STRINGSTRING
CLSPN CLSPN RAD9B RAD9B CDK3 CDK3 ORC1 ORC1 ORC4 ORC4 RFC4 RFC4 CDC6 CDC6 MCM2 MCM2 ATRIP ATRIP MCM7 MCM7 ORC2 ORC2 RFC3 RFC3 MCM10 MCM10 ORC5 ORC5 ATR ATR ORC3 ORC3 RFC2 RFC2 MCM4 MCM4 MCM5 MCM5 DBF4 DBF4 CDC7 CDC7 RCBTB2 RCBTB2 MCM3 MCM3 MCM6 MCM6 RAD1 RAD1 RAD17 RAD17 RPA1 RPA1 RFC5 RFC5 CHEK1 CHEK1 MCM8 MCM8 RCBTB1 RCBTB1 RAD9A RAD9A ORC6 ORC6 HUS1 HUS1 RPA3 RPA3 CDC45 CDC45 CDK2 CDK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLSPNClaspin. (1331 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
CDK3Cyclin dependent kinase 3. (304 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
RFC4Replication factor C subunit 4. (364 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
MCM2Minichromosome maintenance complex component 2. (905 aa)
ATRIPATR-interacting protein isoform X1. (790 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (496 aa)
RFC3Replication factor C subunit 3 isoform X2. (355 aa)
MCM10Protein MCM10 homolog. (872 aa)
ORC5Origin recognition complex subunit 5 isoform X1. (376 aa)
ATRSerine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2623 aa)
ORC3Origin recognition complex subunit 3 isoform X3. (714 aa)
RFC2Replication factor C subunit 2. (316 aa)
MCM4DNA helicase; Belongs to the MCM family. (692 aa)
MCM5DNA replication licensing factor MCM5-like. (734 aa)
DBF4Protein DBF4 homolog A isoform X1. (675 aa)
CDC7Cell division cycle 7-related protein kinase. (572 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (550 aa)
MCM3DNA helicase; Belongs to the MCM family. (801 aa)
MCM6DNA helicase; Belongs to the MCM family. (820 aa)
RAD1Cell cycle checkpoint protein RAD1 isoform X1. (278 aa)
RAD17Cell cycle checkpoint protein RAD17. (683 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
RFC5Replication factor C subunit 5. (341 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (475 aa)
MCM8DNA helicase MCM8 isoform X1; Belongs to the MCM family. (821 aa)
RCBTB1RCC1 and BTB domain-containing protein 1 isoform X2. (531 aa)
RAD9ARAD9 checkpoint clamp component A. (390 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (262 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
CDC45Cell division control protein 45 homolog. (567 aa)
CDK2Cyclin dependent kinase 2. (298 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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