STRINGSTRING
TGFBR1 TGFBR1 TMEM145 TMEM145 LIPE LIPE PLCB4 PLCB4 AKT1 AKT1 ITPR1 ITPR1 ENSTTRP00000013721 ENSTTRP00000013721 PRKACA PRKACA SNAPIN SNAPIN SLC8A3 SLC8A3 MYL2 MYL2 GNG12 GNG12 PTRHD1 PTRHD1 ADCY3 ADCY3 SPP1 SPP1 APLNR APLNR PLIN3 PLIN3 PLIN1 PLIN1 NRAS NRAS CSDE1 CSDE1 MYL3 MYL3 MEF2A MEF2A NOTCH3 NOTCH3 CDH1 CDH1 CALML4 CALML4 GNGT1 GNGT1 GNG11 GNG11 ENSTTRP00000015348 ENSTTRP00000015348 ENSTTRP00000015784 ENSTTRP00000015784 MAPK1 MAPK1 PRKAG2 PRKAG2 RPS6KB1 RPS6KB1 CCND1 CCND1 SPHK1 SPHK1 PLCB2 PLCB2 PIK3C3 PIK3C3 SLC9A1 SLC9A1 ADCY5 ADCY5 MYLK MYLK SERPINE1 SERPINE1 AKT2 AKT2 GNG5 GNG5 NOS3 NOS3 KLF2 KLF2 MEF2D MEF2D GABARAPL2 GABARAPL2 MTOR MTOR GNAI3 GNAI3 PRKAB1 PRKAB1 GNB4 GNB4 RPS6 RPS6 PLAT PLAT SLC8A2 SLC8A2 NOS2 NOS2 FBXO21 FBXO21 NOS1 NOS1 GNG3 GNG3 PIK3R4 PIK3R4 SMAD2 SMAD2 ADCY9 ADCY9 NOS2-2 NOS2-2 CCN2 CCN2 SMAD3 SMAD3 PIK3CG PIK3CG HDAC4 HDAC4 GNG8 GNG8 CALM3 CALM3 PDE3B PDE3B ITPR2 ITPR2 PRKAA2 PRKAA2 MYLK4 MYLK4 MEF2C MEF2C ACTA2 ACTA2 ADCY2 ADCY2 GNGT2 GNGT2 GNB5 GNB5 GNB3 GNB3 ERAS ERAS PRKAG1 PRKAG1 PPARGC1A PPARGC1A UCP2 UCP2 UCP3 UCP3 EGR1 EGR1 RRAS RRAS MAPK3 MAPK3 GNG2 GNG2 REM1 REM1 GNB2 GNB2 MRAS MRAS JAG1 JAG1 GNAI1 GNAI1 PIK3R6 PIK3R6 PIK3R5 PIK3R5 ENSTTRP00000006413 ENSTTRP00000006413 ITPR3 ITPR3 GNG7 GNG7 RYR3 RYR3 CAMK4 CAMK4 MEF2B MEF2B GNAI2 GNAI2 GNG4 GNG4 MYLK2 MYLK2 NRF1 NRF1 RYR2 RYR2 ADCY10 ADCY10 ADCY4 ADCY4 GNAQ GNAQ GABARAPL1 GABARAPL1 TFAM TFAM GNA13 GNA13 AGTR1 AGTR1 PLCB1 PLCB1 GABARAP GABARAP PRKAG3 PRKAG3 RRAD RRAD MAP2K1 MAP2K1 GNG13 GNG13 PLCB3 PLCB3 PRKAB2 PRKAB2 SLC8A1 SLC8A1 RRAS2 RRAS2 HDAC5 HDAC5 RYR1 RYR1 PRKAA1 PRKAA1 HRAS HRAS CALML6 CALML6 ADCY6 ADCY6 PRKACB PRKACB AKT3 AKT3 BECN1 BECN1 SMAD4 SMAD4 PRKCE PRKCE CALM2 CALM2 GEM GEM KRAS KRAS RPS6KB2 RPS6KB2 MYLK3 MYLK3 ADCY1 ADCY1 ADCY7 ADCY7 ADCY8 ADCY8 MYL4 MYL4 CALM1 CALM1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
TMEM145Transmembrane protein 145. (541 aa)
LIPELipase E, hormone sensitive type. (1042 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
ENSTTRP00000013721annotation not available (118 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (88 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (53 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
SPP1Osteopontin isoform X1. (301 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
PLIN3Perilipin-3. (436 aa)
PLIN1Perilipin 1. (517 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
MYL3Myosin light chain 3. (197 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X2. (498 aa)
NOTCH3Neurogenic locus notch homolog protein 3-like isoform X1. (2308 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
CALML4Calmodulin-like protein 4 isoform X2. (195 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ENSTTRP00000015348annotation not available (321 aa)
ENSTTRP00000015784annotation not available (149 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (568 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
SPHK1Sphingosine kinase 1 isoform X2. (473 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (885 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
MYLKMyosin light chain kinase. (1911 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NOS3Nitric oxide synthase 3. (1197 aa)
KLF2Krueppel-like factor 2. (353 aa)
MEF2DMyocyte enhancer factor 2D. (494 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1 isoform X2. (270 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (248 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
NOS2Nitric oxide synthase 2. (933 aa)
FBXO21F-box only protein 21 isoform X1. (627 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1466 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4 isoform X1. (1357 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
NOS2-2Nitric oxide synthase, inducible. (36 aa)
CCN2Connective tissue growth factor. (349 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
HDAC4Histone deacetylase 4. (1065 aa)
GNG8G protein subunit gamma 8. (70 aa)
CALM3Calmodulin 3. (148 aa)
PDE3BPhosphodiesterase. (1045 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MYLK4Myosin light chain kinase family member 4. (388 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
ACTA2Actin, aortic smooth muscle. (378 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
GNB3G protein subunit beta 3. (340 aa)
ERASES cell expressed Ras. (233 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X2. (356 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (796 aa)
UCP2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
UCP3Uncoupling protein 3. (308 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
RRASRAS related. (218 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
REM1GTP-binding protein REM 1. (298 aa)
GNB2G protein subunit beta 2. (340 aa)
MRASRas-related protein M-Ras. (175 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (836 aa)
ENSTTRP00000006413annotation not available (364 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3-like. (2669 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RYR3Ryanodine receptor 3 isoform X2. (4854 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
MEF2BMyocyte-specific enhancer factor 2B. (346 aa)
GNAI2G protein subunit alpha i2. (351 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MYLK2Myosin light chain kinase 2. (597 aa)
NRF1Nuclear respiratory factor 1 isoform X5. (520 aa)
RYR2Ryanodine receptor 2. (4945 aa)
ADCY10Adenylate cyclase type 10. (1613 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
TFAMTranscription factor A, mitochondrial. (242 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (282 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
GABARAPGABA type A receptor-associated protein. (80 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (486 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (247 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
RRAS2Ras-related protein R-Ras2 isoform X2. (204 aa)
HDAC5Histone deacetylase 5. (1157 aa)
RYR1Ryanodine receptor 1. (5021 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
HRASGTPase HRas isoform X1. (189 aa)
CALML6Calmodulin-like protein 6. (179 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
BECN1Beclin-1 isoform X2. (448 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
CALM2Calmodulin 2. (148 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
KRASGTPase KRas. (189 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (486 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
MYL4Myosin light chain 4 isoform X1. (193 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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