STRINGSTRING
SMARCAD1 SMARCAD1 FZD7 FZD7 ENSTTRP00000000710 ENSTTRP00000000710 AKT2 AKT2 ESRRB ESRRB FZD10 FZD10 LIF LIF APC APC SKIL SKIL FGFR4 FGFR4 FGFR2 FGFR2 KAT6A KAT6A PAX6 PAX6 HOXD1 HOXD1 ZIC2 ZIC2 SMAD2 SMAD2 HAND1 HAND1 ACVR1B ACVR1B ZFHX3 ZFHX3 SMAD3 SMAD3 PIK3CD PIK3CD DVL3 DVL3 NODAL NODAL TBX3 TBX3 PCGF6 PCGF6 ZIC3 ZIC3 INHBA INHBA WNT3 WNT3 WNT9B WNT9B REST REST WNT8B WNT8B TCF3 TCF3 TBX2 TBX2 FGFR1 FGFR1 WNT10B WNT10B WNT1 WNT1 ERAS ERAS SOX2 SOX2 BMPR2 BMPR2 WNT5A WNT5A OTX1 OTX1 ACVR2B ACVR2B MAPK3 MAPK3 ENSTTRP00000005288 ENSTTRP00000005288 ID4 ID4 WNT4 WNT4 ID1 ID1 ENSTTRP00000005523 ENSTTRP00000005523 FZD3 FZD3 CTNNB1 CTNNB1 FZD4 FZD4 PRRX1 PRRX1 PIK3CB PIK3CB ENSTTRP00000006189 ENSTTRP00000006189 BMI1 BMI1 ENSTTRP00000006264 ENSTTRP00000006264 PCGF2 PCGF2 WNT9A WNT9A ENSTTRP00000006381 ENSTTRP00000006381 HOXA1 HOXA1 ENSTTRP00000006413 ENSTTRP00000006413 SETDB1 SETDB1 STAT3 STAT3 DLX5 DLX5 ACVR1 ACVR1 JAK3 JAK3 SMAD9 SMAD9 SMAD1 SMAD1 BMPR1A BMPR1A ENSTTRP00000007731 ENSTTRP00000007731 ID2 ID2 LHX1 LHX1 AXIN1 AXIN1 HESX1 HESX1 BMP4 BMP4 AXIN2 AXIN2 WNT8A WNT8A JAK1 JAK1 DVL2 DVL2 WNT2B WNT2B WNT6 WNT6 WNT10A WNT10A MAP2K1 MAP2K1 WNT2 WNT2 KLF4-2 KLF4-2 LOC101333926 LOC101333926 ISL1 ISL1 FGFR1-2 FGFR1-2 HRAS HRAS WNT7A WNT7A RIF1 RIF1 AKT3 AKT3 ENSTTRP00000010878 ENSTTRP00000010878 JAK2 JAK2 LIFR LIFR DUSP9 DUSP9 SMAD4 SMAD4 PCGF3 PCGF3 FZD1 FZD1 HOXB1 HOXB1 MAPK12 MAPK12 MAPK11 MAPK11 ENSTTRP00000011729 ENSTTRP00000011729 KRAS KRAS PCGF1 PCGF1 ISL2 ISL2 ONECUT2 ONECUT2 INHBC INHBC INHBE INHBE PIK3R3 PIK3R3 WNT11 WNT11 ONECUT1 ONECUT1 PIK3CA PIK3CA NFIL3 NFIL3 JARID2 JARID2 INHBB INHBB AKT1 AKT1 ZIC1 ZIC1 APC2 APC2 MAPK14 MAPK14 MAPK13 MAPK13 GRB2 GRB2 LOC101327238 LOC101327238 MEIS2 MEIS2 MEIS1 MEIS1 IGF1R IGF1R MYF5 MYF5 PCGF5 PCGF5 BMPR1B BMPR1B KLF4 KLF4 NRAS NRAS ACVR1C ACVR1C CSDE1 CSDE1 FZD6 FZD6 IL6ST IL6ST ID3 ID3 PIK3R1 PIK3R1 WNT16 WNT16 SMAD5 SMAD5 MYC MYC ACVR2A ACVR2A WNT7B WNT7B ENSTTRP00000015784 ENSTTRP00000015784 GSK3B GSK3B ENSTTRP00000015833 ENSTTRP00000015833 MAPK1 MAPK1 TCF7 TCF7 DVL1 DVL1 WNT5B WNT5B IGF1 IGF1 ESRRG ESRRG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMARCAD1annotation not available (1002 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (544 aa)
ENSTTRP00000000710annotation not available (306 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
ESRRBSteroid hormone receptor ERR2. (499 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
LIFLeukemia inhibitory factor. (202 aa)
APCAdenomatous polyposis coli protein isoform X2. (2845 aa)
SKILSki-like protein isoform X1. (681 aa)
FGFR4Fibroblast growth factor receptor 4-like. (1012 aa)
FGFR2Fibroblast growth factor receptor. (811 aa)
KAT6ALysine acetyltransferase 6A. (2000 aa)
PAX6Paired box protein Pax-6. (436 aa)
HOXD1Homeobox protein Hox-D1. (326 aa)
ZIC2Zinc finger protein ZIC 2. (496 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
ACVR1BActivin A receptor type 1B. (504 aa)
ZFHX3Zinc finger homeobox protein 3-like. (3666 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (498 aa)
NODALNodal homolog. (348 aa)
TBX3T-box transcription factor TBX3. (742 aa)
PCGF6Polycomb group RING finger protein 6. (351 aa)
ZIC3Zinc finger protein ZIC 3 isoform X1. (462 aa)
INHBAInhibin beta A chain. (421 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BWnt family member 9B. (330 aa)
RESTRE1-silencing transcription factor. (656 aa)
WNT8BWnt family member 8B. (353 aa)
TCF3Transcription factor 3. (649 aa)
TBX2T-box transcription factor TBX2. (703 aa)
FGFR1Fibroblast growth factor receptor 1. (822 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ERASES cell expressed Ras. (233 aa)
SOX2Transcription factor SOX-2. (314 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
OTX1Homeobox protein OTX1. (355 aa)
ACVR2BActivin A receptor type 2B. (511 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
ENSTTRP00000005288annotation not available (229 aa)
ID4DNA-binding protein inhibitor ID-4 isoform X2. (161 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
ENSTTRP00000005523annotation not available (722 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CTNNB1Catenin beta-1. (781 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
PRRX1Paired mesoderm homeobox protein 1. (164 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
ENSTTRP00000006189annotation not available (225 aa)
BMI1Polycomb complex protein BMI-1 isoform X2. (326 aa)
ENSTTRP00000006264annotation not available (282 aa)
PCGF2Polycomb group ring finger 2. (338 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ENSTTRP00000006381annotation not available (382 aa)
HOXA1Homeobox A1. (332 aa)
ENSTTRP00000006413annotation not available (364 aa)
SETDB1Histone-lysine N-methyltransferase SETDB1 isoform X2. (1282 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
DLX5Homeobox protein DLX-5. (289 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
JAK3Tyrosine-protein kinase JAK3. (1125 aa)
SMAD9Mothers against decapentaplegic homolog. (466 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
ENSTTRP00000007731annotation not available (287 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
AXIN1Axin-1 isoform X2. (866 aa)
HESX1Homeobox expressed in ES cells 1 isoform X1. (132 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
AXIN2Axin-2-like. (839 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X9. (736 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
WNT10AWnt family member 10A. (417 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
KLF4-2Krueppel-like factor 4 isoform X1. (441 aa)
LOC101333926RE1-silencing transcription factor-like. (974 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
FGFR1-2Fibroblast growth factor receptor 1. (692 aa)
HRASGTPase HRas isoform X1. (189 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
RIF1Telomere-associated protein RIF1. (2463 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
ENSTTRP00000010878annotation not available (263 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LIFRLeukemia inhibitory factor receptor. (1095 aa)
DUSP9Dual specificity phosphatase 9. (382 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
PCGF3Polycomb group RING finger protein 3 isoform X4. (242 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
HOXB1Homeobox B1. (298 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ENSTTRP00000011729annotation not available (367 aa)
KRASGTPase KRas. (189 aa)
PCGF1Polycomb group RING finger protein 1. (259 aa)
ISL2Insulin gene enhancer protein ISL-2. (324 aa)
ONECUT2One cut domain family member 2. (419 aa)
INHBCInhibin beta C chain. (247 aa)
INHBEInhibin subunit beta E. (351 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
ONECUT1One cut homeobox 1. (465 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
JARID2Protein Jumonji. (1235 aa)
INHBBInhibin beta B chain. (407 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
ZIC1Zinc finger protein ZIC 1. (447 aa)
APC2Adenomatous polyposis coli protein 2-like. (2262 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
LOC101327238Left-right determination factor. (201 aa)
MEIS2Homeobox protein Meis2 isoform X1. (345 aa)
MEIS1Homeobox protein Meis1 isoform X2. (463 aa)
IGF1RTyrosine-protein kinase receptor. (1358 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
PCGF5Polycomb group RING finger protein 5. (256 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
KLF4Transcription factor Sp5. (446 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (707 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
WNT7BWnt family member 7B. (350 aa)
ENSTTRP00000015784annotation not available (149 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
ENSTTRP00000015833annotation not available (280 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
TCF7Transcription factor 7. (480 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
WNT5BWnt family member 5B. (361 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
ESRRGEstrogen-related receptor gamma isoform X1. (458 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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