(32 nodes) (2022) Cochlear Development; New Tools and Approaches. network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (407 aa)
	NPY	Pro-neuropeptide Y isoform X2. (97 aa)
	LGR5	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1. (890 aa)
	NEUROD2	Neuronal differentiation 2. (382 aa)
	IRX2	Iroquois-class homeodomain protein IRX-2. (471 aa)
	CALB2	Calretinin. (272 aa)
	SOX2	Transcription factor SOX-2. (314 aa)
	FGFR1	Fibroblast growth factor receptor 1. (822 aa)
	NRCAM	Neuronal cell adhesion molecule isoform X1. (1215 aa)
	BACH2	Transcription regulator protein BACH2. (838 aa)
	LIN28B	Protein lin-28 homolog B isoform X3. (275 aa)
	FGF8	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (173 aa)
	CRABP1	Cellular retinoic acid binding protein 1. (137 aa)
	ZBTB8B	LOW QUALITY PROTEIN: zinc finger and BTB domain-containing protein 8B. (462 aa)
	MYO6	Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1283 aa)
	INHBA	Inhibin beta A chain. (421 aa)
	BHLHE40	Class E basic helix-loop-helix protein 40. (360 aa)
	IGFBP1	Insulin-like growth factor-binding protein 1. (230 aa)
	NHLH1	Helix-loop-helix protein 1. (133 aa)
	SLC17A8	Vesicular glutamate transporter 3. (585 aa)
	POU4F3	POU domain protein. (338 aa)
	TMC1	Transmembrane channel-like protein. (755 aa)
	BARHL1	barH-like 1 homeobox protein. (324 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FST	Follistatin isoform X2. (343 aa)
	FGFR1-2	Fibroblast growth factor receptor 1. (692 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	SLC26A5	Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (723 aa)
	RBP4	Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (199 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARHL1	POU4F3	ENSTTRP00000013359	ENSTTRP00000000884	barH-like 1 homeobox protein.	POU domain protein.	0.533
BMP4	FGF20	ENSTTRP00000008787	ENSTTRP00000011907	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.600
BMP4	FGF8	ENSTTRP00000008787	ENSTTRP00000014158	Bone morphogenetic protein 4.	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	0.670
BMP4	FGFR1	ENSTTRP00000008787	ENSTTRP00000004280	Bone morphogenetic protein 4.	Fibroblast growth factor receptor 1.	0.453
BMP4	FST	ENSTTRP00000008787	ENSTTRP00000011717	Bone morphogenetic protein 4.	Follistatin isoform X2.	0.765
BMP4	ISL1	ENSTTRP00000008787	ENSTTRP00000010273	Bone morphogenetic protein 4.	Insulin gene enhancer protein ISL-1.	0.550
BMP4	LGR5	ENSTTRP00000008787	ENSTTRP00000006933	Bone morphogenetic protein 4.	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1.	0.414
BMP4	LIN28B	ENSTTRP00000008787	ENSTTRP00000014136	Bone morphogenetic protein 4.	Protein lin-28 homolog B isoform X3.	0.420
BMP4	SOX2	ENSTTRP00000008787	ENSTTRP00000004572	Bone morphogenetic protein 4.	Transcription factor SOX-2.	0.715
BMP4	TGFBR1	ENSTTRP00000008787	ENSTTRP00000012962	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.835
CALB2	ISL1	ENSTTRP00000005792	ENSTTRP00000010273	Calretinin.	Insulin gene enhancer protein ISL-1.	0.455
CALB2	MYO6	ENSTTRP00000005792	ENSTTRP00000015135	Calretinin.	Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.489
CALB2	NEUROD2	ENSTTRP00000005792	ENSTTRP00000006822	Calretinin.	Neuronal differentiation 2.	0.403
CALB2	NPY	ENSTTRP00000005792	ENSTTRP00000007125	Calretinin.	Pro-neuropeptide Y isoform X2.	0.668
DLL1	LGR5	ENSTTRP00000013215	ENSTTRP00000006933	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1.	0.599
DLL1	MYO6	ENSTTRP00000013215	ENSTTRP00000015135	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.511
FGF20	BMP4	ENSTTRP00000011907	ENSTTRP00000008787	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.600
FGF20	FGF8	ENSTTRP00000011907	ENSTTRP00000014158	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family.	0.468
FGF20	FGFR1	ENSTTRP00000011907	ENSTTRP00000004280	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 1.	0.988
FGF20	FGFR1-2	ENSTTRP00000011907	ENSTTRP00000010371	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 1.	0.973