STRINGSTRING
PFKL PFKL PPP2R2A PPP2R2A PFKFB4 PFKFB4 CCND1 CCND1 FOXO3 FOXO3 IGF1 IGF1 RPS6KB1 RPS6KB1 CFTR CFTR PRKAG2 PRKAG2 RHEB RHEB PPP2CA PPP2CA ADIPOQ ADIPOQ CPT1A CPT1A PPARG PPARG CREB3L1 CREB3L1 LEPR LEPR SIRT1 SIRT1 PIK3R1 PIK3R1 PPP2R2C PPP2R2C PPP2R2B PPP2R2B CREB1 CREB1 PFKFB2 PFKFB2 TSC2 TSC2 PFKM PFKM ENSTTRP00000014640 ENSTTRP00000014640 MAP3K7 MAP3K7 CREB5 CREB5 PPP2R5A PPP2R5A PFKP PFKP SREBF1 SREBF1 AKT1S1 AKT1S1 STK11 STK11 IGF1R IGF1R RAB8A RAB8A TSC1 TSC1 CAMKK2 CAMKK2 AKT1 AKT1 CAB39 CAB39 LOC101326776 LOC101326776 PIK3CA PIK3CA CPT1B CPT1B LIPE LIPE RPS6KB2 RPS6KB2 PIK3R3 PIK3R3 HNF4A HNF4A FOXO1 FOXO1 CREB3 CREB3 SCD SCD G6PC G6PC AKT3 AKT3 CREB3L4 CREB3L4 CRTC2 CRTC2 ENSTTRP00000010425 ENSTTRP00000010425 PRKAA1 PRKAA1 EEF2K EEF2K PPP2R1B PPP2R1B G6PC3 G6PC3 RAB14 RAB14 PRKAB2 PRKAB2 GAREM2 GAREM2 RAB10 RAB10 ELAVL1 ELAVL1 CREB3L3 CREB3L3 PRKAG3 PRKAG3 SLC2A4 SLC2A4 RAB11B RAB11B HMGCR HMGCR RAB2A RAB2A FASN FASN STRADB STRADB INSR INSR ACACA ACACA PPP2R5B PPP2R5B ENSTTRP00000008430 ENSTTRP00000008430 MLYCD MLYCD PCK2 PCK2 PDPK1 PDPK1 PPP2R2D PPP2R2D PPP2R3C PPP2R3C TBC1D1 TBC1D1 SCD5 SCD5 PPP2R5D PPP2R5D EEF2 EEF2 PIK3CB PIK3CB ACACB ACACB ADIPOR1 ADIPOR1 FBP1 FBP1 FBP2 FBP2 G6PC2 G6PC2 NOSTRIN NOSTRIN ENSTTRP00000005523 ENSTTRP00000005523 CPT1C CPT1C PPARGC1A PPARGC1A CREB3L2 CREB3L2 ADRA1A ADRA1A RHEBL1 RHEBL1 PRKAG1 PRKAG1 PFKFB1 PFKFB1 ENSTTRP00000004328 ENSTTRP00000004328 PPP2R5C PPP2R5C EIF4EBP1 EIF4EBP1 LOC101323346 LOC101323346 CAB39L CAB39L CCNA1 CCNA1 PRKAA2 PRKAA2 GYS2 GYS2 PFKFB3 PFKFB3 PPP2R3A PPP2R3A PIK3CD PIK3CD PPP2R5E PPP2R5E STRADA STRADA LEP LEP CCNA2 CCNA2 PRKAB1 PRKAB1 MTOR MTOR GYS1 GYS1 AKT2 AKT2 PCK1 PCK1 ULK1 ULK1 RPTOR RPTOR LOC101325973 LOC101325973 PPP2R1A PPP2R1A PPP2CB PPP2CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PFKLATP-dependent 6-phosphofructokinase, liver type. (743 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (505 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1. (442 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
FOXO3Forkhead box protein O3. (612 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (568 aa)
RHEBGTP-binding protein Rheb. (166 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ADIPOQAdiponectin. (242 aa)
CPT1ALOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (726 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
LEPRLeptin receptor isoform X2. (1165 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (616 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (423 aa)
PPP2R2BProtein phosphatase 2 regulatory subunit Bbeta. (509 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X4. (507 aa)
TSC2Tuberin. (1815 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type isoform X1. (851 aa)
ENSTTRP00000014640annotation not available (143 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (778 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X1. (1171 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (229 aa)
STK11Serine/threonine-protein kinase STK11 isoform X3. (340 aa)
IGF1RTyrosine-protein kinase receptor. (1358 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
TSC1Hamartin isoform X1. (1168 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (597 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
CAB39Calcium-binding protein 39 isoform X1. (340 aa)
LOC101326776Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform isoform X2; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
LIPELipase E, hormone sensitive type. (1042 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (486 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (448 aa)
FOXO1Forkhead box protein O1. (538 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
SCDacyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
CRTC2CREB-regulated transcription coactivator 2 isoform X1. (672 aa)
ENSTTRP00000010425annotation not available (344 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
EEF2KEukaryotic elongation factor 2 kinase. (722 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (664 aa)
G6PC3LOW QUALITY PROTEIN: glucose-6-phosphatase 3-like. (346 aa)
RAB14Ras-related protein Rab-14 isoform X1. (215 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (247 aa)
GAREM2GRB2-associated and regulator of MAPK protein 2. (922 aa)
RAB10Ras-related protein Rab-10 isoform X1. (200 aa)
ELAVL1ELAV-like protein 1. (326 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (455 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (486 aa)
SLC2A4Solute carrier family 2 member 4. (505 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
RAB2ARas-related protein Rab-2A. (210 aa)
FASNFatty acid synthase. (2087 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
ACACAacetyl-CoA carboxylase 1 isoform X1. (2414 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa)
ENSTTRP00000008430annotation not available (252 aa)
MLYCDmalonyl-CoA decarboxylase, mitochondrial. (318 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (560 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2. (453 aa)
TBC1D1TBC1 domain family member 1 isoform X3. (1161 aa)
SCD5stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (333 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (599 aa)
EEF2Elongation factor 2. (858 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
ACACBacetyl-CoA carboxylase 2. (2474 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (276 aa)
FBP2Fructose-bisphosphatase 2. (339 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
NOSTRINNostrin isoform X1. (506 aa)
ENSTTRP00000005523annotation not available (722 aa)
CPT1CCarnitine O-palmitoyltransferase 1, brain isoform. (672 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (796 aa)
CREB3L2LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ADRA1Aalpha-1A adrenergic receptor. (423 aa)
RHEBL1GTPase RhebL1 isoform X2. (183 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X2. (356 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1. (471 aa)
ENSTTRP00000004328annotation not available (424 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (531 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
LOC101323346Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (491 aa)
CAB39LCalcium-binding protein 39-like. (300 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (464 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (526 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1147 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
PPP2R5EProtein phosphatase 2 regulatory subunit B'epsilon. (467 aa)
STRADALOW QUALITY PROTEIN: STE20-related kinase adapter protein alpha-like. (431 aa)
LEPLeptin. (167 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1 isoform X2. (270 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (721 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1050 aa)
RPTORRegulatory-associated protein of mTOR-like. (1324 aa)
LOC101325973Platelet glycoprotein 4-like isoform X1; Belongs to the CD36 family. (471 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
PPP2CBProtein phosphatase 2 catalytic subunit beta. (285 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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