STRINGSTRING
DBF4 DBF4 PPP2CB PPP2CB CDKN2B CDKN2B PPP2R1A PPP2R1A FNBP4 FNBP4 PSMB6 PSMB6 KIAA2012 KIAA2012 ENSTTRP00000000601 ENSTTRP00000000601 PSMA4 PSMA4 PSMC4 PSMC4 PRIM2 PRIM2 POLE3 POLE3 RPA1 RPA1 DYRK1A DYRK1A PSMB5 PSMB5 CCNA2 CCNA2 HDAC1 HDAC1 UBC UBC RBL1 RBL1 PRIM1 PRIM1 CDK7 CDK7 PSMD9 PSMD9 PPP2R3A PPP2R3A CKS2 CKS2 PSMA1 PSMA1 MCM6 MCM6 MCM3 MCM3 LIN37 LIN37 CCNA1 CCNA1 PSMC6 PSMC6 DYRK1B DYRK1B FNDC3A FNDC3A RB1 RB1 PSMB8 PSMB8 PSMB9 PSMB9 LOC101323346 LOC101323346 CDT1 CDT1 TFDP1 TFDP1 CCNE2 CCNE2 LIN9 LIN9 POLA1 POLA1 PSMA2 PSMA2 SRC SRC CDC7 CDC7 LIN52 LIN52 PSMD14 PSMD14 PSMD5 PSMD5 PSMB3 PSMB3 PSMC5 PSMC5 PSMD4 PSMD4 PPP4R4 PPP4R4 PSMB2 PSMB2 MCM5 MCM5 RPA2 RPA2 POLE2 POLE2 LIN54 LIN54 PPP2R3C PPP2R3C PSMA6 PSMA6 CDKN2D CDKN2D CCNE1 CCNE1 SKP2 SKP2 MCM4 MCM4 CDK4 CDK4 PSME1 PSME1 PSME2 PSME2 PRR5L PRR5L CABLES1 CABLES1 ORC3 ORC3 UBB UBB E2F3 E2F3 PSMB10 PSMB10 CDKN2C CDKN2C CCND3 CCND3 PSMA5 PSMA5 CDKN1C CDKN1C FNDC3B FNDC3B WEE2 WEE2 PSMD10 PSMD10 POLE4 POLE4 E2F1 E2F1 PSMF1 PSMF1 E2F4 E2F4 KXD1 KXD1 PPP2R1B PPP2R1B PSMD8 PSMD8 POLE POLE PSMC2 PSMC2 ORC5 ORC5 PSMA7 PSMA7 MCM10 MCM10 PSMD11 PSMD11 CDK6 CDK6 MEIOB MEIOB PSMB4 PSMB4 JAK2 JAK2 PSME3 PSME3 ORC2 ORC2 CREBZF CREBZF TFDP2 TFDP2 E2F5 E2F5 MCM7 MCM7 TM4SF19 TM4SF19 RBL2 RBL2 MCM8 MCM8 PSMB7 PSMB7 ORC6 ORC6 CDKN1A CDKN1A MYBL2 MYBL2 PSMA3 PSMA3 RELCH RELCH PSMD13 PSMD13 PSMC1 PSMC1 PSMD6 PSMD6 RPA3 RPA3 MNAT1 MNAT1 RPS27A RPS27A PSMD12 PSMD12 MCM9 MCM9 PSMD7 PSMD7 PSMC3 PSMC3 PPP4R1 PPP4R1 PSMB1 PSMB1 CDC45 CDC45 ENSTTRP00000014196 ENSTTRP00000014196 CDK2 CDK2 CDKN1B CDKN1B ABL1 ABL1 WEE1 WEE1 LOC101323349 LOC101323349 ENSTTRP00000014765 ENSTTRP00000014765 CCNH CCNH CDK3 CDK3 PPP2R2B PPP2R2B PSMD1 PSMD1 CDC25A CDC25A E2F2 E2F2 GMNN GMNN ORC1 ORC1 CKS1B CKS1B PTK6 PTK6 ORC4 ORC4 ENSTTRP00000015677 ENSTTRP00000015677 TESMIN TESMIN LYN LYN SKP1 SKP1 PPP2CA PPP2CA PSMD3 PSMD3 CDC6 CDC6 MCM2 MCM2 LOC101316193 LOC101316193 CCND1 CCND1 CUL1 CUL1 UBA52 UBA52 PPP2R2A PPP2R2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DBF4Protein DBF4 homolog A isoform X1. (675 aa)
PPP2CBProtein phosphatase 2 catalytic subunit beta. (285 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (86 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
FNBP4Formin-binding protein 4 isoform X2. (1015 aa)
PSMB6Proteasome subunit beta type-6. (238 aa)
KIAA2012LOW QUALITY PROTEIN: uncharacterized protein KIAA2012 homolog. (566 aa)
ENSTTRP00000000601annotation not available (515 aa)
PSMA4Proteasome subunit alpha type. (258 aa)
PSMC426S protease regulatory subunit 6B isoform X2; Belongs to the AAA ATPase family. (416 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (347 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X5. (557 aa)
PSMB5Proteasome subunit beta. (215 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
UBCpolyubiquitin-C. (457 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1067 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (411 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1147 aa)
CKS2CDC28 protein kinase regulatory subunit 2. (62 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
MCM6DNA helicase; Belongs to the MCM family. (820 aa)
MCM3DNA helicase; Belongs to the MCM family. (801 aa)
LIN37Protein lin-37 homolog isoform X1. (246 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (464 aa)
PSMC626S protease regulatory subunit 10B isoform X1; Belongs to the AAA ATPase family. (389 aa)
DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2. (629 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
RB1Retinoblastoma-associated protein. (922 aa)
PSMB8Proteasome subunit beta. (247 aa)
PSMB9Proteasome subunit beta. (219 aa)
LOC101323346Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (491 aa)
CDT1DNA replication factor Cdt1. (372 aa)
TFDP1Transcription factor. (410 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
LIN9Protein lin-9 homolog isoform X1. (580 aa)
POLA1DNA polymerase. (1467 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
CDC7Cell division cycle 7-related protein kinase. (572 aa)
LIN52Protein lin-52 homolog isoform X1. (105 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (294 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform X1. (504 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMC526S protease regulatory subunit 8 isoform X3; Belongs to the AAA ATPase family. (406 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (380 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (847 aa)
PSMB2Proteasome subunit beta. (248 aa)
MCM5DNA replication licensing factor MCM5-like. (734 aa)
RPA2Replication protein A 32 kDa subunit. (344 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
LIN54Protein lin-54 homolog isoform X2. (737 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2. (453 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (161 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (350 aa)
SKP2S-phase kinase-associated protein 2 isoform X2. (441 aa)
MCM4DNA helicase; Belongs to the MCM family. (692 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (254 aa)
PSME1Proteasome activator complex subunit 1. (248 aa)
PSME2Proteasome activator complex subunit 2. (248 aa)
PRR5LProline-rich protein 5-like isoform X3. (368 aa)
CABLES1CDK5 and ABL1 enzyme substrate 1. (351 aa)
ORC3Origin recognition complex subunit 3 isoform X3. (714 aa)
UBBpolyubiquitin-B. (229 aa)
E2F3Transcription factor E2F3. (334 aa)
PSMB10Proteasome 20S subunit beta 10. (273 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
CCND3Cyclin D3. (225 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (249 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X4. (1203 aa)
WEE2Wee1-like protein kinase. (569 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
POLE4LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 4. (116 aa)
E2F1Transcription factor E2F1 isoform X1. (437 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X1. (256 aa)
E2F4LOW QUALITY PROTEIN: transcription factor E2F4. (398 aa)
KXD1KxDL motif containing 1. (176 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (664 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2262 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
ORC5Origin recognition complex subunit 5 isoform X1. (376 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
MCM10Protein MCM10 homolog. (872 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (442 aa)
PSMB4Proteasome 20S subunit beta 4. (259 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PSME3Proteasome activator subunit 3. (268 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (496 aa)
CREBZFCREB/ATF bZIP transcription factor isoform X2. (353 aa)
TFDP2Transcription factor. (445 aa)
E2F5Transcription factor E2F5 isoform X2. (340 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
TM4SF19Transmembrane 4 L6 family member 19. (208 aa)
RBL2Retinoblastoma-like protein 2. (1140 aa)
MCM8DNA helicase MCM8 isoform X1; Belongs to the MCM family. (821 aa)
PSMB7Proteasome subunit beta. (277 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
MYBL2MYB proto-oncogene like 2. (692 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X3. (1211 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
PSMC126S protease regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6 isoform X1. (389 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X2. (455 aa)
MCM9DNA helicase MCM9 isoform X4; Belongs to the MCM family. (696 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7 isoform X2. (322 aa)
PSMC326S protease regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (433 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X5. (921 aa)
PSMB1Proteasome subunit beta. (239 aa)
CDC45Cell division control protein 45 homolog. (567 aa)
ENSTTRP00000014196annotation not available (422 aa)
CDK2Cyclin dependent kinase 2. (298 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (173 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
WEE1Wee1-like protein kinase. (646 aa)
LOC101323349LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 1-like. (437 aa)
ENSTTRP00000014765annotation not available (408 aa)
CCNHcyclin-H; Belongs to the cyclin family. (323 aa)
CDK3Cyclin dependent kinase 3. (304 aa)
PPP2R2BProtein phosphatase 2 regulatory subunit Bbeta. (509 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (949 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (523 aa)
E2F2Transcription factor E2F2 isoform X1. (433 aa)
GMNNGeminin. (210 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PTK6Tyrosine-protein kinase. (425 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ENSTTRP00000015677annotation not available (289 aa)
TESMINTesmin isoform X2. (470 aa)
LYNTyrosine-protein kinase. (491 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
MCM2Minichromosome maintenance complex component 2. (905 aa)
LOC101316193DNA polymerase alpha subunit B isoform X2. (597 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CUL1Cullin-1; Belongs to the cullin family. (767 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (505 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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