STRINGSTRING
PLEKHH1 PLEKHH1 SPEN SPEN CHEK1 CHEK1 FAM43A FAM43A MYBBP1A MYBBP1A EP400 EP400 SMARCD3 SMARCD3 PRIM2 PRIM2 BAZ1A BAZ1A SMARCD1 SMARCD1 POLE3 POLE3 CFDP1 CFDP1 PMF1 PMF1 KMT2E KMT2E EXOSC9 EXOSC9 HDAC1 HDAC1 GINS1 GINS1 MPND MPND RCC1 RCC1 ENSTTRP00000001764 ENSTTRP00000001764 MLH3 MLH3 TONSL TONSL RAD21 RAD21 SMARCA2 SMARCA2 SMARCB1 SMARCB1 TNKS1BP1 TNKS1BP1 SSRP1 SSRP1 DPF3 DPF3 ARID4B ARID4B SMARCC1 SMARCC1 CECR2 CECR2 POLD1 POLD1 MTA2 MTA2 EML3 EML3 FKBP6 FKBP6 BAZ1B BAZ1B BCL7B BCL7B SNPH SNPH HMGA2 HMGA2 CHRAC1 CHRAC1 SMARCA5 SMARCA5 ZMIZ2 ZMIZ2 NRG3 NRG3 BCL7A BCL7A RAD1 RAD1 ATP10D ATP10D MEGF6 MEGF6 GINS4 GINS4 SYCE2 SYCE2 SYCP2L SYCP2L C14orf39 C14orf39 ZRANB3 ZRANB3 MTA1 MTA1 PHF12 PHF12 CDYL CDYL ARID1B ARID1B ARID2 ARID2 RMI2 RMI2 ZNHIT1 ZNHIT1 ACTR6 ACTR6 ETAA1 ETAA1 SF3B4 SF3B4 POLA1 POLA1 BRD8 BRD8 ENSTTRP00000005081 ENSTTRP00000005081 INO80E INO80E ENSTTRP00000005232 ENSTTRP00000005232 MIS12 MIS12 DMC1 DMC1 SFR1 SFR1 POLD3 POLD3 NIFK NIFK POLD2 POLD2 MACROH2A1 MACROH2A1 SMARCA1 SMARCA1 BCL11A BCL11A ENSTTRP00000006211 ENSTTRP00000006211 LENG9 LENG9 MACROH2A2 MACROH2A2 BICRAL BICRAL SMARCD2 SMARCD2 RSF1 RSF1 DEK DEK TIMELESS TIMELESS SS18 SS18 RPA2 RPA2 BRMS1L BRMS1L POLE2 POLE2 ACTR5 ACTR5 TEX11 TEX11 SMC3 SMC3 ENSTTRP00000007825 ENSTTRP00000007825 SMCHD1 SMCHD1 MCM4 MCM4 GINS3 GINS3 SINHCAF SINHCAF BICRA BICRA PBRM1 PBRM1 REC8 REC8 ENSTTRP00000008237 ENSTTRP00000008237 BANF1 BANF1 RNF212B RNF212B C17orf64 C17orf64 ACTL6A ACTL6A ACTL6B ACTL6B ORC3 ORC3 BRD9 BRD9 DPF1 DPF1 NFRKB NFRKB SMARCA4 SMARCA4 SYCP1 SYCP1 SETD5 SETD5 ENSTTRP00000009436 ENSTTRP00000009436 SAP130 SAP130 POLE4 POLE4 MEI4 MEI4 TIPIN TIPIN CHD3 CHD3 CHD5 CHD5 TEX12 TEX12 RAD51 RAD51 POLE POLE ORC5 ORC5 ING1 ING1 MMS22L MMS22L PHF10 PHF10 REC114 REC114 SPO11 SPO11 BCL7C BCL7C ARHGAP17 ARHGAP17 RAD9B RAD9B HDAC2 HDAC2 SIN3B SIN3B CDC45 CDC45 NUFIP1 NUFIP1 MLH1 MLH1 GATAD2B GATAD2B ERCC6 ERCC6 BRMS1 BRMS1 SHOC1 SHOC1 MSH4 MSH4 SYCE3 SYCE3 BPTF BPTF CPSF6 CPSF6 SMARCE1 SMARCE1 HDAC3 HDAC3 CHD1 CHD1 RPA3 RPA3 SYCE1L SYCE1L ARID4A ARID4A BRD7 BRD7 HUS1 HUS1 RBBP7 RBBP7 ASH1L ASH1L ORC6 ORC6 RAD9A RAD9A SRCAP SRCAP DMAP1 DMAP1 TTI2 TTI2 INO80D INO80D INO80B INO80B MTA3 MTA3 WBP1L WBP1L ENSTTRP00000011926 ENSTTRP00000011926 NYNRIN NYNRIN SIRT7 SIRT7 BCL11B BCL11B TELO2 TELO2 ORC2 ORC2 ENSTTRP00000011105 ENSTTRP00000011105 INO80 INO80 SIN3A SIN3A HMGXB4 HMGXB4 SYCP2 SYCP2 RNF2 RNF2 HDAC11 HDAC11 MCM10 MCM10 SS18L1 SS18L1 WBP1 WBP1 ACTR8 ACTR8 VWC2 VWC2 DPF2 DPF2 LOC101316193 LOC101316193 SYCP3 SYCP3 SLX4 SLX4 ENSTTRP00000016047 ENSTTRP00000016047 LRIF1 LRIF1 TTI1 TTI1 MORF4L1 MORF4L1 SWI5 SWI5 SMARCC2 SMARCC2 ARID1A ARID1A ORC4 ORC4 DDX21 DDX21 BLM BLM ORC1 ORC1 CHD4 CHD4 SUPT16H SUPT16H GINS2 GINS2 SUDS3 SUDS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLEKHH1Pleckstrin homology domain-containing family H member 1. (1383 aa)
SPENMsx2-interacting protein isoform X1. (3627 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (475 aa)
FAM43AFamily with sequence similarity 43 member A. (428 aa)
MYBBP1AMyb-binding protein 1A. (1343 aa)
EP400E1A-binding protein p400. (3093 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (369 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (347 aa)
BAZ1ABromodomain adjacent to zinc finger domain protein 1A isoform X2. (1549 aa)
SMARCD1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1. (515 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
CFDP1Craniofacial development protein 1; May play a role during embryogenesis. (299 aa)
PMF1Polyamine-modulated factor 1 isoform X1. (219 aa)
KMT2EHistone-lysine N-methyltransferase 2E isoform X1. (1854 aa)
EXOSC9Exosome complex component RRP45. (456 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
GINS1DNA replication complex GINS protein PSF1 isoform X3. (196 aa)
MPNDMPN domain-containing protein. (324 aa)
RCC1Regulator of chromosome condensation isoform X1. (445 aa)
ENSTTRP00000001764annotation not available (98 aa)
MLH3DNA mismatch repair protein Mlh3 isoform X1. (1456 aa)
TONSLTonsoku-like protein. (1206 aa)
RAD21Double-strand-break repair protein rad21 homolog isoform X1. (630 aa)
SMARCA2Probable global transcription activator SNF2L2 isoform X1. (1573 aa)
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1. (387 aa)
TNKS1BP1182 kDa tankyrase-1-binding protein. (1707 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (708 aa)
DPF3Zinc finger protein DPF3. (212 aa)
ARID4BAT-rich interactive domain-containing protein 4B isoform X1. (1310 aa)
SMARCC1SWI/SNF complex subunit SMARCC1 isoform X1. (1102 aa)
CECR2Cat eye syndrome critical region protein 2 isoform X2. (1388 aa)
POLD1LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit. (1125 aa)
MTA2Metastasis-associated protein MTA2 isoform X1. (661 aa)
EML3EMAP like 3. (896 aa)
FKBP6Peptidylprolyl isomerase. (325 aa)
BAZ1BTyrosine-protein kinase BAZ1B. (1482 aa)
BCL7BB-cell CLL/lymphoma 7 protein family member B isoform X2. (202 aa)
SNPHSyntaphilin isoform X1. (478 aa)
HMGA2High mobility group protein HMGI-C. (83 aa)
CHRAC1Chromatin accessibility complex protein 1. (132 aa)
SMARCA5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (983 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (922 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform. (724 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (231 aa)
RAD1Cell cycle checkpoint protein RAD1 isoform X1. (278 aa)
ATP10DPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1320 aa)
MEGF6Fibulin-5-like. (1534 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
SYCE2Synaptonemal complex central element protein 2 isoform X4. (216 aa)
SYCP2LSynaptonemal complex protein 2-like isoform X2. (782 aa)
C14orf39Protein SIX6OS1. (583 aa)
ZRANB3DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1078 aa)
MTA1Metastasis associated 1. (694 aa)
PHF12PHD finger protein 12. (1003 aa)
CDYLChromodomain Y-like protein isoform X2. (604 aa)
ARID1BAT-rich interactive domain-containing protein 1B isoform X7. (1764 aa)
ARID2AT-rich interactive domain-containing protein 2 isoform X2. (1772 aa)
RMI2recQ-mediated genome instability protein 2. (77 aa)
ZNHIT1Zinc finger HIT-type containing 1. (154 aa)
ACTR6Actin-related protein 6; Belongs to the actin family. (396 aa)
ETAA1Ewing's tumor-associated antigen 1 isoform X2. (905 aa)
SF3B4LOW QUALITY PROTEIN: splicing factor 3B subunit 4-like. (424 aa)
POLA1DNA polymerase. (1467 aa)
BRD8Bromodomain-containing protein 8 isoform X4. (1233 aa)
ENSTTRP00000005081annotation not available (262 aa)
INO80EINO80 complex subunit E. (243 aa)
ENSTTRP00000005232annotation not available (259 aa)
MIS12Protein MIS12 homolog. (205 aa)
DMC1Meiotic recombination protein DMC1/LIM15 homolog; Belongs to the RecA family. (340 aa)
SFR1Swi5-dependent recombination DNA repair protein 1 homolog. (302 aa)
POLD3DNA polymerase delta subunit 3 isoform X1. (465 aa)
NIFKMKI67 FHA domain-interacting nucleolar phosphoprotein. (275 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
MACROH2A1Histone H2A; Belongs to the histone H2A family. (372 aa)
SMARCA1Probable global transcription activator SNF2L1. (984 aa)
BCL11AB-cell lymphoma/leukemia 11A isoform X1. (835 aa)
ENSTTRP00000006211annotation not available (252 aa)
LENG9Leukocyte receptor cluster member 9. (487 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
BICRALGLTSCR1-like protein. (1079 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (471 aa)
RSF1Remodeling and spacing factor 1 isoform X4. (1428 aa)
DEKProtein DEK. (423 aa)
TIMELESSProtein timeless homolog isoform X2. (1200 aa)
SS18Protein SSXT isoform X3. (418 aa)
RPA2Replication protein A 32 kDa subunit. (344 aa)
BRMS1LBreast cancer metastasis-suppressor 1-like protein isoform X2. (275 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
ACTR5Actin-related protein 5; Belongs to the actin family. (482 aa)
TEX11Testis-expressed sequence 11 protein. (909 aa)
SMC3Structural maintenance of chromosomes protein. (1215 aa)
ENSTTRP00000007825annotation not available (269 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1353 aa)
MCM4DNA helicase; Belongs to the MCM family. (692 aa)
GINS3DNA replication complex GINS protein PSF3. (216 aa)
SINHCAFProtein FAM60A. (221 aa)
BICRAGlioma tumor suppressor candidate region gene 1 protein-like isoform X1. (1513 aa)
PBRM1Protein polybromo-1 isoform X2. (1684 aa)
REC8Meiotic recombination protein REC8 homolog. (546 aa)
ENSTTRP00000008237annotation not available (172 aa)
BANF1Barrier-to-autointegration factor. (89 aa)
RNF212BRING finger protein 212B. (300 aa)
C17orf64LOW QUALITY PROTEIN: uncharacterized protein C17orf64 homolog. (261 aa)
ACTL6AActin-like protein 6A; Belongs to the actin family. (429 aa)
ACTL6BActin-like protein 6B; Belongs to the actin family. (416 aa)
ORC3Origin recognition complex subunit 3 isoform X3. (714 aa)
BRD9Bromodomain-containing protein 9 isoform X1. (498 aa)
DPF1Zinc finger protein neuro-d4. (348 aa)
NFRKBNuclear factor related to kappa-B-binding protein. (1320 aa)
SMARCA4Transcription activator BRG1. (1644 aa)
SYCP1Synaptonemal complex protein 1. (945 aa)
SETD5SET domain-containing protein 5 isoform X9. (1457 aa)
ENSTTRP00000009436annotation not available (137 aa)
SAP130Histone deacetylase complex subunit SAP130 isoform X6. (1044 aa)
POLE4LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 4. (116 aa)
MEI4Meiosis-specific protein MEI4-like. (385 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (297 aa)
CHD3chromodomain-helicase-DNA-binding protein 3 isoform X1. (1963 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1917 aa)
TEX12Testis-expressed sequence 12 protein. (74 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2262 aa)
ORC5Origin recognition complex subunit 5 isoform X1. (376 aa)
ING1Inhibitor of growth protein. (258 aa)
MMS22LProtein MMS22-like isoform X1. (1233 aa)
PHF10PHD finger protein 10 isoform X1. (409 aa)
REC114REC114 meiotic recombination protein. (267 aa)
SPO11Meiotic recombination protein SPO11 isoform X1. (406 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (159 aa)
ARHGAP17Rho GTPase-activating protein 17 isoform X1. (873 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (583 aa)
SIN3BPaired amphipathic helix protein Sin3b-like. (1112 aa)
CDC45Cell division control protein 45 homolog. (567 aa)
NUFIP1Nuclear fragile X mental retardation-interacting protein 1. (494 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (689 aa)
GATAD2BTranscriptional repressor p66-beta isoform X4. (591 aa)
ERCC6DNA excision repair protein ERCC-6 isoform X2. (1483 aa)
BRMS1Breast cancer metastasis-suppressor 1 isoform X1. (245 aa)
SHOC1Uncharacterized protein C9orf84 homolog. (1504 aa)
MSH4mutS protein homolog 4. (909 aa)
SYCE3Synaptonemal complex central element protein 3. (89 aa)
BPTFNucleosome-remodeling factor subunit BPTF isoform X12. (2907 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6 isoform X2. (566 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
CHD1chromodomain-helicase-DNA-binding protein 1 isoform X4. (1708 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
SYCE1LSynaptonemal complex central element protein 1 like. (250 aa)
ARID4AAT-rich interactive domain-containing protein 4A isoform X2. (1258 aa)
BRD7Bromodomain-containing protein 7 isoform X1. (635 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (262 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X1. (2967 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
RAD9ARAD9 checkpoint clamp component A. (390 aa)
SRCAPHelicase SRCAP. (2614 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
TTI2TELO2-interacting protein 2. (508 aa)
INO80DINO80 complex subunit D isoform X1. (803 aa)
INO80BINO80 complex subunit B. (355 aa)
MTA3Metastasis-associated protein MTA3 isoform X2. (584 aa)
WBP1LLOW QUALITY PROTEIN: WW domain binding protein 1-like. (333 aa)
ENSTTRP00000011926annotation not available (149 aa)
NYNRINProtein NYNRIN. (484 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (400 aa)
BCL11BB-cell lymphoma/leukemia 11B. (897 aa)
TELO2Telomere length regulation protein TEL2 homolog. (824 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (496 aa)
ENSTTRP00000011105annotation not available (88 aa)
INO80DNA helicase INO80 isoform X1. (1536 aa)
SIN3APaired amphipathic helix protein Sin3a isoform X1. (1211 aa)
HMGXB4HMG domain-containing protein 4 isoform X1. (590 aa)
SYCP2Synaptonemal complex protein 2. (1501 aa)
RNF2E3 ubiquitin-protein ligase RING2 isoform X1. (336 aa)
HDAC11Histone deacetylase 11 isoform X1. (347 aa)
MCM10Protein MCM10 homolog. (872 aa)
SS18L1Calcium-responsive transactivator. (344 aa)
WBP1WW domain-binding protein 1. (300 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (620 aa)
VWC2Brorin isoform X1. (199 aa)
DPF2Zinc finger protein ubi-d4 isoform X2. (391 aa)
LOC101316193DNA polymerase alpha subunit B isoform X2. (597 aa)
SYCP3Synaptonemal complex protein 3 isoform X2. (235 aa)
SLX4Structure-specific endonuclease subunit SLX4. (1815 aa)
ENSTTRP00000016047annotation not available (460 aa)
LRIF1Ligand-dependent nuclear receptor-interacting factor 1 isoform X1. (761 aa)
TTI1TELO2-interacting protein 1 homolog isoform X1. (1092 aa)
MORF4L1Mortality factor 4-like protein 1 isoform X1. (362 aa)
SWI5DNA repair protein SWI5 homolog. (225 aa)
SMARCC2SWI/SNF complex subunit SMARCC2. (1177 aa)
ARID1ALOW QUALITY PROTEIN: AT-rich interactive domain-containing protein 1A. (2283 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
DDX21Nucleolar RNA helicase 2. (783 aa)
BLMBloom syndrome protein isoform X1. (1409 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1904 aa)
SUPT16HFACT complex subunit SPT16 isoform X1. (1046 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
SUDS3Sin3 histone deacetylase corepressor complex component SDS3 isoform X3. (329 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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