73 items (Tursiops truncatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RFC5	Replication factor C subunit 5. (341 aa)
	TOR3A	torsin-3A isoform X1. (400 aa)
	LOC101316193	DNA polymerase alpha subunit B isoform X2. (597 aa)
	MCMDC2	MCM domain-containing protein 2. (590 aa)
	MCM2	Minichromosome maintenance complex component 2. (905 aa)
	CPNE8	Copine-8. (564 aa)
	RNASEH2C	Ribonuclease H2 subunit C. (164 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	EXOC8	Exocyst complex component 8. (688 aa)
	TOR2A	Torsin. (321 aa)
	GEN1	Flap endonuclease GEN homolog 1. (907 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (187 aa)
	TOR4A	torsin-4A. (416 aa)
	SASS6	SAS-6 centriolar assembly protein. (631 aa)
	RFC1	Replication factor C subunit 1-like isoform X1. (1149 aa)
	MCM9	DNA helicase MCM9 isoform X4; Belongs to the MCM family. (696 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1584 aa)
	PARP9	Poly [ADP-ribose] polymerase 9. (845 aa)
	FAM162A	Protein FAM162A. (141 aa)
	DNA2	DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1059 aa)
	CPNE2	Copine-2. (512 aa)
	TM4SF19	Transmembrane 4 L6 family member 19. (208 aa)
	MACROD2	O-acetyl-ADP-ribose deacetylase MACROD2-like. (424 aa)
	GTF3C6	General transcription factor 3C polypeptide 6. (123 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (129 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein isoform X1. (442 aa)
	RFC3	Replication factor C subunit 3 isoform X2. (355 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	FAM162B	Family with sequence similarity 162 member B. (130 aa)
	RNASEH2B	Ribonuclease H2 subunit B isoform X2. (308 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2262 aa)
	CPNE4	Copine-4. (557 aa)
	MACROD1	O-acetyl-ADP-ribose deacetylase MACROD1. (259 aa)
	C16orf70	UPF0183 protein C16orf70 homolog isoform X1. (495 aa)
	POLE4	LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 4. (116 aa)
	SSBP1	Single-stranded DNA-binding protein, mitochondrial isoform X2. (148 aa)
	CPNE9	Copine-9 isoform X2. (553 aa)
	RFC2	Replication factor C subunit 2. (316 aa)
	LIG1	DNA ligase. (923 aa)
	CABP5	Calcium-binding protein 1 isoform X2. (173 aa)
	CPNE6	Copine-6. (557 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (692 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	RPA2	Replication protein A 32 kDa subunit. (344 aa)
	MCM5	DNA replication licensing factor MCM5-like. (734 aa)
	TOR1A	torsin-1A isoform X2. (250 aa)
	TOR1B	torsin-1B. (335 aa)
	POLD2	DNA polymerase delta subunit 2. (469 aa)
	POLD3	DNA polymerase delta subunit 3 isoform X1. (465 aa)
	POLA1	DNA polymerase. (1467 aa)
	ATAD5	ATPase family AAA domain-containing protein 5 isoform X1. (1830 aa)
	ENSTTRP00000004121	annotation not available (372 aa)
	PRKRIP1	PRKR-interacting protein 1. (182 aa)
	WRNIP1	ATPase WRNIP1 isoform X2. (391 aa)
	GDAP2	Ganglioside-induced differentiation-associated protein 2 isoform X1. (497 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (801 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (820 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (213 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
	RAD17	Cell cycle checkpoint protein RAD17. (683 aa)
	CHRAC1	Chromatin accessibility complex protein 1. (132 aa)
	POLD1	LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit. (1125 aa)
	CPNE3	Copine-3 isoform X1. (538 aa)
	CPNE5	Copine-5 isoform X2. (588 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (411 aa)
	ENSTTRP00000001764	annotation not available (98 aa)
	YJU2	Coiled-coil domain-containing protein 94. (310 aa)
	RNASEH1	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	PRIM2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (347 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	DNA2	ENSTTRP00000004668	ENSTTRP00000012641	ATPase family AAA domain-containing protein 5 isoform X1.	DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1.	0.896
ATAD5	FEN1	ENSTTRP00000004668	ENSTTRP00000010655	ATPase family AAA domain-containing protein 5 isoform X1.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.924
ATAD5	GEN1	ENSTTRP00000004668	ENSTTRP00000015081	ATPase family AAA domain-containing protein 5 isoform X1.	Flap endonuclease GEN homolog 1.	0.711
ATAD5	LIG1	ENSTTRP00000004668	ENSTTRP00000008300	ATPase family AAA domain-containing protein 5 isoform X1.	DNA ligase.	0.809
ATAD5	LOC101316193	ENSTTRP00000004668	ENSTTRP00000016355	ATPase family AAA domain-containing protein 5 isoform X1.	DNA polymerase alpha subunit B isoform X2.	0.852
ATAD5	MCM2	ENSTTRP00000004668	ENSTTRP00000016215	ATPase family AAA domain-containing protein 5 isoform X1.	Minichromosome maintenance complex component 2.	0.895
ATAD5	MCM3	ENSTTRP00000004668	ENSTTRP00000003488	ATPase family AAA domain-containing protein 5 isoform X1.	DNA helicase; Belongs to the MCM family.	0.495
ATAD5	MCM4	ENSTTRP00000004668	ENSTTRP00000007880	ATPase family AAA domain-containing protein 5 isoform X1.	DNA helicase; Belongs to the MCM family.	0.753
ATAD5	MCM5	ENSTTRP00000004668	ENSTTRP00000006946	ATPase family AAA domain-containing protein 5 isoform X1.	DNA replication licensing factor MCM5-like.	0.523
ATAD5	MCM6	ENSTTRP00000004668	ENSTTRP00000003455	ATPase family AAA domain-containing protein 5 isoform X1.	DNA helicase; Belongs to the MCM family.	0.689
ATAD5	MCM7	ENSTTRP00000004668	ENSTTRP00000011680	ATPase family AAA domain-containing protein 5 isoform X1.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.696
ATAD5	MCM9	ENSTTRP00000004668	ENSTTRP00000013245	ATPase family AAA domain-containing protein 5 isoform X1.	DNA helicase MCM9 isoform X4; Belongs to the MCM family.	0.499
ATAD5	MEIOB	ENSTTRP00000004668	ENSTTRP00000010799	ATPase family AAA domain-containing protein 5 isoform X1.	Meiosis-specific with OB domain-containing protein isoform X1.	0.776
ATAD5	PCNA	ENSTTRP00000004668	ENSTTRP00000014564	ATPase family AAA domain-containing protein 5 isoform X1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.970
ATAD5	POLA1	ENSTTRP00000004668	ENSTTRP00000004988	ATPase family AAA domain-containing protein 5 isoform X1.	DNA polymerase.	0.843
ATAD5	POLD1	ENSTTRP00000004668	ENSTTRP00000002267	ATPase family AAA domain-containing protein 5 isoform X1.	LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit.	0.785
ATAD5	POLD2	ENSTTRP00000004668	ENSTTRP00000005704	ATPase family AAA domain-containing protein 5 isoform X1.	DNA polymerase delta subunit 2.	0.640
ATAD5	POLD3	ENSTTRP00000004668	ENSTTRP00000005442	ATPase family AAA domain-containing protein 5 isoform X1.	DNA polymerase delta subunit 3 isoform X1.	0.667
ATAD5	POLE	ENSTTRP00000004668	ENSTTRP00000010089	ATPase family AAA domain-containing protein 5 isoform X1.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.853
ATAD5	POLE2	ENSTTRP00000004668	ENSTTRP00000007250	ATPase family AAA domain-containing protein 5 isoform X1.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.797