STRINGSTRING
PLCB2 PLCB2 LOC101332449 LOC101332449 HTR2C HTR2C ADCY5 ADCY5 ENSTTRP00000000575 ENSTTRP00000000575 MAPK9 MAPK9 ASIC3 ASIC3 CAMK2D CAMK2D ASIC1 ASIC1 TRPV3 TRPV3 TRPV1 TRPV1 PRKCD PRKCD LOC101320351 LOC101320351 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F HTR2A HTR2A PLCG1 PLCG1 PRKCB PRKCB ADCY9 ADCY9 PIK3CD PIK3CD CALM3 CALM3 MAP2K6 MAP2K6 BDKRB2 BDKRB2 F2RL1 F2RL1 ITPR2 ITPR2 ADCY2 ADCY2 TRPM8 TRPM8 CYP2J2 CYP2J2 ENSTTRP00000004849 ENSTTRP00000004849 MAP2K3 MAP2K3 PLA2G6 PLA2G6 SRC SRC ENSTTRP00000005432 ENSTTRP00000005432 ENSTTRP00000005443 ENSTTRP00000005443 ENSTTRP00000005447 ENSTTRP00000005447 ENSTTRP00000005523 ENSTTRP00000005523 IL1R1 IL1R1 PIK3CB PIK3CB PLCG2 PLCG2 ITPR3 ITPR3 CAMK2B CAMK2B PRKCA PRKCA PPP1CB PPP1CB ADCY4 ADCY4 ALOX12 ALOX12 GNAQ GNAQ IL1RAP IL1RAP ENSTTRP00000008530 ENSTTRP00000008530 PLCB1 PLCB1 PLCB3 PLCB3 PTGER2 PTGER2 PTGER4 PTGER4 PRKCG PRKCG IL1B IL1B NGF NGF ASIC2 ASIC2 CALML6 CALML6 ADCY6 ADCY6 PRKACB PRKACB CYP2W1 CYP2W1 ASIC4 ASIC4 TRPV4 TRPV4 PRKCE PRKCE CALM2 CALM2 CAMK2G CAMK2G MAPK12 MAPK12 MAPK11 MAPK11 PIK3R3 PIK3R3 PRKCQ PRKCQ PPP1CA PPP1CA ADCY1 ADCY1 ADCY7 ADCY7 ADCY8 ADCY8 CALM1 CALM1 MAPK8 MAPK8 PRKCH PRKCH PLCB4 PLCB4 PIK3CA PIK3CA MAPK14 MAPK14 MAPK13 MAPK13 ITPR1 ITPR1 ENSTTRP00000013721 ENSTTRP00000013721 NTRK1 NTRK1 CAMK2A CAMK2A ARSI ARSI PRKACA PRKACA PPP1CC PPP1CC PTRHD1 PTRHD1 ADCY3 ADCY3 GNAS GNAS CALML4 CALML4 MAPK10 MAPK10 HTR2B HTR2B PIK3R1 PIK3R1 PLA2G4A PLA2G4A KNG1 KNG1 IGF1 IGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB2Phosphoinositide phospholipase C. (1184 aa)
LOC101332449Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
HTR2C5-hydroxytryptamine receptor 2C. (457 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
ENSTTRP00000000575annotation not available (325 aa)
MAPK9Mitogen-activated protein kinase 9. (424 aa)
ASIC3Acid sensing ion channel subunit 3. (529 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4; Belongs to the protein kinase superfamily. (498 aa)
ASIC1Acid-sensing ion channel 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa)
TRPV3Uncharacterized protein LOC109548613 isoform X2. (788 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (843 aa)
PRKCDProtein kinase C delta. (671 aa)
LOC101320351Cytosolic phospholipase A2 beta isoform X1. (1010 aa)
PLA2G4ECytosolic phospholipase A2 epsilon. (858 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLA2G4FCytosolic phospholipase A2 zeta. (848 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
PLCG1Phosphoinositide phospholipase C. (1290 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
CALM3Calmodulin 3. (148 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
F2RL1Proteinase-activated receptor 2. (397 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1103 aa)
CYP2J2Cytochrome P450 2J2 isoform X1; Belongs to the cytochrome P450 family. (461 aa)
ENSTTRP00000004849annotation not available (371 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (350 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X2. (784 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
ENSTTRP00000005432annotation not available (287 aa)
ENSTTRP00000005443annotation not available (370 aa)
ENSTTRP00000005447annotation not available (519 aa)
ENSTTRP00000005523annotation not available (722 aa)
IL1R1Interleukin-1 receptor type 1 isoform X2. (572 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PLCG2Phosphoinositide phospholipase C. (1264 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3-like. (2669 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (489 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type isoform X1. (663 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X1. (570 aa)
ENSTTRP00000008530annotation not available (224 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (357 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (484 aa)
PRKCGProtein kinase C gamma type. (697 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
ASIC2Acid-sensing ion channel 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (361 aa)
CALML6Calmodulin-like protein 6. (179 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CYP2W1LOW QUALITY PROTEIN: cytochrome P450 2W1; Belongs to the cytochrome P450 family. (483 aa)
ASIC4Acid sensing ion channel subunit family member 4. (663 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4-like. (591 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
CALM2Calmodulin 2. (148 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5. (535 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PPP1CAProtein phosphatase 1 catalytic subunit alpha. (321 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (635 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
ENSTTRP00000013721annotation not available (118 aa)
NTRK1High affinity nerve growth factor receptor isoform X2. (778 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (539 aa)
ARSIArylsulfatase I. (571 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (293 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
CALML4Calmodulin-like protein 4 isoform X2. (195 aa)
MAPK10Mitogen-activated protein kinase. (463 aa)
HTR2BLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B. (479 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
PLA2G4APhospholipase A2. (748 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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