(31 nodes) mTORC1-mediated signalling network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPTOR	Regulatory-associated protein of mTOR-like. (1324 aa)
	LAMTOR5	Ragulator complex protein LAMTOR5. (159 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (248 aa)
	ENSTTRP00000002598	annotation not available (608 aa)
	EIF4EBP2	Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
	FKBP1A	Peptidylprolyl isomerase. (152 aa)
	RRAGD	Ras-related GTP-binding protein D. (395 aa)
	EIF4E	Eukaryotic translation initiation factor 4E isoform X2; Belongs to the eukaryotic initiation factor 4E family. (211 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
	RHEBL1	GTPase RhebL1 isoform X2. (183 aa)
	ENSTTRP00000005237	annotation not available (67 aa)
	YWHAB	14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
	EIF4B	Eukaryotic translation initiation factor 4B isoform X1. (68 aa)
	ENSTTRP00000007761	annotation not available (312 aa)
	SLC38A9	Sodium-coupled neutral amino acid transporter 9. (561 aa)
	RRAGC	Ras-related GTP-binding protein C. (399 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (722 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1537 aa)
	RRAGB	Ras-related GTP-binding protein A. (374 aa)
	LAMTOR2	Ragulator complex protein LAMTOR2. (150 aa)
	EIF4E1B	Eukaryotic translation initiation factor 4E family member 1B. (210 aa)
	AKT1S1	Proline-rich AKT1 substrate 1 isoform X1. (229 aa)
	LAMTOR3	Ragulator complex protein LAMTOR3 isoform X1. (100 aa)
	KIAA1671	Uncharacterized protein KIAA1671-like. (1798 aa)
	CRYBB3	Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (211 aa)
	TXNDC11	Thioredoxin domain-containing protein 11 isoform X3. (924 aa)
	CRYGN	Gamma-crystallin N; Belongs to the beta/gamma-crystallin family. (156 aa)
	RHEB	GTP-binding protein Rheb. (166 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	CRYBB3	ENSTTRP00000014166	ENSTTRP00000015647	Proline-rich AKT1 substrate 1 isoform X1.	Beta-crystallin B3; Belongs to the beta/gamma-crystallin family.	0.639
AKT1S1	CRYGN	ENSTTRP00000014166	ENSTTRP00000016168	Proline-rich AKT1 substrate 1 isoform X1.	Gamma-crystallin N; Belongs to the beta/gamma-crystallin family.	0.639
AKT1S1	EIF4E	ENSTTRP00000014166	ENSTTRP00000003956	Proline-rich AKT1 substrate 1 isoform X1.	Eukaryotic translation initiation factor 4E isoform X2; Belongs to the eukaryotic initiation factor 4E family.	0.671
AKT1S1	EIF4E1B	ENSTTRP00000014166	ENSTTRP00000013301	Proline-rich AKT1 substrate 1 isoform X1.	Eukaryotic translation initiation factor 4E family member 1B.	0.607
AKT1S1	EIF4EBP1	ENSTTRP00000014166	ENSTTRP00000004216	Proline-rich AKT1 substrate 1 isoform X1.	Eukaryotic translation initiation factor 4E binding protein 1.	0.926
AKT1S1	EIF4EBP2	ENSTTRP00000014166	ENSTTRP00000002982	Proline-rich AKT1 substrate 1 isoform X1.	Eukaryotic translation initiation factor 4E-binding protein 2.	0.622
AKT1S1	ENSTTRP00000007761	ENSTTRP00000014166	ENSTTRP00000007761	Proline-rich AKT1 substrate 1 isoform X1.	annotation not available	0.996
AKT1S1	KIAA1671	ENSTTRP00000014166	ENSTTRP00000015646	Proline-rich AKT1 substrate 1 isoform X1.	Uncharacterized protein KIAA1671-like.	0.639
AKT1S1	LAMTOR1	ENSTTRP00000014166	ENSTTRP00000010188	Proline-rich AKT1 substrate 1 isoform X1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.602
AKT1S1	LAMTOR2	ENSTTRP00000014166	ENSTTRP00000012659	Proline-rich AKT1 substrate 1 isoform X1.	Ragulator complex protein LAMTOR2.	0.599
AKT1S1	LAMTOR5	ENSTTRP00000014166	ENSTTRP00000001238	Proline-rich AKT1 substrate 1 isoform X1.	Ragulator complex protein LAMTOR5.	0.619
AKT1S1	MTOR	ENSTTRP00000014166	ENSTTRP00000001242	Proline-rich AKT1 substrate 1 isoform X1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.997
AKT1S1	RHEB	ENSTTRP00000014166	ENSTTRP00000016169	Proline-rich AKT1 substrate 1 isoform X1.	GTP-binding protein Rheb.	0.923
AKT1S1	RHEBL1	ENSTTRP00000014166	ENSTTRP00000004499	Proline-rich AKT1 substrate 1 isoform X1.	GTPase RhebL1 isoform X2.	0.686
AKT1S1	RPS6KB1	ENSTTRP00000014166	ENSTTRP00000016322	Proline-rich AKT1 substrate 1 isoform X1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.938
AKT1S1	RPTOR	ENSTTRP00000014166	ENSTTRP00000000521	Proline-rich AKT1 substrate 1 isoform X1.	Regulatory-associated protein of mTOR-like.	0.999
AKT1S1	RRAGB	ENSTTRP00000014166	ENSTTRP00000012021	Proline-rich AKT1 substrate 1 isoform X1.	Ras-related GTP-binding protein A.	0.952
AKT1S1	RRAGC	ENSTTRP00000014166	ENSTTRP00000009084	Proline-rich AKT1 substrate 1 isoform X1.	Ras-related GTP-binding protein C.	0.950
AKT1S1	RRAGD	ENSTTRP00000014166	ENSTTRP00000003463	Proline-rich AKT1 substrate 1 isoform X1.	Ras-related GTP-binding protein D.	0.929
AKT1S1	SLC38A9	ENSTTRP00000014166	ENSTTRP00000008833	Proline-rich AKT1 substrate 1 isoform X1.	Sodium-coupled neutral amino acid transporter 9.	0.729