STRINGSTRING
ITPR1 ITPR1 NR5A1 NR5A1 CCND1 CCND1 EGFR EGFR WNT5B WNT5B DVL1 DVL1 CACNA1F CACNA1F TCF7 TCF7 USP8 USP8 MAPK1 MAPK1 GSK3B GSK3B CREB3L1 CREB3L1 WNT7B WNT7B MC2R MC2R LOC101319007 LOC101319007 WNT16 WNT16 E2F2 E2F2 GNAS GNAS FZD6 FZD6 CREB1 CREB1 RAP1B RAP1B CREB5 CREB5 ADCY3 ADCY3 PTRHD1 PTRHD1 CDKN1B CDKN1B CDK2 CDK2 RASD1 RASD1 NCEH1 NCEH1 PRKACA PRKACA ARSI ARSI CAMK2A CAMK2A KCNA2 KCNA2 ATF4 ATF4 APC2 APC2 ORAI1 ORAI1 PLCB4 PLCB4 CACNA1S CACNA1S CDKN1A CDKN1A ADCY8 ADCY8 WDR5B WDR5B ADCY7 ADCY7 ADCY1 ADCY1 WNT11 WNT11 AIP AIP CYP17A1 CYP17A1 ARMC5 ARMC5 GNA11 GNA11 CACNA1D CACNA1D FZD1 FZD1 CAMK2G CAMK2G AIPL1 AIPL1 CREB3 CREB3 FH FH CDK6 CDK6 PRKACB PRKACB ADCY6 ADCY6 WNT7A WNT7A CREB3L4 CREB3L4 KCNA1 KCNA1 WNT2 WNT2 PLCB3 PLCB3 KCNK3 KCNK3 MAP2K1 MAP2K1 CREB3L3 CREB3L3 E2F1 E2F1 WNT10A WNT10A WNT6 WNT6 WNT2B WNT2B KCNA10 KCNA10 DVL2 DVL2 PLCB1 PLCB1 SP1 SP1 WNT8A WNT8A LDLR LDLR AGTR1 AGTR1 PDE8B PDE8B AXIN2 AXIN2 CDKN2C CDKN2C AXIN1 AXIN1 KCNK2 KCNK2 ENSTTRP00000008594 ENSTTRP00000008594 E2F3 E2F3 TCF7L1 TCF7L1 MEN1 MEN1 GNAQ GNAQ ADCY4 ADCY4 CDK4 CDK4 CCNE1 CCNE1 LEF1 LEF1 CYP11A1 CYP11A1 CAMK2B CAMK2B GNAI2 GNAI2 MRAP MRAP PDE11A PDE11A ARNT ARNT KCNA4 KCNA4 ITPR3 ITPR3 AHR AHR ENSTTRP00000006413 ENSTTRP00000006413 ENSTTRP00000006381 ENSTTRP00000006381 WNT9A WNT9A RBBP5 RBBP5 POMC POMC GNAI1 GNAI1 FZD4 FZD4 CTNNB1 CTNNB1 PBX1 PBX1 ATF6B ATF6B CYP21A2 CYP21A2 FZD3 FZD3 WNT4 WNT4 MAPK3 MAPK3 WDR5 WDR5 WNT5A WNT5A RAP1A RAP1A CREB3L2 CREB3L2 KMT2D KMT2D WNT1 WNT1 WNT10B WNT10B CCNE2 CCNE2 STAR STAR ASH2L ASH2L CRH CRH ADCY2 ADCY2 KMT2A KMT2A RB1 RB1 WNT8B WNT8B PDE8A PDE8A AGT AGT WNT9B WNT9B ITPR2 ITPR2 WNT3 WNT3 DVL3 DVL3 CACNA1C CACNA1C NR4A1 NR4A1 ADCY9 ADCY9 BRAF BRAF TCF7L2 TCF7L2 APC APC GNAI3 GNAI3 FZD10 FZD10 SCARB1 SCARB1 CAMK2D CAMK2D CACNA1I CACNA1I FZD7 FZD7 ADCY5 ADCY5 ATF2 ATF2 CACNA1H CACNA1H CRHR2 CRHR2 LOC101316201 LOC101316201 CACNA1G CACNA1G CDKN2B CDKN2B LOC109549807 LOC109549807 PLCB2 PLCB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
WNT5BWnt family member 5B. (361 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha-1F isoform X1. (1973 aa)
TCF7Transcription factor 7. (480 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1117 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
WNT7BWnt family member 7B. (350 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
LOC1013190073 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (369 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
E2F2Transcription factor E2F2 isoform X1. (433 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (707 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (173 aa)
CDK2Cyclin dependent kinase 2. (298 aa)
RASD1Dexamethasone-induced Ras-related protein 1. (276 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (278 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
ARSIArylsulfatase I. (571 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (539 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
APC2Adenomatous polyposis coli protein 2-like. (2262 aa)
ORAI1Calcium release-activated calcium channel protein 1. (238 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S-like. (1856 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
WDR5BWD repeat domain 5B. (326 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
AIPAryl hydrocarbon receptor interacting protein. (303 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (508 aa)
ARMC5Armadillo repeat-containing protein 5-like. (777 aa)
GNA11G protein subunit alpha 11. (359 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5. (535 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1 isoform X3. (314 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
FHFumarate hydratase, mitochondrial. (504 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
KCNK3Potassium channel subfamily K member 3. (396 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (455 aa)
E2F1Transcription factor E2F1 isoform X1. (437 aa)
WNT10AWnt family member 10A. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (508 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X9. (736 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
SP1Transcription factor Sp1. (784 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LDLRLow-density lipoprotein receptor. (842 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PDE8BPhosphodiesterase. (885 aa)
AXIN2Axin-2-like. (839 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
AXIN1Axin-1 isoform X2. (866 aa)
KCNK2Potassium channel subfamily K member 2 isoform X1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
ENSTTRP00000008594annotation not available (430 aa)
E2F3Transcription factor E2F3. (334 aa)
TCF7L1Transcription factor 7-like 1. (441 aa)
MEN1Menin 1. (615 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (254 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (350 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (518 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (489 aa)
GNAI2G protein subunit alpha i2. (351 aa)
MRAPMelanocortin-2 receptor accessory protein. (174 aa)
PDE11APhosphodiesterase. (930 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X3. (845 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (656 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3-like. (2669 aa)
AHRAryl hydrocarbon receptor. (839 aa)
ENSTTRP00000006413annotation not available (364 aa)
ENSTTRP00000006381annotation not available (382 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RBBP5Retinoblastoma-binding protein 5 isoform X1. (528 aa)
POMCPro-opiomelanocortin. (259 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CTNNB1Catenin beta-1. (781 aa)
PBX1pre-B-cell leukemia transcription factor 1 isoform X2. (430 aa)
ATF6BActivating transcription factor 6 beta. (671 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2. (496 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
WDR5WD repeat-containing protein 5B. (334 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
RAP1ARas-related protein Rap-1A isoform X1. (184 aa)
CREB3L2LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
KMT2DHistone-lysine N-methyltransferase 2D. (4855 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
STARSteroidogenic acute regulatory protein, mitochondrial. (285 aa)
ASH2Lset1/Ash2 histone methyltransferase complex subunit ASH2. (628 aa)
CRHCorticoliberin. (193 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3820 aa)
RB1Retinoblastoma-associated protein. (922 aa)
WNT8BWnt family member 8B. (353 aa)
PDE8APhosphodiesterase. (830 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
WNT9BWnt family member 9B. (330 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (498 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha-1C-like. (2195 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (632 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X4. (757 aa)
TCF7L2Transcription factor 7-like 2 isoform X5. (639 aa)
APCAdenomatous polyposis coli protein isoform X2. (2845 aa)
GNAI3G protein subunit alpha i3. (354 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SCARB1Scavenger receptor class B member 1. (465 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4; Belongs to the protein kinase superfamily. (498 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2228 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (544 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
CRHR2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (403 aa)
LOC101316201Cytochrome P450 11B1, mitochondrial; Belongs to the cytochrome P450 family. (371 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha-1G. (2374 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (86 aa)
LOC109549807LOW QUALITY PROTEIN: uncharacterized protein LOC109549807. (169 aa)
PLCB2Phosphoinositide phospholipase C. (1184 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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