STRINGSTRING
TGIF1 TGIF1 UBC UBC HDAC1 HDAC1 PPP1R15A PPP1R15A ENSTTRP00000001105 ENSTTRP00000001105 PMEPA1 PMEPA1 NCOR2 NCOR2 PARP1 PARP1 SKIL SKIL RBL1 RBL1 FOXH1 FOXH1 IRX4 IRX4 ENSTTRP00000001877 ENSTTRP00000001877 NCOR1 NCOR1 LTBP3 LTBP3 MEIS3 MEIS3 BMP2 BMP2 CCNT1 CCNT1 SMAD2 SMAD2 TRIM33 TRIM33 ACVR1B ACVR1B ATP1B4 ATP1B4 ZCCHC4 ZCCHC4 SMURF1 SMURF1 SMAD3 SMAD3 BAMBI BAMBI NEDD4L NEDD4L WWTR1 WWTR1 STRAP STRAP FKBP1A FKBP1A JUNB JUNB INHBA INHBA LOC101324780 LOC101324780 ITGA8 ITGA8 STUB1 STUB1 SMAD7 SMAD7 TGFBR2 TGFBR2 TFDP1 TFDP1 CCNC CCNC ACVRL1 ACVRL1 BMPR2 BMPR2 RNF111 RNF111 ACVR2B ACVR2B CBL CBL MAPK3 MAPK3 CDK19 CDK19 CHRDL2 CHRDL2 TGIF2 TGIF2 IRX2 IRX2 DAND5 DAND5 LTBP1 LTBP1 MTMR4 MTMR4 LTBP4 LTBP4 LDLRAD4 LDLRAD4 ACVR1 ACVR1 FURIN FURIN SMAD9 SMAD9 CER1 CER1 SMAD1 SMAD1 BMPR1A BMPR1A NEDD8 NEDD8 ZFYVE16 ZFYVE16 SMURF2 SMURF2 MEN1 MEN1 PARD3 PARD3 PPM1A PPM1A UBB UBB F11R F11R PARD6A PARD6A UBE2D1 UBE2D1 SNW1 SNW1 SP1 SP1 AMHR2 AMHR2 SKI SKI ITGB1 ITGB1 ENSTTRP00000009655 ENSTTRP00000009655 SMAD6 SMAD6 E2F4 E2F4 KXD1 KXD1 ITGB6 ITGB6 CGN CGN CCNQ CCNQ SMAD4 SMAD4 PRKCZ PRKCZ TFDP2 TFDP2 E2F5 E2F5 FST FST ITGAV ITGAV CHRDL1 CHRDL1 TGFB1 TGFB1 LTBP2 LTBP2 GDF2 GDF2 ITGB3 ITGB3 BMP10 BMP10 TGFB2 TGFB2 TGFBR1 TGFBR1 USP9X USP9X RPS27A RPS27A INHBB INHBB PCSK4 PCSK4 PARD3B PARD3B MEIS2 MEIS2 CCNT2 CCNT2 ITGB5 ITGB5 BMPR1B BMPR1B ITGB8 ITGB8 TGFB3 TGFB3 FBN1 FBN1 ACVR1C ACVR1C ENSTTRP00000014801 ENSTTRP00000014801 ZFYVE9 ZFYVE9 MKX MKX CDK8 CDK8 SMAD5 SMAD5 ACVR2A ACVR2A CDK9 CDK9 FSTL1 FSTL1 MAPK1 MAPK1 CCNK CCNK RHOA RHOA UBA52 UBA52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGIF1Homeobox protein TGIF1 isoform X3. (363 aa)
UBCpolyubiquitin-C. (457 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (563 aa)
ENSTTRP00000001105annotation not available (442 aa)
PMEPA1Protein TMEPAI. (289 aa)
NCOR2Nuclear receptor corepressor 2-like. (2522 aa)
PARP1Poly [ADP-ribose] polymerase 1. (1011 aa)
SKILSki-like protein isoform X1. (681 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1067 aa)
FOXH1Forkhead box H1. (360 aa)
IRX4Iroquois-class homeodomain protein IRX-4. (521 aa)
ENSTTRP00000001877annotation not available (160 aa)
NCOR1Nuclear receptor corepressor 1 isoform X5. (2434 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1301 aa)
MEIS3Meis homeobox 3. (421 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
CCNT1cyclin-T1 isoform X3; Belongs to the cyclin family. (726 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TRIM33E3 ubiquitin-protein ligase TRIM33 isoform X3. (1127 aa)
ACVR1BActivin A receptor type 1B. (504 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
ZCCHC4Zinc finger CCHC domain-containing protein 4 isoform X2. (513 aa)
SMURF1E3 ubiquitin-protein ligase. (738 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (234 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like isoform X3. (992 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
STRAPSerine-threonine kinase receptor-associated protein isoform X1. (350 aa)
FKBP1APeptidylprolyl isomerase. (152 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
INHBAInhibin beta A chain. (421 aa)
LOC101324780Rho guanine nucleotide exchange factor 18-like. (1159 aa)
ITGA8Integrin alpha-8; Belongs to the integrin alpha chain family. (1060 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
SMAD7Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (579 aa)
TFDP1Transcription factor. (410 aa)
CCNCcyclin-C isoform X1; Belongs to the cyclin family. (302 aa)
ACVRL1Activin A receptor like type 1. (497 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X11. (993 aa)
ACVR2BActivin A receptor type 2B. (511 aa)
CBLE3 ubiquitin-protein ligase CBL. (883 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
CDK19Cyclin-dependent kinase 19 isoform X2. (497 aa)
CHRDL2Chordin like 2. (452 aa)
TGIF2Homeobox protein TGIF2. (196 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (471 aa)
DAND5DAN domain BMP antagonist family member 5. (182 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1599 aa)
MTMR4Myotubularin-related protein 4. (1183 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1624 aa)
LDLRAD4LOW QUALITY PROTEIN: low-density lipoprotein receptor class A domain-containing protein 4. (324 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
FURINFurin; Belongs to the peptidase S8 family. (792 aa)
SMAD9Mothers against decapentaplegic homolog. (466 aa)
CER1Cerberus. (271 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
NEDD8NEDD8 isoform X2. (67 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16 isoform X2. (1545 aa)
SMURF2E3 ubiquitin-protein ligase. (648 aa)
MEN1Menin 1. (615 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1281 aa)
PPM1AProtein phosphatase 1A. (382 aa)
UBBpolyubiquitin-B. (229 aa)
F11RJunctional adhesion molecule A isoform X1. (298 aa)
PARD6APar-6 family cell polarity regulator alpha. (339 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
SNW1SNW domain-containing protein 1. (536 aa)
SP1Transcription factor Sp1. (784 aa)
AMHR2anti-Mullerian hormone receptor type 2. (576 aa)
SKISki oncogene. (633 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (786 aa)
ENSTTRP00000009655annotation not available (318 aa)
SMAD6SMAD family member 6. (492 aa)
E2F4LOW QUALITY PROTEIN: transcription factor E2F4. (398 aa)
KXD1KxDL motif containing 1. (176 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CGNCingulin. (1194 aa)
CCNQCyclin-related protein FAM58A. (266 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
PRKCZProtein kinase C zeta. (592 aa)
TFDP2Transcription factor. (445 aa)
E2F5Transcription factor E2F5 isoform X2. (340 aa)
FSTFollistatin isoform X2. (343 aa)
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1095 aa)
CHRDL1Chordin-like protein 1 isoform X3. (457 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1814 aa)
GDF2Growth/differentiation factor 2. (431 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X2; Belongs to the peptidase C19 family. (2527 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
INHBBInhibin beta B chain. (407 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (758 aa)
PARD3BPartitioning defective 3 homolog B. (1202 aa)
MEIS2Homeobox protein Meis2 isoform X1. (345 aa)
CCNT2cyclin-T2 isoform X4; Belongs to the cyclin family. (733 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (782 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (765 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
FBN1Fibrillin-1. (2826 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
ENSTTRP00000014801annotation not available (387 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1422 aa)
MKXHomeobox protein Mohawk. (351 aa)
CDK8Cyclin-dependent kinase 8 isoform X6; Belongs to the protein kinase superfamily. (437 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
CDK9Cyclin-dependent kinase 9 isoform X1; Belongs to the protein kinase superfamily. (487 aa)
FSTL1Follistatin-related protein 1. (306 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
CCNKcyclin-K; Belongs to the cyclin family. (598 aa)
RHOATransforming protein RhoA. (193 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.