STRINGSTRING
PIK3CB PIK3CB FAM76B FAM76B RPS6KA1 RPS6KA1 FZD4 FZD4 FZD3 FZD3 ENSTTRP00000005523 ENSTTRP00000005523 REM1 REM1 WNT4 WNT4 ENSTTRP00000005237 ENSTTRP00000005237 MAPK3 MAPK3 OXSR1 OXSR1 WNT5A WNT5A EIF4E3 EIF4E3 PDIK1L PDIK1L FAM76A FAM76A RHEBL1 RHEBL1 ERAS ERAS WNT1 WNT1 WNT10B WNT10B RNF152 RNF152 EIF4EBP1 EIF4EBP1 RPS6KA2 RPS6KA2 SEC13 SEC13 EIF4E EIF4E WNT8B WNT8B SOS2 SOS2 WDR24 WDR24 CAB39L CAB39L LIM2 LIM2 ENSTTRP00000003734 ENSTTRP00000003734 PRKAA2 PRKAA2 WNT3 WNT3 WNT9B WNT9B RRAGD RRAGD MYO9B MYO9B DVL3 DVL3 PIK3CD PIK3CD ENSTTRP00000002598 ENSTTRP00000002598 PRKCB PRKCB LPIN3 LPIN3 BRAF BRAF SLC3A2 SLC3A2 IKBKB IKBKB RPS6KA3 RPS6KA3 SESN2 SESN2 RPS6 RPS6 RASGEF1B RASGEF1B STRADA STRADA CASTOR1 CASTOR1 REM2 REM2 LOC109551780 LOC109551780 FZD10 FZD10 SLC7A5 SLC7A5 MTOR MTOR LAMTOR5 LAMTOR5 SLC16A4 SLC16A4 TBC1D7 TBC1D7 SGK1 SGK1 ENSTTRP00000000868 ENSTTRP00000000868 AKT2 AKT2 FZD7 FZD7 ULK1 ULK1 RPTOR RPTOR DEPTOR DEPTOR ENSTTRP00000000228 ENSTTRP00000000228 LOC101336559 LOC101336559 STK39 STK39 MAPKAP1 MAPKAP1 RHOA RHOA IGF1 IGF1 RPS6KB1 RPS6KB1 WNT5B WNT5B RHEB RHEB CRYGN CRYGN CNBD2 CNBD2 DVL1 DVL1 FNIP2 FNIP2 RPS6KA6 RPS6KA6 TTI1 TTI1 MAPK1 MAPK1 GSK3B GSK3B ENSTTRP00000015784 ENSTTRP00000015784 CRYBB3 CRYBB3 KIAA1671 KIAA1671 WNT7B WNT7B LRP5 LRP5 ENSTTRP00000015457 ENSTTRP00000015457 WNT16 WNT16 PIK3R1 PIK3R1 ATP6V1E1 ATP6V1E1 CLIP1 CLIP1 ATP6V1D ATP6V1D FZD6 FZD6 RASL11B RASL11B TSC2 TSC2 CSDE1 CSDE1 NRAS NRAS MTUS2 MTUS2 ENSTTRP00000014640 ENSTTRP00000014640 RASGEF1A RASGEF1A ATP6V1G1 ATP6V1G1 DDIT4L DDIT4L LAMTOR3 LAMTOR3 AKT1S1 AKT1S1 STK11 STK11 IGF1R IGF1R TNFRSF1A TNFRSF1A GRB2 GRB2 TSC1 TSC1 SOS1 SOS1 AKT1 AKT1 CAB39 CAB39 TNF TNF ATP6V1G2 ATP6V1G2 EIF4E1B EIF4E1B PIK3CA PIK3CA ATP6V1B2 ATP6V1B2 MIOS MIOS FNIP1 FNIP1 LAMTOR2 LAMTOR2 WNT11 WNT11 RPS6KB2 RPS6KB2 ATP6V1C1 ATP6V1C1 PIK3R3 PIK3R3 LPIN1 LPIN1 ATP6V1C2 ATP6V1C2 LRP6 LRP6 RRAGB RRAGB KRAS KRAS GEM GEM SEH1L SEH1L ATP6V1B1 ATP6V1B1 FZD1 FZD1 NPRL3 NPRL3 TELO2 TELO2 ATP6V1E2 ATP6V1E2 CHUK CHUK RICTOR RICTOR ATP6V1H ATP6V1H AKT3 AKT3 WNT7A WNT7A HRAS HRAS PRKCG PRKCG EIF4E2 EIF4E2 PRKAA1 PRKAA1 STK35 STK35 LAMTOR1 LAMTOR1 WNT2 WNT2 DEPDC5 DEPDC5 MAP2K1 MAP2K1 RRAD RRAD WNT10A WNT10A WNT6 WNT6 WNT2B WNT2B TSSK6 TSSK6 ATP6V1A ATP6V1A DVL2 DVL2 DDIT4 DDIT4 LOC101316645 LOC101316645 RRAGC RRAGC WNT8A WNT8A GRB14 GRB14 MYO9A MYO9A SLC38A9 SLC38A9 STRADB STRADB INSR INSR GRB10 GRB10 CLIP2 CLIP2 TSSK4 TSSK4 ATP6V1G3 ATP6V1G3 LPIN2 LPIN2 SKP2 SKP2 PDPK1 PDPK1 GRB7 GRB7 ENSTTRP00000007761 ENSTTRP00000007761 PRKCA PRKCA EIF4B EIF4B FLCN FLCN WDR59 WDR59 ULK2 ULK2 CEP192 CEP192 TBCA TBCA NPRL2 NPRL2 ENSTTRP00000006413 ENSTTRP00000006413 ENSTTRP00000006381 ENSTTRP00000006381 WNT9A WNT9A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
FAM76BProtein FAM76B isoform X1. (291 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (744 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ENSTTRP00000005523annotation not available (722 aa)
REM1GTP-binding protein REM 1. (298 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
ENSTTRP00000005237annotation not available (67 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
OXSR1Serine/threonine-protein kinase OSR1 isoform X1. (522 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
EIF4E3Eukaryotic translation initiation factor 4E type 3 isoform X2; Belongs to the eukaryotic initiation factor 4E family. (165 aa)
PDIK1LSerine/threonine-protein kinase PDIK1L; Belongs to the protein kinase superfamily. (341 aa)
FAM76AProtein FAM76A isoform X1. (306 aa)
RHEBL1GTPase RhebL1 isoform X2. (183 aa)
ERASES cell expressed Ras. (233 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RNF152E3 ubiquitin-protein ligase RNF152. (203 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
RPS6KA2Ribosomal protein S6 kinase A2. (757 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component. (367 aa)
EIF4EEukaryotic translation initiation factor 4E isoform X2; Belongs to the eukaryotic initiation factor 4E family. (211 aa)
WNT8BWnt family member 8B. (353 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1303 aa)
WDR24WD repeat-containing protein 24. (917 aa)
CAB39LCalcium-binding protein 39-like. (300 aa)
LIM2Lens intrinsic membrane protein 2. (214 aa)
ENSTTRP00000003734annotation not available (216 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BWnt family member 9B. (330 aa)
RRAGDRas-related GTP-binding protein D. (395 aa)
MYO9BUnconventional myosin-IXb. (1690 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (498 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
ENSTTRP00000002598annotation not available (608 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LPIN3Phosphatidate phosphatase LPIN3 isoform X5. (763 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X4. (757 aa)
SLC3A24F2 cell-surface antigen heavy chain isoform X2. (476 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (735 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SESN2Sestrin 2. (470 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (248 aa)
RASGEF1Bras-GEF domain-containing family member 1B isoform X3. (500 aa)
STRADALOW QUALITY PROTEIN: STE20-related kinase adapter protein alpha-like. (431 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (330 aa)
REM2RRAD and GEM like GTPase 2. (313 aa)
LOC109551780LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (346 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SLC7A5Putative L-type amino acid transporter 1-like protein MLAS. (505 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
LAMTOR5Ragulator complex protein LAMTOR5. (159 aa)
SLC16A4Monocarboxylate transporter 5. (449 aa)
TBC1D7TBC1 domain family member 7 isoform X1. (293 aa)
SGK1Non-specific serine/threonine protein kinase. (405 aa)
ENSTTRP00000000868annotation not available (294 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (544 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1050 aa)
RPTORRegulatory-associated protein of mTOR-like. (1324 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform X1. (408 aa)
ENSTTRP00000000228annotation not available (57 aa)
LOC101336559Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2. (90 aa)
STK39STE20/SPS1-related proline-alanine-rich protein kinase isoform X1. (538 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X2. (480 aa)
RHOATransforming protein RhoA. (193 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
WNT5BWnt family member 5B. (361 aa)
RHEBGTP-binding protein Rheb. (166 aa)
CRYGNGamma-crystallin N; Belongs to the beta/gamma-crystallin family. (156 aa)
CNBD2Cyclic nucleotide-binding domain-containing protein 2 isoform X7. (574 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
FNIP2Folliculin-interacting protein 2 isoform X8. (237 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
TTI1TELO2-interacting protein 1 homolog isoform X1. (1092 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
ENSTTRP00000015784annotation not available (149 aa)
CRYBB3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (211 aa)
KIAA1671Uncharacterized protein KIAA1671-like. (1798 aa)
WNT7BWnt family member 7B. (350 aa)
LRP5LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5. (1582 aa)
ENSTTRP00000015457annotation not available (403 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (130 aa)
CLIP1CAP-Gly domain-containing linker protein 1 isoform X1. (1437 aa)
ATP6V1DV-type proton ATPase subunit D isoform X1. (231 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (707 aa)
RASL11BRas-like protein family member 11B. (179 aa)
TSC2Tuberin. (1815 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
MTUS2Microtubule-associated tumor suppressor candidate 2. (1374 aa)
ENSTTRP00000014640annotation not available (143 aa)
RASGEF1ARasGEF domain family member 1A. (488 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
DDIT4LDNA damage-inducible transcript 4-like protein. (193 aa)
LAMTOR3Ragulator complex protein LAMTOR3 isoform X1. (100 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (229 aa)
STK11Serine/threonine-protein kinase STK11 isoform X3. (340 aa)
IGF1RTyrosine-protein kinase receptor. (1358 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (439 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
TSC1Hamartin isoform X1. (1168 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
CAB39Calcium-binding protein 39 isoform X1. (340 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B. (210 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
ATP6V1B2ATPase H+ transporting V1 subunit B2. (424 aa)
MIOSWD repeat-containing protein mio. (875 aa)
FNIP1Folliculin-interacting protein 1 isoform X2. (1160 aa)
LAMTOR2Ragulator complex protein LAMTOR2. (150 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (486 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (380 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform X1. (929 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
LRP6Low-density lipoprotein receptor-related protein 6. (1611 aa)
RRAGBRas-related GTP-binding protein A. (374 aa)
KRASGTPase KRas. (189 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
SEH1LNucleoporin SEH1 isoform X2; Belongs to the WD repeat SEC13 family. (386 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. (513 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
NPRL3Nitrogen permease regulator 3-like protein isoform X1. (569 aa)
TELO2Telomere length regulation protein TEL2 homolog. (824 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X2. (1636 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
HRASGTPase HRas isoform X1. (189 aa)
PRKCGProtein kinase C gamma type. (697 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
STK35Serine/threonine-protein kinase 35. (402 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
DEPDC5DEP domain-containing protein 5. (1593 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
WNT10AWnt family member 10A. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
TSSK6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (273 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (614 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X9. (736 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
LOC101316645LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like. (526 aa)
RRAGCRas-related GTP-binding protein C. (399 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
GRB14Growth factor receptor-bound protein 14 isoform X2. (540 aa)
MYO9AUnconventional myosin-IXa isoform X4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2547 aa)
SLC38A9Sodium-coupled neutral amino acid transporter 9. (561 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
GRB10Growth factor receptor-bound protein 10. (588 aa)
CLIP2CAP-Gly domain-containing linker protein 2-like. (1046 aa)
TSSK4Testis specific serine kinase 4. (334 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (123 aa)
LPIN2Phosphatidate phosphatase LPIN2 isoform X3. (885 aa)
SKP2S-phase kinase-associated protein 2 isoform X2. (441 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
GRB7Growth factor receptor bound protein 7. (532 aa)
ENSTTRP00000007761annotation not available (312 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
EIF4BEukaryotic translation initiation factor 4B isoform X1. (68 aa)
FLCNFolliculin isoform X2. (574 aa)
WDR59WD repeat-containing protein 59 isoform X3. (955 aa)
ULK2Serine/threonine-protein kinase ULK2 isoform X2. (1033 aa)
CEP192Centrosomal protein of 192 kDa isoform X2. (1919 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (133 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
ENSTTRP00000006413annotation not available (364 aa)
ENSTTRP00000006381annotation not available (382 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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