STRINGSTRING
PLCB1 PLCB1 TUBA1B TUBA1B TUBB1-2 TUBB1-2 MAPK3 MAPK3 SRC SRC LOC101339365 LOC101339365 REM1 REM1 TUBB2A TUBB2A TUBB2B TUBB2B GNAI1 GNAI1 ENSTTRP00000006413 ENSTTRP00000006413 ITPR3 ITPR3 DRD2 DRD2 GNAI2 GNAI2 TUBB4A TUBB4A PRKCA PRKCA TUBB TUBB TUBB1 TUBB1 ADCY4 ADCY4 GNAQ GNAQ LPAR1 LPAR1 LOC101330624 LOC101330624 ENSTTRP00000008708 ENSTTRP00000008708 CSNK1D CSNK1D GRM1 GRM1 TUBA4A TUBA4A ENSTTRP00000009525 ENSTTRP00000009525 RRAD RRAD MAP2K1 MAP2K1 PLCB3 PLCB3 LOC101315484 LOC101315484 PRKCG PRKCG HRAS HRAS PDGFC PDGFC ADCY6 ADCY6 PRKACB PRKACB DRD1 DRD1 GNA11 GNA11 PDGFRA PDGFRA GEM GEM KRAS KRAS ADCY1 ADCY1 ADCY7 ADCY7 ADCY8 ADCY8 GUCY1A2 GUCY1A2 PLCB4 PLCB4 SOS1 SOS1 GRB2 GRB2 ITPR1 ITPR1 TUBAL3 TUBAL3 PDGFRB PDGFRB PRKACA PRKACA TJP1 TJP1 GJD2 GJD2 PDGFD PDGFD PTRHD1 PTRHD1 ADCY3 ADCY3 TUBB4B TUBB4B NRAS NRAS CSDE1 CSDE1 GJA1 GJA1 GNAS GNAS HTR2B HTR2B ENSTTRP00000015784 ENSTTRP00000015784 MAPK1 MAPK1 MAP3K2 MAP3K2 EGFR EGFR ITPR2 ITPR2 PRKG1 PRKG1 MAP2K5 MAP2K5 GRM5 GRM5 ADCY9 ADCY9 PRKCB PRKCB HTR2A HTR2A PDGFA PDGFA GNAI3 GNAI3 PDGFB PDGFB CDK1 CDK1 GUCY1B1 GUCY1B1 GUCY1A1 GUCY1A1 ADCY5 ADCY5 HTR2C HTR2C PLCB2 PLCB2 TUBB6 TUBB6 PRKG2 PRKG2 SOS2 SOS2 ADCY2 ADCY2 ADRB1 ADRB1 ENSTTRP00000004289 ENSTTRP00000004289 EGF EGF ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
TUBB1-2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (774 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
LOC101339365LOW QUALITY PROTEIN: tubulin alpha chain-like. (450 aa)
REM1GTP-binding protein REM 1. (298 aa)
TUBB2ATubulin beta 2A class IIa. (426 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
ENSTTRP00000006413annotation not available (364 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3-like. (2669 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (445 aa)
GNAI2G protein subunit alpha i2. (351 aa)
TUBB4ATubulin beta 4A class IVa. (443 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
TUBBTubulin beta class I. (444 aa)
TUBB1Tubulin beta 1 class VI. (449 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
LOC101330624Tubulin beta chain-like isoform X2; Belongs to the tubulin family. (346 aa)
ENSTTRP00000008708annotation not available (154 aa)
CSNK1DCasein kinase I; Belongs to the protein kinase superfamily. (415 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1195 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (369 aa)
ENSTTRP00000009525annotation not available (236 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
LOC101315484LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (613 aa)
PRKCGProtein kinase C gamma type. (697 aa)
HRASGTPase HRas isoform X1. (189 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GNA11G protein subunit alpha 11. (359 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1040 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
KRASGTPase KRas. (189 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (749 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1102 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
TJP1Tight junction protein ZO-1 isoform X4; Belongs to the MAGUK family. (1747 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (368 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
TUBB4BTubulin beta chain. (445 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
HTR2BLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B. (479 aa)
ENSTTRP00000015784annotation not available (149 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (559 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
PRKG1cGMP-dependent protein kinase 1; Belongs to the protein kinase superfamily. (686 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily. (448 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1199 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
CDK1Cyclin-dependent kinase 1 isoform X3; Belongs to the protein kinase superfamily. (301 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (610 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (684 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
HTR2C5-hydroxytryptamine receptor 2C. (457 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (426 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1303 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADRB1Beta-1 adrenergic receptor. (467 aa)
ENSTTRP00000004289annotation not available (448 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
Server load: low (32%) [HD]