STRINGSTRING
HAMP HAMP THBS1 THBS1 PPP2CB PPP2CB CDKN2B CDKN2B PKNOX2 PKNOX2 PPP2R1A PPP2R1A RGMA RGMA FMOD FMOD DCN DCN FBN3 FBN3 RBL1 RBL1 LTBP3 LTBP3 BMP2 BMP2 SMAD2 SMAD2 ACVR1B ACVR1B SMURF1 SMURF1 SMAD3 SMAD3 BAMBI BAMBI NODAL NODAL EP300 EP300 INHBA INHBA LDAH LDAH SMAD7 SMAD7 ANKFN1 ANKFN1 TGFBR2 TGFBR2 NBL1 NBL1 INTS8 INTS8 TFDP1 TFDP1 BMPR2 BMPR2 ACVR2B ACVR2B MAPK3 MAPK3 ID4 ID4 BMP5 BMP5 ID1 ID1 TGIF2 TGIF2 IFNG IFNG LTBP1 LTBP1 LTBP4 LTBP4 ACVR1 ACVR1 SMAD9 SMAD9 SMAD1 SMAD1 BMPR1A BMPR1A TGIF1 TGIF1 PITX3 PITX3 ID2 ID2 ZFYVE16 ZFYVE16 SMURF2 SMURF2 BMP4 BMP4 THSD4 THSD4 SP1 SP1 AMHR2 AMHR2 PKNOX1 PKNOX1 ENSTTRP00000009655 ENSTTRP00000009655 SMAD6 SMAD6 E2F4 E2F4 PPP2R1B PPP2R1B CHRD CHRD FSTL3 FSTL3 LOC101325454 LOC101325454 SMAD4 SMAD4 RBX1 RBX1 E2F5 E2F5 FST FST GDF6 GDF6 ENSTTRP00000011729 ENSTTRP00000011729 TGFB1 TGFB1 LTBP2 LTBP2 INHBC INHBC INHBE INHBE RPS6KB2 RPS6KB2 TGFB2 TGFB2 TGFBR1 TGFBR1 RGMB RGMB MATN4 MATN4 TNF TNF INHBB INHBB LOC101327238 LOC101327238 SNAPIN SNAPIN BMPR1B BMPR1B ROCK1 ROCK1 TGFB3 TGFB3 PITX2 PITX2 FBN1 FBN1 ACVR1C ACVR1C BMP7 BMP7 NEO1 NEO1 BMP6 BMP6 MATN2 MATN2 ID3 ID3 ZFYVE9 ZFYVE9 SMAD5 SMAD5 MYC MYC ADAMTSL4 ADAMTSL4 ACVR2A ACVR2A MAPK1 MAPK1 SKP1 SKP1 PPP2CA PPP2CA PITX1 PITX1 FBN2 FBN2 CREBBP CREBBP GDF5 GDF5 HJV HJV RPS6KB1 RPS6KB1 RHOA RHOA CUL1 CUL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAMPHepcidin antimicrobial peptide. (81 aa)
THBS1Thrombospondin-1. (1144 aa)
PPP2CBProtein phosphatase 2 catalytic subunit beta. (285 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (86 aa)
PKNOX2Homeobox protein PKNOX2. (472 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
RGMARepulsive guidance molecule A isoform X1. (450 aa)
FMODFibromodulin. (377 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
FBN3Fibrillin 3. (2775 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1067 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1301 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ACVR1BActivin A receptor type 1B. (504 aa)
SMURF1E3 ubiquitin-protein ligase. (738 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (234 aa)
NODALNodal homolog. (348 aa)
EP300Histone acetyltransferase p300. (2422 aa)
INHBAInhibin beta A chain. (421 aa)
LDAHLipid droplet-associated hydrolase isoform X1. (315 aa)
SMAD7Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
ANKFN1Ankyrin repeat and fibronectin type-III domain-containing protein 1. (763 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (579 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1 isoform X2. (211 aa)
INTS8Integrator complex subunit 8. (970 aa)
TFDP1Transcription factor. (410 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ACVR2BActivin A receptor type 2B. (511 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
ID4DNA-binding protein inhibitor ID-4 isoform X2. (161 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
TGIF2Homeobox protein TGIF2. (196 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1599 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1624 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
SMAD9Mothers against decapentaplegic homolog. (466 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
TGIF1Homeobox protein TGIF1 isoform X3. (363 aa)
PITX3Homeobox protein. (289 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16 isoform X2. (1545 aa)
SMURF2E3 ubiquitin-protein ligase. (648 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
THSD4Thrombospondin type-1 domain-containing protein 4. (1017 aa)
SP1Transcription factor Sp1. (784 aa)
AMHR2anti-Mullerian hormone receptor type 2. (576 aa)
PKNOX1Homeobox protein PKNOX1 isoform X1. (436 aa)
ENSTTRP00000009655annotation not available (318 aa)
SMAD6SMAD family member 6. (492 aa)
E2F4LOW QUALITY PROTEIN: transcription factor E2F4. (398 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (664 aa)
CHRDChordin. (908 aa)
FSTL3Follistatin like 3. (262 aa)
LOC101325454Bone morphogenetic protein 8B. (241 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (82 aa)
E2F5Transcription factor E2F5 isoform X2. (340 aa)
FSTFollistatin isoform X2. (343 aa)
GDF6Growth/differentiation factor 6. (458 aa)
ENSTTRP00000011729annotation not available (367 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1814 aa)
INHBCInhibin beta C chain. (247 aa)
INHBEInhibin subunit beta E. (351 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (486 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
RGMBRGM domain family member B. (587 aa)
MATN4Matrilin-4 isoform X4. (624 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
INHBBInhibin beta B chain. (407 aa)
LOC101327238Left-right determination factor. (201 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (88 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
PITX2Homeobox protein. (325 aa)
FBN1Fibrillin-1. (2826 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
NEO1Neogenin isoform X4. (1450 aa)
BMP6Bone morphogenetic protein 6. (304 aa)
MATN2Matrilin-2. (956 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1422 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ADAMTSL4ADAMTS-like protein 4 isoform X2. (1070 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PITX1Homeobox protein. (314 aa)
FBN2Fibrillin-2. (2776 aa)
CREBBPCREB-binding protein isoform X6. (2402 aa)
GDF5Growth/differentiation factor 5. (489 aa)
HJVHemojuvelin isoform X1. (426 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RHOATransforming protein RhoA. (193 aa)
CUL1Cullin-1; Belongs to the cullin family. (767 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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