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| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (475 aa) |
| | LOC101330510 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PSMB6 | Proteasome subunit beta type-6. (238 aa) |
| | RFC5 | Replication factor C subunit 5. (341 aa) |
| | PSMA4 | Proteasome subunit alpha type. (258 aa) |
| | PSMC4 | 26S protease regulatory subunit 6B isoform X2; Belongs to the AAA ATPase family. (416 aa) |
| | YWHAQ | 14-3-3 protein theta; Belongs to the 14-3-3 family. (242 aa) |
| | CDK1 | Cyclin-dependent kinase 1 isoform X3; Belongs to the protein kinase superfamily. (301 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | PSMB5 | Proteasome subunit beta. (215 aa) |
| | UBC | polyubiquitin-C. (457 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80 isoform X1. (720 aa) |
| | RAD50 | DNA repair protein RAD50. (1267 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (683 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa) |
| | BABAM1 | BRISC and BRCA1-A complex member 1 isoform X1. (367 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1 isoform X1. (278 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (801 aa) |
| | PSMC6 | 26S protease regulatory subunit 10B isoform X1; Belongs to the AAA ATPase family. (389 aa) |
| | ANKRD11 | Ankyrin repeat domain-containing protein 11 isoform X5. (2622 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (450 aa) |
| | GTSE1 | G2 and S phase-expressed protein 1 isoform X2. (715 aa) |
| | PSMB8 | Proteasome subunit beta. (247 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2 isoform X1. (550 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | BRIP1 | Fanconi anemia group J protein isoform X1. (1232 aa) |
| | RMI2 | recQ-mediated genome instability protein 2. (77 aa) |
| | ABRAXAS1 | BRCA1-A complex subunit Abraxas isoform X1. (410 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101320102 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC101322350 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CCNB2 | G2/mitotic-specific cyclin-B2 isoform X1; Belongs to the cyclin family. (371 aa) |
| | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (240 aa) |
| | CDC25C | M-phase inducer phosphatase 3 isoform X2. (475 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169. (705 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase. (572 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component 1. (2046 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | DBF4 | Protein DBF4 homolog A isoform X1. (675 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (294 aa) |
| | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 isoform X1. (504 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor protein 1 isoform X1. (895 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (461 aa) |
| | PSMC5 | 26S protease regulatory subunit 8 isoform X3; Belongs to the AAA ATPase family. (406 aa) |
| | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 isoform X1. (380 aa) |
| | PSMB2 | Proteasome subunit beta. (248 aa) |
| | PSME4 | Proteasome activator complex subunit 4 isoform X2. (1762 aa) |
| | MCM5 | DNA replication licensing factor MCM5-like. (734 aa) |
| | ENSTTRP00000006970 | annotation not available (102 aa) |
| | YWHAB | 14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1 isoform X1. (773 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | BRCC3 | Lys-63-specific deubiquitinase BRCC36 isoform X1. (317 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (692 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (2032 aa) |
| | PSME1 | Proteasome activator complex subunit 1. (248 aa) |
| | PSME2 | Proteasome activator complex subunit 2. (248 aa) |
| | RFC2 | Replication factor C subunit 2. (316 aa) |
| | ORC3 | Origin recognition complex subunit 3 isoform X3. (714 aa) |
| | UBB | polyubiquitin-B. (229 aa) |
| | PSMB10 | Proteasome 20S subunit beta 10. (273 aa) |
| | WDR41 | WD repeat-containing protein 41 isoform X1. (459 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | RBBP8 | DNA endonuclease RBBP8 isoform X2. (846 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1210 aa) |
| | WEE2 | Wee1-like protein kinase. (569 aa) |
| | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa) |
| | ATR | Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2623 aa) |
| | TDRD3 | Tudor domain-containing protein 3 isoform X1. (651 aa) |
| | PSMF1 | Proteasome inhibitor PI31 subunit isoform X1. (256 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa) |
| | ENSTTRP00000009732 | annotation not available (544 aa) |
| | YWHAH | 14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | CCNB3 | Cyclin B3. (1237 aa) |
| | KXD1 | KxDL motif containing 1. (176 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8. (351 aa) |
| | PSMC2 | 26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa) |
| | ORC5 | Origin recognition complex subunit 5 isoform X1. (376 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | MCM10 | Protein MCM10 homolog. (872 aa) |
| | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11. (422 aa) |
| | RFC3 | Replication factor C subunit 3 isoform X2. (355 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform X1. (442 aa) |
| | PSMB4 | Proteasome 20S subunit beta 4. (259 aa) |
| | PSME3 | Proteasome activator subunit 3. (268 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa) |
| | ORC2 | Origin recognition complex subunit 2 isoform X1. (496 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2 isoform X2. (580 aa) |
| | WRN | Werner syndrome ATP-dependent helicase isoform X2. (1352 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa) |
| | BABAM2 | BRCA1-A complex subunit BRE. (411 aa) |
| | TM4SF19 | Transmembrane 4 L6 family member 19. (208 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1-like isoform X2. (1520 aa) |
| | MCM8 | DNA helicase MCM8 isoform X1; Belongs to the MCM family. (821 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1 isoform X2. (531 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (746 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (390 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1059 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (262 aa) |
| | LOC101330510-2 | Histone H2B type 1-L-like. (126 aa) |
| | LOC101320102-2 | Histone H4. (103 aa) |
| | LOC101329634 | Histone H4. (103 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101320102-3 | Histone H4. (103 aa) |
| | LOC101328760 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13. (376 aa) |
| | PSMC1 | 26S protease regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa) |
| | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 isoform X1. (389 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | NSD2 | Histone-lysine N-methyltransferase NSD2. (1357 aa) |
| | RPS27A | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | EXD2-2 | Exonuclease 3'-5' domain-containing protein 2. (124 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 isoform X2. (455 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (496 aa) |
| | MCM9 | DNA helicase MCM9 isoform X4; Belongs to the MCM family. (696 aa) |
| | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 isoform X2. (322 aa) |
| | PSMC3 | 26S protease regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (433 aa) |
| | EXO1 | Exonuclease 1 isoform X3. (835 aa) |
| | HERC2 | E3 ubiquitin-protein ligase HERC2 isoform X7. (4825 aa) |
| | PSMA8 | Proteasome subunit alpha type. (221 aa) |
| | PSMB1 | Proteasome subunit beta. (239 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma. (238 aa) |
| | CDC45 | Cell division control protein 45 homolog. (567 aa) |
| | CDK2 | Cyclin dependent kinase 2. (298 aa) |
| | CLSPN | Claspin. (1331 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (506 aa) |
| | ENSTTRP00000014547 | annotation not available (387 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101320102-4 | Histone H4. (103 aa) |
| | LOC101319223 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CDK3 | Cyclin dependent kinase 3. (304 aa) |
| | YWHAZ | 14-3-3 protein zeta/delta isoform X1; Belongs to the 14-3-3 family. (245 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (949 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa) |
| | TP53BP1 | Tumor suppressor p53-binding protein 1 isoform X1. (1972 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1409 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | YWHAE | 14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1. (499 aa) |
| | SFN | Stratifin. (248 aa) |
| | RMI1 | recQ-mediated genome instability protein 1 isoform X1. (626 aa) |
| | LOC101320102-5 | Histone H4. (103 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101320102-6 | Histone H4. (103 aa) |
| | LOC101328661 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101327496 | Histone H2B type 1-L-like isoform X1; Belongs to the histone H2B family. (125 aa) |
| | LOC101320102-7 | Histone H4. (103 aa) |
| | LOC101332610 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101320102-8 | Histone H4. (103 aa) |
| | ENSTTRP00000015893 | annotation not available (99 aa) |
| | LOC101324906 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101323719 | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | LOC101320102-9 | Histone H4. (103 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3. (534 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa) |
| | ENSTTRP00000016047 | annotation not available (460 aa) |
| | MCM2 | Minichromosome maintenance complex component 2. (905 aa) |
| | ATRIP | ATR-interacting protein isoform X1. (790 aa) |
| | UBA52 | ubiquitin-60S ribosomal protein L40. (128 aa) |
| | PSMB11 | Proteasome subunit beta. (259 aa) |
