STRINGSTRING
RAC2 RAC2 RHOA RHOA MYLPF MYLPF ARHGAP5 ARHGAP5 ITGA4 ITGA4 PIK3R1 PIK3R1 VAV2 VAV2 NCF1 NCF1 RAP1B RAP1B AFDN AFDN CLDN10 CLDN10 CTNNA3 CTNNA3 ROCK1 ROCK1 CLDN5 CLDN5 MYL2 MYL2 CLDN11 CLDN11 NCF2 NCF2 MMP20 MMP20 ACTL8 ACTL8 VCAM1 VCAM1 MAPK13 MAPK13 MAPK14 MAPK14 XK XK PIK3CA PIK3CA CLDN17 CLDN17 ENSTTRP00000012558 ENSTTRP00000012558 ENSTTRP00000012550 ENSTTRP00000012550 PIK3R3 PIK3R3 ROCK2 ROCK2 CLDN4 CLDN4 RAPGEF3 RAPGEF3 ITGAM ITGAM ACTN1 ACTN1 MAPK11 MAPK11 MAPK12 MAPK12 MMP9 MMP9 RASSF5 RASSF5 RAPGEF4 RAPGEF4 CLDN16 CLDN16 CLDN1 CLDN1 ARHGAP35 ARHGAP35 EZR EZR CLDN9 CLDN9 CLDN6 CLDN6 CDH5 CDH5 PRKCG PRKCG ACTN4 ACTN4 CLDN14 CLDN14 ITGB1 ITGB1 VAV3 VAV3 PTK2 PTK2 CLDN7 CLDN7 ICAM1 ICAM1 F11R F11R PTPN11 PTPN11 NCF4 NCF4 CXCL12 CXCL12 CLDN3 CLDN3 VASP VASP MYL12B MYL12B MYL12A MYL12A PRKCA PRKCA XG XG CD99 CD99 GNAI2 GNAI2 CLDN18 CLDN18 PLCG2 PLCG2 CYBB CYBB CLDN24 CLDN24 PIK3CB PIK3CB GNAI1 GNAI1 ACTG1 ACTG1 CLDN20 CLDN20 CYBA CYBA VCL VCL CTNNB1 CTNNB1 MYL7 MYL7 VAV1 VAV1 MYL10 MYL10 ENSTTRP00000005523 ENSTTRP00000005523 CDC42 CDC42 ENSTTRP00000005342 ENSTTRP00000005342 THY1 THY1 RAP1A RAP1A RAC1 RAC1 PECAM1 PECAM1 CLDN15 CLDN15 GABPA GABPA JAM2 JAM2 NOXA1 NOXA1 ITK ITK TXK TXK PIK3CD PIK3CD LPXN LPXN MYL5 MYL5 MSN MSN OCLN OCLN RHOH RHOH PRKCB PRKCB PLCG1 PLCG1 CTNNA2 CTNNA2 PTK2B PTK2B JAM3 JAM3 SIPA1 SIPA1 CTNND1 CTNND1 ACTB ACTB ITGAL ITGAL GNAI3 GNAI3 MYL9 MYL9 CLDN19 CLDN19 CTNNA1 CTNNA1 BCAR1 BCAR1 MMP2 MMP2 ITGB2 ITGB2 CD99L2 CD99L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAC2Ras-related C3 botulinum toxin substrate 1. (192 aa)
RHOATransforming protein RhoA. (193 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform. (170 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1037 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
VAV2Vav guanine nucleotide exchange factor 2. (872 aa)
NCF1Neutrophil cytosol factor 1. (340 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
AFDNAfadin isoform X7. (1760 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
CTNNA3Catenin alpha-3. (895 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
CLDN5Claudin 5. (218 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (131 aa)
NCF2Neutrophil cytosol factor 2. (582 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (364 aa)
VCAM1Vascular cell adhesion protein 1. (739 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
XKXK-related protein. (376 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
ENSTTRP00000012558annotation not available (443 aa)
ENSTTRP00000012550annotation not available (285 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1378 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (923 aa)
ITGAMIntegrin alpha-M-like. (1139 aa)
ACTN1Alpha-actinin-1. (913 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MMP9Matrix metalloproteinase-9. (670 aa)
RASSF5Ras association domain-containing protein 5-like. (419 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1012 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (305 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ARHGAP35Rho GTPase-activating protein 35 isoform X1. (1510 aa)
EZREzrin isoform X1. (582 aa)
CLDN9Claudin 9. (217 aa)
CLDN6Claudin 6. (221 aa)
CDH5Cadherin-5. (779 aa)
PRKCGProtein kinase C gamma type. (697 aa)
ACTN4Actinin alpha 4. (911 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (786 aa)
VAV3Guanine nucleotide exchange factor VAV3. (846 aa)
PTK2Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1062 aa)
CLDN7Claudin 7. (209 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
F11RJunctional adhesion molecule A isoform X1. (298 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
NCF4Neutrophil cytosol factor 4. (270 aa)
CXCL12Stromal cell-derived factor 1 isoform X5; Belongs to the intercrine alpha (chemokine CxC) family. (138 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
VASPVasodilator-stimulated phosphoprotein. (406 aa)
MYL12BMyosin regulatory light chain 12B. (171 aa)
MYL12AMyosin regulatory light polypeptide 9. (172 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
XGGlycoprotein Xg. (140 aa)
CD99CD99 antigen isoform X2. (180 aa)
GNAI2G protein subunit alpha i2. (351 aa)
CLDN18Claudin 18. (261 aa)
PLCG2Phosphoinositide phospholipase C. (1264 aa)
CYBBCytochrome b-245 heavy chain. (570 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (205 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide; Belongs to the p22phox family. (192 aa)
VCLVinculin isoform X3. (1100 aa)
CTNNB1Catenin beta-1. (781 aa)
MYL7Myosin light chain 7. (141 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
MYL10Myosin light chain 10. (117 aa)
ENSTTRP00000005523annotation not available (722 aa)
CDC42Cell division control protein 42 homolog. (156 aa)
ENSTTRP00000005342annotation not available (699 aa)
THY1Thy-1 cell surface antigen. (161 aa)
RAP1ARas-related protein Rap-1A isoform X1. (184 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (199 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X2. (420 aa)
CLDN15Claudin-15. (227 aa)
GABPAGA-binding protein alpha chain. (454 aa)
JAM2Junctional adhesion molecule 2. (265 aa)
NOXA1NADPH oxidase activator 1. (465 aa)
ITKTyrosine-protein kinase. (620 aa)
TXKTyrosine-protein kinase. (525 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
LPXNLeupaxin isoform X2; Belongs to the paxillin family. (386 aa)
MYL5Myosin light chain 5. (178 aa)
MSNMoesin. (576 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCG1Phosphoinositide phospholipase C. (1290 aa)
CTNNA2Catenin alpha-2 isoform X3. (918 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (941 aa)
JAM3Junctional adhesion molecule C. (332 aa)
SIPA1Signal-induced proliferation-associated 1. (1042 aa)
CTNND1Catenin delta-1 isoform X1. (964 aa)
ACTBActin beta. (375 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1141 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
CLDN19Claudin 19. (224 aa)
CTNNA1Catenin alpha-1 isoform X1. (924 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (863 aa)
MMP272 kDa type IV collagenase. (657 aa)
ITGB2Integrin beta. (750 aa)
CD99L2CD99 molecule like 2. (259 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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