STRINGSTRING
F2R F2R CYTH3 CYTH3 PIP5K1A PIP5K1A PLCG2 PLCG2 ENSTTRP00000006413 ENSTTRP00000006413 GRM4 GRM4 PIK3R5 PIK3R5 PIK3R6 PIK3R6 PIK3CB PIK3CB MRAS MRAS AGPAT1 AGPAT1 ENSTTRP00000005523 ENSTTRP00000005523 PIP5K1C PIP5K1C MAPK3 MAPK3 RRAS RRAS PLD1 PLD1 RHEBL1 RHEBL1 ERAS ERAS EGF EGF DGKD DGKD ADCY2 ADCY2 LPAR6 LPAR6 SOS2 SOS2 AGT AGT ENSTTRP00000003621 ENSTTRP00000003621 GNA12 GNA12 PLPP2 PLPP2 ARF6 ARF6 SYK SYK PIK3CG PIK3CG CYTH1 CYTH1 PIK3CD PIK3CD GRM5 GRM5 GAB1 GAB1 F2 F2 DGKG DGKG ADCY9 ADCY9 PLCG1 PLCG1 PDGFA PDGFA PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLA2G4E PLA2G4E GRM8 GRM8 LOC101320351 LOC101320351 RALB RALB PTK2B PTK2B LPAR3 LPAR3 AVPR1A AVPR1A GRM2 GRM2 MTOR MTOR PDGFB PDGFB AKT2 AKT2 ADCY5 ADCY5 PLD2 PLD2 ZNF408 ZNF408 DGKI DGKI PLCB2 PLCB2 RAPGEF3 RAPGEF3 RHOA RHOA EGFR EGFR AGPAT5 AGPAT5 RHEB RHEB DNM3 DNM3 MAPK1 MAPK1 GRM7 GRM7 KITLG KITLG ENSTTRP00000015784 ENSTTRP00000015784 DNM2 DNM2 PLA2G4A PLA2G4A DGKZ DGKZ DNM1 DNM1 ENSTTRP00000015396 ENSTTRP00000015396 PTK6 PTK6 PIK3R1 PIK3R1 SHC1 SHC1 ENSTTRP00000015287 ENSTTRP00000015287 PLPP3 PLPP3 GNAS GNAS SPHK1 SPHK1 AVPR1B AVPR1B TSC2 TSC2 CSDE1 CSDE1 NRAS NRAS ENSTTRP00000014640 ENSTTRP00000014640 KIT KIT FCER1A FCER1A ADCY3 ADCY3 PTRHD1 PTRHD1 DGKA DGKA PDGFD PDGFD PDGFRB PDGFRB GAB2 GAB2 PIP5K1B PIP5K1B FYN FYN LOC101318964 LOC101318964 GRB2 GRB2 TSC1 TSC1 SOS1 SOS1 AKT1 AKT1 ARF1 ARF1 PIK3CA PIK3CA PLCB4 PLCB4 GRM3 GRM3 ADCY8 ADCY8 DGKB DGKB ADCY7 ADCY7 ADCY1 ADCY1 ENSTTRP00000012558 ENSTTRP00000012558 PIK3R3 PIK3R3 SHC3 SHC3 GRM6 GRM6 ENSTTRP00000012200 ENSTTRP00000012200 ENSTTRP00000012198 ENSTTRP00000012198 RUFY4 RUFY4 KRAS KRAS PDGFRA PDGFRA AGPAT4 AGPAT4 ENSTTRP00000011347 ENSTTRP00000011347 RAPGEF4 RAPGEF4 AKT3 AKT3 ADCY6 ADCY6 DGKQ DGKQ AGPAT3 AGPAT3 PDGFC PDGFC HRAS HRAS RALA RALA DGKK DGKK RRAS2 RRAS2 PLCB3 PLCB3 MAP2K1 MAP2K1 GRM1 GRM1 LPAR2 LPAR2 PLCB1 PLCB1 AGTR1 AGTR1 MS4A2 MS4A2 SHC4 SHC4 CEP152 CEP152 ENSTTRP00000008884 ENSTTRP00000008884 PTGFR PTGFR GNA13 GNA13 FCER1G FCER1G INSR INSR DGKH DGKH PTPN11 PTPN11 ENSTTRP00000008549 ENSTTRP00000008549 DGKE DGKE LPAR1 LPAR1 PLPP1 PLPP1 ADCY4 ADCY4 PRKCA PRKCA CYTH2 CYTH2 AGPAT2 AGPAT2 AVPR2 AVPR2 CYTH4 CYTH4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F2RProteinase-activated receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
CYTH3Cytohesin-3. (296 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (553 aa)
PLCG2Phosphoinositide phospholipase C. (1264 aa)
ENSTTRP00000006413annotation not available (364 aa)
GRM4Glutamate metabotropic receptor 4. (912 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (836 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
MRASRas-related protein M-Ras. (175 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
ENSTTRP00000005523annotation not available (722 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (624 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
RRASRAS related. (218 aa)
PLD1Phospholipase. (1074 aa)
RHEBL1GTPase RhebL1 isoform X2. (183 aa)
ERASES cell expressed Ras. (233 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
DGKDDiacylglycerol kinase delta. (1210 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (347 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1303 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
ENSTTRP00000003621annotation not available (129 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (382 aa)
PLPP2Phospholipid phosphatase 2 isoform X1. (296 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (201 aa)
SYKTyrosine-protein kinase. (629 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
CYTH1Cytohesin-1 isoform X2. (415 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1199 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (700 aa)
F2Coagulation factor II, thrombin. (623 aa)
DGKGDiacylglycerol kinase. (790 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
PLCG1Phosphoinositide phospholipase C. (1290 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
PLA2G4FCytosolic phospholipase A2 zeta. (848 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLA2G4ECytosolic phospholipase A2 epsilon. (858 aa)
GRM8Metabotropic glutamate receptor 8-like. (907 aa)
LOC101320351Cytosolic phospholipase A2 beta isoform X1. (1010 aa)
RALBRas-related protein Ral-B isoform X2. (202 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (941 aa)
LPAR3Lysophosphatidic acid receptor 3 isoform X5; Belongs to the G-protein coupled receptor 1 family. (355 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
GRM2Metabotropic glutamate receptor 2. (1080 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
PLD2Phospholipase D2. (929 aa)
ZNF408Zinc finger protein 408 isoform X4. (719 aa)
DGKIDiacylglycerol kinase. (1065 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (923 aa)
RHOATransforming protein RhoA. (193 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
AGPAT51-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X4. (292 aa)
RHEBGTP-binding protein Rheb. (166 aa)
DNM3Dynamin-3 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (814 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
GRM7Metabotropic glutamate receptor 7. (924 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ENSTTRP00000015784annotation not available (149 aa)
DNM2Dynamin-2 isoform X4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
PLA2G4APhospholipase A2. (748 aa)
DGKZDiacylglycerol kinase zeta. (1118 aa)
DNM1Dynamin 1. (877 aa)
ENSTTRP00000015396annotation not available (256 aa)
PTK6Tyrosine-protein kinase. (425 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
SHC1SHC adaptor protein 1. (584 aa)
ENSTTRP00000015287annotation not available (555 aa)
PLPP3Phospholipid phosphatase 3 isoform X3. (312 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
SPHK1Sphingosine kinase 1 isoform X2. (473 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (355 aa)
TSC2Tuberin. (1815 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
ENSTTRP00000014640annotation not available (143 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha isoform X1. (261 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
DGKADiacylglycerol kinase. (706 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (368 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1102 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (686 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2. (492 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC101318964Ral guanine nucleotide dissociation stimulator. (926 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
TSC1Hamartin isoform X1. (1168 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
ARF1ADP-ribosylation factor 2 isoform X1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
GRM3Metabotropic glutamate receptor 3 isoform X1. (876 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
DGKBDiacylglycerol kinase. (804 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
ENSTTRP00000012558annotation not available (443 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SHC3SHC-transforming protein 3. (539 aa)
GRM6Glutamate metabotropic receptor 6. (889 aa)
ENSTTRP00000012200annotation not available (353 aa)
ENSTTRP00000012198annotation not available (354 aa)
RUFY4RUN and FYVE domain-containing protein 4. (606 aa)
KRASGTPase KRas. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1040 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2. (378 aa)
ENSTTRP00000011347annotation not available (185 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1012 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
DGKQDiacylglycerol kinase. (949 aa)
AGPAT31-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1. (375 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
HRASGTPase HRas isoform X1. (189 aa)
RALARas-related protein Ral-A isoform X1. (206 aa)
DGKKDiacylglycerol kinase. (1112 aa)
RRAS2Ras-related protein R-Ras2 isoform X2. (204 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1195 aa)
LPAR2Lysophosphatidic acid receptor 2. (351 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta. (242 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa. (1712 aa)
ENSTTRP00000008884annotation not available (287 aa)
PTGFRProstaglandin F2-alpha receptor. (359 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (282 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (66 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
DGKHDiacylglycerol kinase. (1218 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ENSTTRP00000008549annotation not available (48 aa)
DGKEDiacylglycerol kinase. (564 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PLPP1Phospholipid phosphatase 1 isoform X1. (359 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
CYTH2Cytohesin 2. (400 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase beta. (217 aa)
AVPR2Arginine vasopressin receptor 2. (370 aa)
CYTH4Cytohesin-4-like. (390 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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