(34 nodes) Transforming growth factor-beta (TGF-beta) family network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
	GDF2	Growth/differentiation factor 2. (431 aa)
	BMP10	Bone morphogenetic protein 10. (423 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
	MSTN	Growth/differentiation factor 8. (375 aa)
	INHBB	Inhibin beta B chain. (407 aa)
	LOC101327238	Left-right determination factor. (201 aa)
	GDF9	Growth/differentiation factor 9 isoform X1. (454 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
	BMP7	Bone morphogenetic protein 7 isoform X2. (431 aa)
	BMP6	Bone morphogenetic protein 6. (304 aa)
	GDF5	Growth/differentiation factor 5. (489 aa)
	GDNF	Glial cell line-derived neurotrophic factor isoform X2. (211 aa)
	GDF3	Growth/differentiation factor 3. (364 aa)
	INHBE	Inhibin subunit beta E. (351 aa)
	BMP2	Bone morphogenetic protein 2. (388 aa)
	NODAL	Nodal homolog. (348 aa)
	INHBA	Inhibin beta A chain. (421 aa)
	BMP3	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
	GDF15	Growth differentiation factor 15. (308 aa)
	BMP5	Bone morphogenetic protein 5 isoform X2. (454 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	BMP15	Bone morphogenetic protein 15. (393 aa)
	NRTN	Neurturin. (197 aa)
	GDF11	Growth differentiation factor 11. (313 aa)
	ENSTTRP00000009655	annotation not available (318 aa)
	PSPN	Persephin. (153 aa)
	LOC101325454	Bone morphogenetic protein 8B. (241 aa)
	GDF1	Embryonic growth/differentiation factor 1. (370 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
	GDF6	Growth/differentiation factor 6. (458 aa)
	ENSTTRP00000011729	annotation not available (367 aa)
	TGFB1	Transforming growth factor beta 1. (338 aa)
	INHBC	Inhibin beta C chain. (247 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	BMP2	ENSTTRP00000012877	ENSTTRP00000002383	Bone morphogenetic protein 10.	Bone morphogenetic protein 2.	0.417
BMP10	BMP4	ENSTTRP00000012877	ENSTTRP00000008787	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.630
BMP10	BMP5	ENSTTRP00000012877	ENSTTRP00000005374	Bone morphogenetic protein 10.	Bone morphogenetic protein 5 isoform X2.	0.653
BMP10	BMP7	ENSTTRP00000012877	ENSTTRP00000014836	Bone morphogenetic protein 10.	Bone morphogenetic protein 7 isoform X2.	0.423
BMP10	GDF15	ENSTTRP00000012877	ENSTTRP00000004094	Bone morphogenetic protein 10.	Growth differentiation factor 15.	0.414
BMP10	GDF2	ENSTTRP00000012877	ENSTTRP00000012735	Bone morphogenetic protein 10.	Growth/differentiation factor 2.	0.946
BMP10	GDF5	ENSTTRP00000012877	ENSTTRP00000016136	Bone morphogenetic protein 10.	Growth/differentiation factor 5.	0.406
BMP10	MSTN	ENSTTRP00000012877	ENSTTRP00000013154	Bone morphogenetic protein 10.	Growth/differentiation factor 8.	0.418
BMP15	ENSTTRP00000009655	ENSTTRP00000008864	ENSTTRP00000009655	Bone morphogenetic protein 15.	annotation not available	0.821
BMP15	GDF9	ENSTTRP00000008864	ENSTTRP00000013964	Bone morphogenetic protein 15.	Growth/differentiation factor 9 isoform X1.	0.852
BMP15	INHA	ENSTTRP00000008864	ENSTTRP00000011103	Bone morphogenetic protein 15.	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family.	0.605
BMP2	BMP10	ENSTTRP00000002383	ENSTTRP00000012877	Bone morphogenetic protein 2.	Bone morphogenetic protein 10.	0.417
BMP2	BMP4	ENSTTRP00000002383	ENSTTRP00000008787	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.899
BMP2	BMP5	ENSTTRP00000002383	ENSTTRP00000005374	Bone morphogenetic protein 2.	Bone morphogenetic protein 5 isoform X2.	0.616
BMP2	BMP6	ENSTTRP00000002383	ENSTTRP00000015103	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.938
BMP2	BMP7	ENSTTRP00000002383	ENSTTRP00000014836	Bone morphogenetic protein 2.	Bone morphogenetic protein 7 isoform X2.	0.719
BMP2	GDF5	ENSTTRP00000002383	ENSTTRP00000016136	Bone morphogenetic protein 2.	Growth/differentiation factor 5.	0.543
BMP2	GDF6	ENSTTRP00000002383	ENSTTRP00000011723	Bone morphogenetic protein 2.	Growth/differentiation factor 6.	0.435
BMP2	LOC101325454	ENSTTRP00000002383	ENSTTRP00000010942	Bone morphogenetic protein 2.	Bone morphogenetic protein 8B.	0.571
BMP2	TGFB1	ENSTTRP00000002383	ENSTTRP00000012180	Bone morphogenetic protein 2.	Transforming growth factor beta 1.	0.504