STRINGSTRING
CACNA1D CACNA1D PLCB2 PLCB2 MYH3 MYH3 LOC101332449 LOC101332449 VDAC2 VDAC2 ATF2 ATF2 ADCY5 ADCY5 MYLK MYLK GUCY1A1 GUCY1A1 GUCY1B1 GUCY1B1 AKT2 AKT2 NOS3 NOS3 PPP3CB PPP3CB SLC25A5 SLC25A5 MEF2D MEF2D MYL9 MYL9 EDNRB EDNRB GNAI3 GNAI3 TMIGD3 TMIGD3 ATP1A2 ATP1A2 ATP1A4 ATP1A4 TRPC6 TRPC6 KCNU1 KCNU1 KCNMB1 KCNMB1 KCNMA1 KCNMA1 SLC8A2 SLC8A2 EDNRA EDNRA ADCY9 ADCY9 PPP3CA PPP3CA PDE5A PDE5A ATP1B4 ATP1B4 PDE2A PDE2A ENSTTRP00000002833 ENSTTRP00000002833 CACNA1C CACNA1C PIK3CG PIK3CG CALM3 CALM3 CNGA1 CNGA1 PRKG1 PRKG1 BDKRB2 BDKRB2 PDE3B PDE3B ITPR2 ITPR2 GNA12 GNA12 MYLK4 MYLK4 MRVI1 MRVI1 MEF2C MEF2C PRKG2 PRKG2 ADCY2 ADCY2 ATP2B2 ATP2B2 ADRB1 ADRB1 SLC25A4 SLC25A4 ADRA1A ADRA1A KCNMB4 KCNMB4 CREB3L2 CREB3L2 MAPK3 MAPK3 ATP1B1 ATP1B1 PPIF PPIF ATP2A3 ATP2A3 ATF6B ATF6B ENSTTRP00000005859 ENSTTRP00000005859 KCNMB2 KCNMB2 GNAI1 GNAI1 PIK3R6 PIK3R6 PIK3R5 PIK3R5 PDE3A PDE3A ENSTTRP00000006413 ENSTTRP00000006413 ATP2B1 ATP2B1 ITPR3 ITPR3 ADRA2A ADRA2A PTK7 PTK7 SRF SRF MEF2B MEF2B GNAI2 GNAI2 NFATC2 NFATC2 ATP2A1 ATP2A1 MYLK2 MYLK2 PPP1CB PPP1CB ENSTTRP00000007871 ENSTTRP00000007871 VASP VASP ADRB2 ADRB2 CNGB1 CNGB1 MYH8 MYH8 ADCY4 ADCY4 NFATC4 NFATC4 GNAQ GNAQ GTF2IRD1 GTF2IRD1 ENSTTRP00000008430 ENSTTRP00000008430 INSR INSR NPPC NPPC RGS2 RGS2 GNA13 GNA13 AGTR1 AGTR1 ADORA1 ADORA1 VDAC3 VDAC3 PLCB1 PLCB1 ADRA1D ADRA1D CREB3L3 CREB3L3 MAP2K1 MAP2K1 ATP1B2 ATP1B2 PLCB3 PLCB3 BAD BAD SLC8A1 SLC8A1 PPP1R12A PPP1R12A MYH6 MYH6 MYH7 MYH7 LOC101315484 LOC101315484 CREB3L4 CREB3L4 CALML6 CALML6 ADCY6 ADCY6 AKT3 AKT3 NPPA NPPA NPPB NPPB ATP1A1 ATP1A1 ATP2B3 ATP2B3 PRKCE PRKCE CREB3 CREB3 NPR2 NPR2 GATA4 GATA4 CALM2 CALM2 ATP1B3 ATP1B3 MYH15 MYH15 GNA11 GNA11 PPP3CC PPP3CC SLC25A31 SLC25A31 ADRA1B ADRA1B ROCK2 ROCK2 PPP1CA PPP1CA MYLK3 MYLK3 ADCY1 ADCY1 ADCY7 ADCY7 ADCY8 ADCY8 CALM1 CALM1 OPRD1 OPRD1 GUCY1A2 GUCY1A2 CACNA1S CACNA1S PLCB4 PLCB4 PLN PLN KCNMB3 KCNMB3 AKT1 AKT1 ITPR1 ITPR1 GTF2I GTF2I ENSTTRP00000013721 ENSTTRP00000013721 ATF4 ATF4 NFATC3 NFATC3 ATP2A2 ATP2A2 NPR1 NPR1 SLC8A3 SLC8A3 PPP1CC PPP1CC PTRHD1 PTRHD1 ADCY3 ADCY3 ROCK1 ROCK1 CREB5 CREB5 SLC25A6 SLC25A6 ENSTTRP00000014640 ENSTTRP00000014640 CREB1 CREB1 MYH1 MYH1 LOC109548408 LOC109548408 MEF2A MEF2A ENSTTRP00000015063 ENSTTRP00000015063 CALML4 CALML4 ATP2B4 ATP2B4 CREB3L1 CREB3L1 NFATC1 NFATC1 MAPK1 MAPK1 KNG1 KNG1 VDAC1 VDAC1 CACNA1F CACNA1F KCNJ8 KCNJ8 RHOA RHOA ENSTTRP00000016529 ENSTTRP00000016529
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
MYH3Myosin-3 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
LOC101332449Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (319 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
MYLKMyosin light chain kinase. (1911 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (684 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (610 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
NOS3Nitric oxide synthase 3. (1197 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (294 aa)
MEF2DMyocyte enhancer factor 2D. (494 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
EDNRBEndothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (530 aa)
GNAI3G protein subunit alpha i3. (354 aa)
TMIGD3LOW QUALITY PROTEIN: transmembrane and immunoglobulin domain containing 3. (347 aa)
ATP1A2ATPase Na+/K+ transporting subunit alpha 2. (1020 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1009 aa)
TRPC6Short transient receptor potential channel 6; Belongs to the transient receptor (TC 1.A.4) family. (930 aa)
KCNU1Potassium channel subfamily U member 1. (956 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X1. (1173 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
PPP3CASerine/threonine-protein phosphatase. (560 aa)
PDE5APhosphodiesterase. (865 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
PDE2APhosphodiesterase. (936 aa)
ENSTTRP00000002833annotation not available (131 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha-1C-like. (2195 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
CALM3Calmodulin 3. (148 aa)
CNGA1LOW QUALITY PROTEIN: cGMP-gated cation channel alpha-1. (692 aa)
PRKG1cGMP-dependent protein kinase 1; Belongs to the protein kinase superfamily. (686 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
PDE3BPhosphodiesterase. (1045 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (382 aa)
MYLK4Myosin light chain kinase family member 4. (388 aa)
MRVI1Murine retrovirus integration site 1 homolog. (885 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ATP2B2ATPase plasma membrane Ca2+ transporting 2. (1243 aa)
ADRB1Beta-1 adrenergic receptor. (467 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ADRA1Aalpha-1A adrenergic receptor. (423 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (206 aa)
CREB3L2LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (284 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (142 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1060 aa)
ATF6BActivating transcription factor 6 beta. (671 aa)
ENSTTRP00000005859annotation not available (334 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (836 aa)
PDE3APhosphodiesterase. (1131 aa)
ENSTTRP00000006413annotation not available (364 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1217 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3-like. (2669 aa)
ADRA2Aalpha-2A adrenergic receptor. (448 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
SRFSerum response factor isoform X2. (509 aa)
MEF2BMyocyte-specific enhancer factor 2B. (346 aa)
GNAI2G protein subunit alpha i2. (351 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X2. (919 aa)
ATP2A1Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1050 aa)
MYLK2Myosin light chain kinase 2. (597 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
ENSTTRP00000007871annotation not available (1012 aa)
VASPVasodilator-stimulated phosphoprotein. (406 aa)
ADRB2Beta-2 adrenergic receptor. (418 aa)
CNGB1Cyclic nucleotide-gated cation channel beta-1. (1120 aa)
MYH8Myosin-8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1855 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
NFATC4Nuclear factor of activated T cells 4. (746 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
GTF2IRD1General transcription factor II-I repeat domain-containing protein 1-like isoform X1. (927 aa)
ENSTTRP00000008430annotation not available (252 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
NPPCNatriuretic peptide C. (126 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (282 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (212 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (283 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
ADRA1Dalpha-1D adrenergic receptor. (569 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (455 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
ATP1B2ATPase Na+/K+ transporting subunit beta 2. (290 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
BADBCL2 associated agonist of cell death. (150 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
MYH6Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
MYH7Myosin-7-like. (1896 aa)
LOC101315484LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (613 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
CALML6Calmodulin-like protein 6. (179 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
NPPAAtrial natriuretic peptide. (177 aa)
NPPBNatriuretic peptides B. (127 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
ATP2B3ATPase plasma membrane Ca2+ transporting 3. (1218 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
NPR2Guanylate cyclase. (1047 aa)
GATA4Transcription factor GATA-4 isoform X2. (442 aa)
CALM2Calmodulin 2. (148 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (277 aa)
MYH15LOW QUALITY PROTEIN: myosin-15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1872 aa)
GNA11G protein subunit alpha 11. (359 aa)
PPP3CCSerine/threonine-protein phosphatase. (535 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (320 aa)
ADRA1Balpha-1B adrenergic receptor. (395 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1378 aa)
PPP1CAProtein phosphatase 1 catalytic subunit alpha. (321 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (749 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S-like. (1856 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (271 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
GTF2IGeneral transcription factor II-I isoform X5. (999 aa)
ENSTTRP00000013721annotation not available (118 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1071 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1041 aa)
NPR1Natriuretic peptide receptor 1. (1055 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (293 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ENSTTRP00000014640annotation not available (143 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
MYH1LOW QUALITY PROTEIN: myosin-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1807 aa)
LOC109548408Myosin-6. (1937 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X2. (498 aa)
ENSTTRP00000015063annotation not available (338 aa)
CALML4Calmodulin-like protein 4 isoform X2. (195 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1208 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (904 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha-1F isoform X1. (1973 aa)
KCNJ8Potassium inwardly rectifying channel subfamily J member 8. (424 aa)
RHOATransforming protein RhoA. (193 aa)
ENSTTRP00000016529annotation not available (169 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
Server load: low (40%) [HD]