STRINGSTRING
LOC101330472 LOC101330472 PLCB2 PLCB2 GRK3 GRK3 ADCY5 ADCY5 AKT2 AKT2 GNG5 GNG5 CCL26 CCL26 CCL24 CCL24 RAC2 RAC2 CXCR6 CXCR6 XCR1 XCR1 STAT1 STAT1 BCAR1 BCAR1 GNAI3 GNAI3 GNB4 GNB4 RAC3 RAC3 CCL25 CCL25 GRK2 GRK2 DOCK2 DOCK2 IKBKB IKBKB RELA RELA PRKCD PRKCD PTK2B PTK2B GNG3 GNG3 BRAF BRAF PLCG1 PLCG1 PRKCB PRKCB ADCY9 ADCY9 CXCR5 CXCR5 LPXN LPXN PIK3CD PIK3CD PIK3CG PIK3CG CX3CR1 CX3CR1 GNG8 GNG8 ITK ITK ENSTTRP00000003621 ENSTTRP00000003621 ENSTTRP00000003631 ENSTTRP00000003631 LOC101331937 LOC101331937 LOC101324400 LOC101324400 SOS2 SOS2 PREX1 PREX1 ADCY2 ADCY2 GNGT2 GNGT2 ENSTTRP00000004331 ENSTTRP00000004331 GNB5 GNB5 GRK1 GRK1 GNB3 GNB3 ERAS ERAS RAC1 RAC1 RAP1A RAP1A MAPK3 MAPK3 CXCL13 CXCL13 CCR8 CCR8 ENSTTRP00000005342 ENSTTRP00000005342 CCL27 CCL27 LOC109547378 LOC109547378 CCL19 CCL19 LOC101329111 LOC101329111 SRC SRC CDC42 CDC42 GNG2 GNG2 LOC101330180 LOC101330180 LOC109551711 LOC109551711 LOC101338910 LOC101338910 LOC101338296 LOC101338296 CCL16 CCL16 ENSTTRP00000005523 ENSTTRP00000005523 CCL5 CCL5 ARRB1 ARRB1 VAV1 VAV1 CXCL14 CXCL14 GNB2 GNB2 GNAI1 GNAI1 PIK3CB PIK3CB PIK3R6 PIK3R6 PIK3R5 PIK3R5 STAT5B STAT5B PLCG2 PLCG2 IKBKG IKBKG GNG7 GNG7 STAT2 STAT2 STAT3 STAT3 ARRB2 ARRB2 CXCL16 CXCL16 GNAI2 GNAI2 JAK3 JAK3 GNG4 GNG4 ARR3 ARR3 PIK3R3 PIK3R3 ROCK2 ROCK2 CCL20 CCL20 SHC3 SHC3 ENSTTRP00000012200 ENSTTRP00000012200 ENSTTRP00000012198 ENSTTRP00000012198 RUFY4 RUFY4 ELMO1 ELMO1 TIAM1 TIAM1 KRAS KRAS CXCL9 CXCL9 GRK7 GRK7 PRKCZ PRKCZ CHUK CHUK NFKBIB NFKBIB CCR10 CCR10 JAK2 JAK2 AKT3 AKT3 PRKACB PRKACB ADCY6 ADCY6 HRAS HRAS NFKB1 NFKB1 CCL13 CCL13 CCL1 CCL1 CXCR3 CXCR3 PREX2 PREX2 BAD BAD PLCB3 PLCB3 GNG13 GNG13 MAP2K1 MAP2K1 ENSTTRP00000009564 ENSTTRP00000009564 ENSTTRP00000009537 ENSTTRP00000009537 CX3CL1 CX3CL1 CCL22 CCL22 VAV3 VAV3 PTK2 PTK2 PLCB1 PLCB1 CCL28 CCL28 CCR9 CCR9 GRK6 GRK6 SHC4 SHC4 CEP152 CEP152 CRKL CRKL CXCL11 CXCL11 CXCL10 CXCL10 PARD3 PARD3 RASGRP2 RASGRP2 PAK1 PAK1 GNAQ GNAQ ADCY4 ADCY4 CXCL12 CXCL12 GSK3A GSK3A NFKBIA NFKBIA LOC101325672 LOC101325672 RHOA RHOA CCR5 CCR5 CCR2 CCR2 FOXO3 FOXO3 CCR7 CCR7 LYN LYN CCR4 CCR4 MAPK1 MAPK1 GSK3B GSK3B ENSTTRP00000015784 ENSTTRP00000015784 CRK CRK PIK3R1 PIK3R1 ENSTTRP00000015348 ENSTTRP00000015348 SHC1 SHC1 ENSTTRP00000015287 ENSTTRP00000015287 FGR FGR GNG11 GNG11 GNGT1 GNGT1 VAV2 VAV2 NCF1 NCF1 RAP1B RAP1B CSDE1 CSDE1 NRAS NRAS ROCK1 ROCK1 ADCY3 ADCY3 PTRHD1 PTRHD1 GNG12 GNG12 PRKACA PRKACA GRK5 GRK5 CCL11 CCL11 CCL2 CCL2 GRB2 GRB2 SOS1 SOS1 AKT1 AKT1 PIK3CA PIK3CA PLCB4 PLCB4 ADCY8 ADCY8 ADCY7 ADCY7 ADCY1 ADCY1 HCK HCK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101330472C-C motif chemokine. (94 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (533 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCL26C-C motif chemokine 26. (94 aa)
CCL24C-C motif chemokine 24. (119 aa)
RAC2Ras-related C3 botulinum toxin substrate 1. (192 aa)
CXCR6C-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
STAT1Signal transducer and activator of transcription. (720 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (863 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
RAC3Ras-related C3 botulinum toxin substrate 1 isoform X2. (192 aa)
CCL25C-C motif chemokine ligand 25. (152 aa)
GRK2G protein-coupled receptor kinase 2. (651 aa)
DOCK2Dedicator of cytokinesis protein 2 isoform X1; Belongs to the DOCK family. (1810 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (735 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
PRKCDProtein kinase C delta. (671 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (941 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X4. (757 aa)
PLCG1Phosphoinositide phospholipase C. (1290 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
CXCR5C-X-C motif chemokine receptor 5. (374 aa)
LPXNLeupaxin isoform X2; Belongs to the paxillin family. (386 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
CX3CR1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GNG8G protein subunit gamma 8. (70 aa)
ITKTyrosine-protein kinase. (620 aa)
ENSTTRP00000003621annotation not available (129 aa)
ENSTTRP00000003631annotation not available (113 aa)
LOC101331937C-X-C motif chemokine. (98 aa)
LOC101324400C-X-C motif chemokine. (104 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1303 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1653 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ENSTTRP00000004331annotation not available (458 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
GRK1Rhodopsin kinase. (329 aa)
GNB3G protein subunit beta 3. (340 aa)
ERASES cell expressed Ras. (233 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (199 aa)
RAP1ARas-related protein Rap-1A isoform X1. (184 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
CXCL13C-X-C motif chemokine 13. (104 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ENSTTRP00000005342annotation not available (699 aa)
CCL27LOW QUALITY PROTEIN: C-C motif chemokine 27. (112 aa)
LOC109547378Uncharacterized protein LOC109547378. (110 aa)
CCL19C-C motif chemokine ligand 19. (109 aa)
LOC101329111C-C motif chemokine 21 isoform X2. (72 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
CDC42Cell division control protein 42 homolog. (156 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
LOC101330180C-C motif chemokine. (93 aa)
LOC109551711C-C motif chemokine. (63 aa)
LOC101338910C-C motif chemokine. (124 aa)
LOC101338296C-C motif chemokine. (96 aa)
CCL16C-C motif chemokine. (118 aa)
ENSTTRP00000005523annotation not available (722 aa)
CCL5C-C motif chemokine. (91 aa)
ARRB1Beta-arrestin-1. (417 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CXCL14C-X-C motif chemokine 14 isoform X2. (109 aa)
GNB2G protein subunit beta 2. (340 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (836 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PLCG2Phosphoinositide phospholipase C. (1264 aa)
IKBKGNF-kappa-B essential modulator. (424 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
ARRB2Arrestin beta 2. (382 aa)
CXCL16C-X-C motif chemokine 16. (260 aa)
GNAI2G protein subunit alpha i2. (351 aa)
JAK3Tyrosine-protein kinase JAK3. (1125 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ARR3arrestin-C. (390 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1378 aa)
CCL20C-C motif chemokine. (96 aa)
SHC3SHC-transforming protein 3. (539 aa)
ENSTTRP00000012200annotation not available (353 aa)
ENSTTRP00000012198annotation not available (354 aa)
RUFY4RUN and FYVE domain-containing protein 4. (606 aa)
ELMO1Engulfment and cell motility protein 1. (727 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X2. (1582 aa)
KRASGTPase KRas. (189 aa)
CXCL9C-X-C motif chemokine. (126 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (551 aa)
PRKCZProtein kinase C zeta. (592 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
NFKBIBNF-kappa-B inhibitor beta. (359 aa)
CCR10C-C motif chemokine receptor 10. (363 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
HRASGTPase HRas isoform X1. (189 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
CCL13C-C motif chemokine 13. (98 aa)
CCL1C-C motif chemokine 1. (96 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (411 aa)
PREX2Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X2. (1602 aa)
BADBCL2 associated agonist of cell death. (150 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
ENSTTRP00000009564annotation not available (110 aa)
ENSTTRP00000009537annotation not available (71 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (395 aa)
CCL22C-C motif chemokine. (93 aa)
VAV3Guanine nucleotide exchange factor VAV3. (846 aa)
PTK2Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1062 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
CCL28C-C motif chemokine. (127 aa)
CCR9C-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (589 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa. (1712 aa)
CRKLCrk-like protein. (303 aa)
CXCL11C-X-C motif chemokine 11. (95 aa)
CXCL10C-X-C motif chemokine. (92 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1281 aa)
RASGRP2RAS guanyl releasing protein 2. (665 aa)
PAK1Serine/threonine-protein kinase PAK 1. (550 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
CXCL12Stromal cell-derived factor 1 isoform X5; Belongs to the intercrine alpha (chemokine CxC) family. (138 aa)
GSK3AGlycogen synthase kinase-3 alpha. (483 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
LOC101325672Lymphotactin-like. (110 aa)
RHOATransforming protein RhoA. (193 aa)
CCR5C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCR2C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
FOXO3Forkhead box protein O3. (612 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (376 aa)
LYNTyrosine-protein kinase. (491 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
ENSTTRP00000015784annotation not available (149 aa)
CRKAdapter molecule crk isoform X4. (223 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
ENSTTRP00000015348annotation not available (321 aa)
SHC1SHC adaptor protein 1. (584 aa)
ENSTTRP00000015287annotation not available (555 aa)
FGRTyrosine-protein kinase. (418 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
NCF1Neutrophil cytosol factor 1. (340 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (53 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (635 aa)
CCL11C-C motif chemokine. (97 aa)
CCL2C-C motif chemokine. (99 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
HCKTyrosine-protein kinase. (524 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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