(28 nodes) Regulation of extrinsic apoptotic signaling pathway in absence of ligand network (Tursiops truncatus)

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	HTRA2	Serine protease HTRA2, mitochondrial. (457 aa)
	PPP1CA	Protein phosphatase 1 catalytic subunit alpha. (321 aa)
	NF1	Neurofibromin. (2814 aa)
	WWOX	WW domain-containing oxidoreductase isoform X2. (522 aa)
	EYA4	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
	UNC5B	Netrin receptor UNC5B-like. (945 aa)
	SGK3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	COL2A1	Collagen type II alpha 1 chain. (1487 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
	CTNNA1	Catenin alpha-1 isoform X1. (924 aa)
	GDNF	Glial cell line-derived neurotrophic factor isoform X2. (211 aa)
	INHBA	Inhibin beta A chain. (421 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (542 aa)
	GFRAL	LOW QUALITY PROTEIN: GDNF family receptor alpha-like. (385 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1124 aa)
	GATA1	Erythroid transcription factor. (383 aa)
	SRPX	Sushi repeat-containing protein SRPX isoform X1. (467 aa)
	BCL2	Apoptosis regulator Bcl-2 isoform X1. (233 aa)
	ENSTTRP00000005802	annotation not available (670 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (144 aa)
	EYA3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
	ZC3HC1	Nuclear-interacting partner of ALK isoform X2. (479 aa)
	IFI6	Interferon alpha-inducible protein 6 isoform X1. (125 aa)
	STRADB	STE20-related kinase adapter protein beta isoform X1. (418 aa)
	FGF10	Fibroblast growth factor 10. (142 aa)
	PPP2R1B	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (664 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CSF2	ENSTTRP00000004766	ENSTTRP00000006597	Apoptosis regulator Bcl-2 isoform X1.	Granulocyte-macrophage colony-stimulating factor.	0.471
BCL2	HTRA2	ENSTTRP00000004766	ENSTTRP00000012074	Apoptosis regulator Bcl-2 isoform X1.	Serine protease HTRA2, mitochondrial.	0.505
BCL2	IL1B	ENSTTRP00000004766	ENSTTRP00000010490	Apoptosis regulator Bcl-2 isoform X1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.707
BCL2	IL7	ENSTTRP00000004766	ENSTTRP00000000864	Apoptosis regulator Bcl-2 isoform X1.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.541
BCL2	TERT	ENSTTRP00000004766	ENSTTRP00000003636	Apoptosis regulator Bcl-2 isoform X1.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.485
COL2A1	IL1B	ENSTTRP00000000695	ENSTTRP00000010490	Collagen type II alpha 1 chain.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.544
CSF2	BCL2	ENSTTRP00000006597	ENSTTRP00000004766	Granulocyte-macrophage colony-stimulating factor.	Apoptosis regulator Bcl-2 isoform X1.	0.471
CSF2	FGF10	ENSTTRP00000006597	ENSTTRP00000009805	Granulocyte-macrophage colony-stimulating factor.	Fibroblast growth factor 10.	0.505
CSF2	IL1B	ENSTTRP00000006597	ENSTTRP00000010490	Granulocyte-macrophage colony-stimulating factor.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.969
CSF2	IL7	ENSTTRP00000006597	ENSTTRP00000000864	Granulocyte-macrophage colony-stimulating factor.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.760
ENSTTRP00000005802	IL1B	ENSTTRP00000005802	ENSTTRP00000010490	annotation not available	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.442
ENSTTRP00000005802	SGK3	ENSTTRP00000005802	ENSTTRP00000016253	annotation not available	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.441
EYA1	EYA2	ENSTTRP00000011780	ENSTTRP00000003587	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.565
EYA1	EYA3	ENSTTRP00000011780	ENSTTRP00000007106	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.569
EYA1	EYA4	ENSTTRP00000011780	ENSTTRP00000015934	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.578
EYA1	GDNF	ENSTTRP00000011780	ENSTTRP00000001982	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Glial cell line-derived neurotrophic factor isoform X2.	0.718
EYA2	EYA1	ENSTTRP00000003587	ENSTTRP00000011780	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.565
EYA2	EYA3	ENSTTRP00000003587	ENSTTRP00000007106	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.572
EYA2	EYA4	ENSTTRP00000003587	ENSTTRP00000015934	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.574
EYA3	EYA1	ENSTTRP00000007106	ENSTTRP00000011780	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.569