STRINGSTRING
ANAPC5 ANAPC5 PSMB6 PSMB6 KIAA2012 KIAA2012 ENSTTRP00000000601 ENSTTRP00000000601 RFC5 RFC5 PSMA4 PSMA4 PSMC4 PSMC4 PRIM2 PRIM2 POLE3 POLE3 RPA1 RPA1 PSMB5 PSMB5 CCNA2 CCNA2 GINS1 GINS1 UBC UBC ENSTTRP00000001764 ENSTTRP00000001764 RAD21 RAD21 STAG2 STAG2 ANAPC2 ANAPC2 PRIM1 PRIM1 FAM89B FAM89B POLD1 POLD1 UBE2S UBE2S UBE2E1 UBE2E1 TM7SF3 TM7SF3 CDK7 CDK7 ANAPC4 ANAPC4 PSMD9 PSMD9 CDC26 CDC26 CKS2 CKS2 GINS4 GINS4 PSMA1 PSMA1 MCM6 MCM6 MCM3 MCM3 CCNA1 CCNA1 PSMC6 PSMC6 RB1 RB1 PSMB8 PSMB8 RCBTB2 RCBTB2 PSMB9 PSMB9 CDT1 CDT1 CCNE2 CCNE2 ESCO1 ESCO1 ATAD5 ATAD5 ESCO2 ESCO2 POLA1 POLA1 CDC23 CDC23 PSMA2 PSMA2 POLD3 POLD3 POLD2 POLD2 PSMD14 PSMD14 PSMD5 PSMD5 PSMB3 PSMB3 PSMC5 PSMC5 PSMD4 PSMD4 PSMB2 PSMB2 PSME4 PSME4 MCM5 MCM5 POLE2 POLE2 WAPL WAPL SMC3 SMC3 PSMA6 PSMA6 TCERG1L TCERG1L CCNE1 CCNE1 SKP2 SKP2 MCM4 MCM4 CDK4 CDK4 GINS3 GINS3 PSME1 PSME1 PSME2 PSME2 LIG1 LIG1 RFC2 RFC2 FZR1 FZR1 CABLES1 CABLES1 ORC3 ORC3 UBB UBB UBE2D1 UBE2D1 PSMB10 PSMB10 CDC25B CDC25B PSMA5 PSMA5 CDKN1C CDKN1C ANAPC16 ANAPC16 WEE2 WEE2 PSMD10 PSMD10 POLE4 POLE4 PSMF1 PSMF1 STAG1 STAG1 KXD1 KXD1 PDS5B PDS5B PSMD8 PSMD8 POLE POLE PSMC2 PSMC2 ORC5 ORC5 ANAPC15 ANAPC15 PSMA7 PSMA7 PSMD11 PSMD11 FEN1 FEN1 RFC3 RFC3 MEIOB MEIOB PSMB4 PSMB4 SMC1A SMC1A PSME3 PSME3 ORC2 ORC2 CREBZF CREBZF RBX1 RBX1 ANAPC10 ANAPC10 PDS5A PDS5A ANAPC11 ANAPC11 MCM7 MCM7 TM4SF19 TM4SF19 MCM8 MCM8 RCBTB1 RCBTB1 PSMB7 PSMB7 ORC6 ORC6 DNA2 DNA2 CDKN1A CDKN1A PSMA3 PSMA3 PSMD13 PSMD13 CDC27 CDC27 PSMC1 PSMC1 PSMD6 PSMD6 RPA3 RPA3 MNAT1 MNAT1 RPS27A RPS27A PSMD12 PSMD12 MCM9 MCM9 PSMD7 PSMD7 PSMC3 PSMC3 RFC1 RFC1 PSMA8 PSMA8 PSMB1 PSMB1 CDK2 CDK2 CDKN1B CDKN1B ANAPC7 ANAPC7 WEE1 WEE1 PCNA PCNA CDC16 CDC16 CCNH CCNH CDK3 CDK3 UBE2C UBE2C GINS2 GINS2 PSMD1 PSMD1 CDC25A CDC25A GMNN GMNN ORC1 ORC1 CKS1B CKS1B PTK6 PTK6 ORC4 ORC4 ANAPC1 ANAPC1 RFC4 RFC4 SKP1 SKP1 PSMD3 PSMD3 CDC6 CDC6 MCM2 MCM2 CDCA5 CDCA5 LOC101316193 LOC101316193 CCND1 CCND1 CUL1 CUL1 UBA52 UBA52 PSMB11 PSMB11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANAPC5Anaphase-promoting complex subunit 5 isoform X1. (754 aa)
PSMB6Proteasome subunit beta type-6. (238 aa)
KIAA2012LOW QUALITY PROTEIN: uncharacterized protein KIAA2012 homolog. (566 aa)
ENSTTRP00000000601annotation not available (515 aa)
RFC5Replication factor C subunit 5. (341 aa)
PSMA4Proteasome subunit alpha type. (258 aa)
PSMC426S protease regulatory subunit 6B isoform X2; Belongs to the AAA ATPase family. (416 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (347 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
PSMB5Proteasome subunit beta. (215 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
GINS1DNA replication complex GINS protein PSF1 isoform X3. (196 aa)
UBCpolyubiquitin-C. (457 aa)
ENSTTRP00000001764annotation not available (98 aa)
RAD21Double-strand-break repair protein rad21 homolog isoform X1. (630 aa)
STAG2Cohesin subunit SA-2 isoform X1. (1268 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (816 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (411 aa)
FAM89BProtein FAM89B. (100 aa)
POLD1LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit. (1125 aa)
UBE2SUbiquitin conjugating enzyme E2 S. (222 aa)
UBE2E1Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
TM7SF3Transmembrane 7 superfamily member 3. (569 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa)
CDC26Anaphase-promoting complex subunit CDC26 isoform X2. (85 aa)
CKS2CDC28 protein kinase regulatory subunit 2. (62 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
MCM6DNA helicase; Belongs to the MCM family. (820 aa)
MCM3DNA helicase; Belongs to the MCM family. (801 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (464 aa)
PSMC626S protease regulatory subunit 10B isoform X1; Belongs to the AAA ATPase family. (389 aa)
RB1Retinoblastoma-associated protein. (922 aa)
PSMB8Proteasome subunit beta. (247 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (550 aa)
PSMB9Proteasome subunit beta. (219 aa)
CDT1DNA replication factor Cdt1. (372 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
ESCO1N-acetyltransferase ESCO1 isoform X1. (845 aa)
ATAD5ATPase family AAA domain-containing protein 5 isoform X1. (1830 aa)
ESCO2N-acetyltransferase ESCO2. (601 aa)
POLA1DNA polymerase. (1467 aa)
CDC23Cell division cycle protein 23 homolog. (597 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
POLD3DNA polymerase delta subunit 3 isoform X1. (465 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (294 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform X1. (504 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMC526S protease regulatory subunit 8 isoform X3; Belongs to the AAA ATPase family. (406 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (380 aa)
PSMB2Proteasome subunit beta. (248 aa)
PSME4Proteasome activator complex subunit 4 isoform X2. (1762 aa)
MCM5DNA replication licensing factor MCM5-like. (734 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
WAPLWings apart-like protein homolog isoform X1. (1270 aa)
SMC3Structural maintenance of chromosomes protein. (1215 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
TCERG1LTranscription elongation regulator 1 like. (521 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (350 aa)
SKP2S-phase kinase-associated protein 2 isoform X2. (441 aa)
MCM4DNA helicase; Belongs to the MCM family. (692 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (254 aa)
GINS3DNA replication complex GINS protein PSF3. (216 aa)
PSME1Proteasome activator complex subunit 1. (248 aa)
PSME2Proteasome activator complex subunit 2. (248 aa)
LIG1DNA ligase. (923 aa)
RFC2Replication factor C subunit 2. (316 aa)
FZR1Fizzy-related protein homolog. (494 aa)
CABLES1CDK5 and ABL1 enzyme substrate 1. (351 aa)
ORC3Origin recognition complex subunit 3 isoform X3. (714 aa)
UBBpolyubiquitin-B. (229 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
PSMB10Proteasome 20S subunit beta 10. (273 aa)
CDC25BCell division cycle 25B. (568 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (249 aa)
ANAPC16Anaphase-promoting complex subunit 16. (110 aa)
WEE2Wee1-like protein kinase. (569 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
POLE4LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 4. (116 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X1. (256 aa)
STAG1Cohesin subunit SA-1 isoform X1. (1258 aa)
KXD1KxDL motif containing 1. (176 aa)
PDS5BSister chromatid cohesion protein PDS5 homolog B. (1448 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2262 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
ORC5Origin recognition complex subunit 5 isoform X1. (376 aa)
ANAPC15Anaphase-promoting complex subunit 15 isoform X2. (120 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC3Replication factor C subunit 3 isoform X2. (355 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (442 aa)
PSMB4Proteasome 20S subunit beta 4. (259 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
PSME3Proteasome activator subunit 3. (268 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (496 aa)
CREBZFCREB/ATF bZIP transcription factor isoform X2. (353 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (82 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
PDS5ASister chromatid cohesion protein PDS5 homolog A isoform X1. (1338 aa)
ANAPC11Anaphase-promoting complex subunit 11. (193 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
TM4SF19Transmembrane 4 L6 family member 19. (208 aa)
MCM8DNA helicase MCM8 isoform X1; Belongs to the MCM family. (821 aa)
RCBTB1RCC1 and BTB domain-containing protein 1 isoform X2. (531 aa)
PSMB7Proteasome subunit beta. (277 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1059 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
CDC27Cell division cycle protein 27 homolog isoform X3. (824 aa)
PSMC126S protease regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6 isoform X1. (389 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X2. (455 aa)
MCM9DNA helicase MCM9 isoform X4; Belongs to the MCM family. (696 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7 isoform X2. (322 aa)
PSMC326S protease regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (433 aa)
RFC1Replication factor C subunit 1-like isoform X1. (1149 aa)
PSMA8Proteasome subunit alpha type. (221 aa)
PSMB1Proteasome subunit beta. (239 aa)
CDK2Cyclin dependent kinase 2. (298 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (173 aa)
ANAPC7LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7. (564 aa)
WEE1Wee1-like protein kinase. (646 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (187 aa)
CDC16Cell division cycle protein 16 homolog isoform X1. (620 aa)
CCNHcyclin-H; Belongs to the cyclin family. (323 aa)
CDK3Cyclin dependent kinase 3. (304 aa)
UBE2CUbiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (949 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (523 aa)
GMNNGeminin. (210 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PTK6Tyrosine-protein kinase. (425 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ANAPC1Anaphase-promoting complex subunit 1 isoform X1. (1943 aa)
RFC4Replication factor C subunit 4. (364 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
MCM2Minichromosome maintenance complex component 2. (905 aa)
CDCA5Cell division cycle associated 5. (307 aa)
LOC101316193DNA polymerase alpha subunit B isoform X2. (597 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CUL1Cullin-1; Belongs to the cullin family. (767 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
PSMB11Proteasome subunit beta. (259 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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