STRINGSTRING
JUN JUN EGFR EGFR MAPK1 MAPK1 ENSTTRP00000015784 ENSTTRP00000015784 CREB3L1 CREB3L1 RXFP1 RXFP1 PIK3R1 PIK3R1 ENSTTRP00000015348 ENSTTRP00000015348 SHC1 SHC1 ENSTTRP00000015287 ENSTTRP00000015287 GNG11 GNG11 GNGT1 GNGT1 MAPK10 MAPK10 GNAS GNAS CREB1 CREB1 CSDE1 CSDE1 NRAS NRAS CREB5 CREB5 ADCY3 ADCY3 PTRHD1 PTRHD1 GNG12 GNG12 MFF MFF COL4A3 COL4A3 COL4A4 COL4A4 MMP20 MMP20 PRKACA PRKACA ATF4 ATF4 GRB2 GRB2 MAPK13 MAPK13 MAPK14 MAPK14 SOS1 SOS1 AKT1 AKT1 PIK3CA PIK3CA PLCB4 PLCB4 RXFP2 RXFP2 TGFBR1 TGFBR1 MAPK8 MAPK8 GNAO1 GNAO1 MMP1 MMP1 ADCY8 ADCY8 ADCY7 ADCY7 ADCY1 ADCY1 PIK3R3 PIK3R3 SHC3 SHC3 TGFB1 TGFB1 KRAS KRAS MAP2K4 MAP2K4 MAPK11 MAPK11 MAPK12 MAPK12 GNA15 GNA15 MMP9 MMP9 PRKCZ PRKCZ CREB3 CREB3 LOC101333923 LOC101333923 AKT3 AKT3 PRKACB PRKACB ADCY6 ADCY6 CREB3L4 CREB3L4 HRAS HRAS NFKB1 NFKB1 COL3A1 COL3A1 PLCB3 PLCB3 VEGFB VEGFB GNG13 GNG13 MAP2K1 MAP2K1 MAP2K7 MAP2K7 CREB3L3 CREB3L3 COL4A5 COL4A5 COL4A6 COL4A6 PLCB1 PLCB1 WDR78 WDR78 INSL5 INSL5 SHC4 SHC4 CEP152 CEP152 VEGFA VEGFA ADCY4 ADCY4 PRKCA PRKCA NFKBIA NFKBIA ARR3 ARR3 GNG4 GNG4 FOS FOS GNAI2 GNAI2 ARRB2 ARRB2 GNG7 GNG7 ENSTTRP00000006413 ENSTTRP00000006413 VEGFD VEGFD PIK3CB PIK3CB GNAI1 GNAI1 COL4A2 COL4A2 COL4A1 COL4A1 GNB2 GNB2 EDN1 EDN1 ATF6B ATF6B ARRB1 ARRB1 ENSTTRP00000005523 ENSTTRP00000005523 GNG2 GNG2 SRC SRC MAPK3 MAPK3 COL1A1 COL1A1 VEGFC VEGFC CREB3L2 CREB3L2 ERAS ERAS GNB3 GNB3 GNB5 GNB5 GNGT2 GNGT2 TGFBR2 TGFBR2 ADCY2 ADCY2 SOS2 SOS2 ACTA2 ACTA2 COL1A2 COL1A2 GNG8 GNG8 PIK3CD PIK3CD NOS2-2 NOS2-2 ADCY9 ADCY9 SMAD2 SMAD2 GNG3 GNG3 NOS1 NOS1 FBXO21 FBXO21 NOS2 NOS2 RELA RELA MMP13 MMP13 GNB4 GNB4 GNAI3 GNAI3 EDNRB EDNRB MMP2 MMP2 NOS3 NOS3 GNG5 GNG5 AKT2 AKT2 MAPK9 MAPK9 ADCY5 ADCY5 ATF2 ATF2 PLCB2 PLCB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JUNTranscription factor AP-1; Belongs to the bZIP family. (321 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
ENSTTRP00000015784annotation not available (149 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
RXFP1Relaxin receptor 1. (757 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
ENSTTRP00000015348annotation not available (321 aa)
SHC1SHC adaptor protein 1. (584 aa)
ENSTTRP00000015287annotation not available (555 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
MAPK10Mitogen-activated protein kinase. (463 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (53 aa)
MFFMitochondrial fission factor isoform X2. (342 aa)
COL4A3Collagen alpha-3(IV) chain. (1658 aa)
COL4A4Collagen alpha-4(IV) chain. (1684 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
RXFP2Relaxin receptor 2 isoform X1. (752 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GNAO1G protein subunit alpha o1. (354 aa)
MMP1Interstitial collagenase. (470 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SHC3SHC-transforming protein 3. (539 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
KRASGTPase KRas. (189 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (360 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GNA15G protein subunit alpha 15. (325 aa)
MMP9Matrix metalloproteinase-9. (670 aa)
PRKCZProtein kinase C zeta. (592 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
LOC101333923Prorelaxin isoform X1. (183 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
HRASGTPase HRas isoform X1. (189 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (172 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (455 aa)
COL4A5Collagen alpha-5(IV) chain isoform X1. (1690 aa)
COL4A6Collagen alpha-6(IV) chain. (1666 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
WDR78LOW QUALITY PROTEIN: WD repeat-containing protein 78. (849 aa)
INSL5Insulin-like peptide INSL5. (135 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa. (1712 aa)
VEGFAVascular endothelial growth factor A. (402 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
ARR3arrestin-C. (390 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
FOSProto-oncogene c-Fos. (374 aa)
GNAI2G protein subunit alpha i2. (351 aa)
ARRB2Arrestin beta 2. (382 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSTTRP00000006413annotation not available (364 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
COL4A2Collagen alpha-2(IV) chain. (1677 aa)
COL4A1Collagen alpha-1(IV) chain. (1666 aa)
GNB2G protein subunit beta 2. (340 aa)
EDN1Endothelin-1. (202 aa)
ATF6BActivating transcription factor 6 beta. (671 aa)
ARRB1Beta-arrestin-1. (417 aa)
ENSTTRP00000005523annotation not available (722 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
COL1A1Collagen type I alpha 1 chain. (1462 aa)
VEGFCVascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (420 aa)
CREB3L2LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ERASES cell expressed Ras. (233 aa)
GNB3G protein subunit beta 3. (340 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (579 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1303 aa)
ACTA2Actin, aortic smooth muscle. (378 aa)
COL1A2Collagen alpha-2(I) chain isoform X1. (1360 aa)
GNG8G protein subunit gamma 8. (70 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
NOS2-2Nitric oxide synthase, inducible. (36 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1466 aa)
FBXO21F-box only protein 21 isoform X1. (627 aa)
NOS2Nitric oxide synthase 2. (933 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
MMP13Collagenase 3. (438 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
GNAI3G protein subunit alpha i3. (354 aa)
EDNRBEndothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (530 aa)
MMP272 kDa type IV collagenase. (657 aa)
NOS3Nitric oxide synthase 3. (1197 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
MAPK9Mitogen-activated protein kinase 9. (424 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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