTNNA1 LMNA LMNA BIRC6 BIRC6 PEA15 PEA15 ITPRIP ITPRIP DDX3X DDX3X GDNF GDNF RELA RELA LGALS3 LGALS3 TNFAIP3 TNFAIP3 EYA2 EYA2 GFRAL GFRAL TERT TERT CTTN CTTN GCLM GCLM AR AR SFRP2 SFRP2 GATA1 GATA1 BCL2 BCL2 SRC SRC ENSTTRP00000005802 ENSTTRP00000005802 FAIM FAIM PELI3 PELI3 SH3RF1 SH3RF1 CSF2 CSF2 HMOX1 HMOX1 EYA3 EYA3 SIAH2 SIAH2 CFLAR CFLAR ZC3HC1 ZC3HC1 IFI6 IFI6 BMP4 BMP4 STRADB STRADB FGB FGB ENSTTRP00000009720 ENSTTRP00000009720 IL1B IL1B ITGA6 ITGA6 YAP1 YAP1 PSME3 PSME3 BRCA1 BRCA1 IL19 IL19 FGG FGG EYA1 EYA1 ITGAV ITGAV TMBIM1 TMBIM1 TGFBR1 TGFBR1 PAK5 PAK5 RNF34 RNF34 HTT HTT RB1CC1 RB1CC1 RFFL RFFL PARK7 PARK7 ZMYND11 ZMYND11 GSK3B GSK3B EYA4 EYA4 UNC5B UNC5B SGK3 SGK3 RPS6KB1 RPS6KB1 IGF1 IGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF10Fibroblast growth factor 10. (142 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (727 aa)
PHIPPH-interacting protein isoform X1. (1822 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
FAIM2Fas apoptotic inhibitory molecule 2. (316 aa)
CTNNA1Catenin alpha-1 isoform X1. (924 aa)
LMNALamin A/C. (664 aa)
BIRC6LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6. (4817 aa)
PEA15Astrocytic phosphoprotein PEA-15. (149 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein. (596 aa)
DDX3XATP-dependent RNA helicase DDX3X; Belongs to the DEAD box helicase family. (645 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X2. (211 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
LGALS3Galectin. (252 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (542 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (385 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1124 aa)
CTTNSrc substrate cortactin isoform X3. (456 aa)
GCLMGlutamate--cysteine ligase regulatory subunit isoform X1. (274 aa)
ARAndrogen receptor. (886 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
GATA1Erythroid transcription factor. (383 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
ENSTTRP00000005802annotation not available (670 aa)
FAIMFas apoptotic inhibitory molecule 1 isoform X2. (142 aa)
PELI3LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase pellino homolog 3. (469 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1 isoform X2. (840 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
SIAH2Siah E3 ubiquitin protein ligase 2. (185 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (482 aa)
ZC3HC1Nuclear-interacting partner of ALK isoform X2. (479 aa)
IFI6Interferon alpha-inducible protein 6 isoform X1. (125 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
FGBFibrinogen beta chain. (490 aa)
ENSTTRP00000009720annotation not available (206 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1130 aa)
YAP1Transcriptional coactivator YAP1 isoform X4. (488 aa)
PSME3Proteasome activator subunit 3. (268 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa)
IL19Interleukin-19. (214 aa)
FGGFibrinogen gamma chain isoform X1. (457 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1095 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1. (308 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (375 aa)
HTTHuntingtin. (3104 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X4. (1518 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X6. (356 aa)
PARK7Protein deglycase DJ-1. (189 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X2. (601 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
UNC5BNetrin receptor UNC5B-like. (945 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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