STRINGSTRING
PLCB2 PLCB2 GHRHR GHRHR ATF2 ATF2 ADCY5 ADCY5 SOCS3 SOCS3 MAPK9 MAPK9 AKT2 AKT2 STAT1 STAT1 BCAR1 BCAR1 MTOR MTOR GNAI3 GNAI3 POU1F1 POU1F1 GHRH GHRH IGFBP3 IGFBP3 PLCG1 PLCG1 PRKCB PRKCB ADCY9 ADCY9 CACNA1C CACNA1C PIK3CD PIK3CD SOCS2 SOCS2 EP300 EP300 MAP2K6 MAP2K6 SSTR1 SSTR1 JUNB JUNB ITPR2 ITPR2 SOS2 SOS2 ADCY2 ADCY2 ERAS ERAS CREB3L2 CREB3L2 SSTR2 SSTR2 MAP2K3 MAP2K3 MAPK3 MAPK3 ENSTTRP00000005523 ENSTTRP00000005523 SSTR5 SSTR5 ATF6B ATF6B GNAI1 GNAI1 PIK3CB PIK3CB STAT5B STAT5B ENSTTRP00000006413 ENSTTRP00000006413 PLCG2 PLCG2 ITPR3 ITPR3 GHR GHR STAT5A STAT5A STAT3 STAT3 GHRL GHRL GNAI2 GNAI2 FOS FOS PRKCA PRKCA ADCY10 ADCY10 ADCY4 ADCY4 GNAQ GNAQ ENSTTRP00000008430 ENSTTRP00000008430 CRKL CRKL CEP152 CEP152 SHC4 SHC4 PLCB1 PLCB1 PTK2 PTK2 CREB3L3 CREB3L3 MAP2K1 MAP2K1 PLCB3 PLCB3 PRKCG PRKCG HRAS HRAS CREB3L4 CREB3L4 MAP3K1 MAP3K1 ADCY6 ADCY6 PRKACB PRKACB AKT3 AKT3 IGFALS IGFALS JAK2 JAK2 CREB3 CREB3 CACNA1D CACNA1D GNA11 GNA11 MAPK12 MAPK12 MAPK11 MAPK11 MAP2K4 MAP2K4 KRAS KRAS SST SST SHC3 SHC3 GHSR GHSR PIK3R3 PIK3R3 ADCY1 ADCY1 ADCY7 ADCY7 ADCY8 ADCY8 MAPK8 MAPK8 CACNA1S CACNA1S PLCB4 PLCB4 PIK3CA PIK3CA AKT1 AKT1 SOS1 SOS1 MAPK14 MAPK14 MAPK13 MAPK13 GRB2 GRB2 ITPR1 ITPR1 ATF4 ATF4 PRKACA PRKACA PTRHD1 PTRHD1 ADCY3 ADCY3 CREB5 CREB5 NRAS NRAS CSDE1 CSDE1 CREB1 CREB1 GNAS GNAS MAPK10 MAPK10 ENSTTRP00000015287 ENSTTRP00000015287 SHC1 SHC1 PIK3R1 PIK3R1 CREB3L1 CREB3L1 CRK CRK ENSTTRP00000015784 ENSTTRP00000015784 GSK3B GSK3B MAPK1 MAPK1 CACNA1F CACNA1F CREBBP CREBBP IGF1 IGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB2Phosphoinositide phospholipase C. (1184 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (420 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
MAPK9Mitogen-activated protein kinase 9. (424 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
STAT1Signal transducer and activator of transcription. (720 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (863 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
GNAI3G protein subunit alpha i3. (354 aa)
POU1F1POU domain protein. (317 aa)
GHRHSomatoliberin isoform X2. (107 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (236 aa)
PLCG1Phosphoinositide phospholipase C. (1290 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1226 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha-1C-like. (2195 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (1049 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
EP300Histone acetyltransferase p300. (2422 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (390 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2697 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1303 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ERASES cell expressed Ras. (233 aa)
CREB3L2LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (350 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
ENSTTRP00000005523annotation not available (722 aa)
SSTR5Somatostatin receptor 5. (285 aa)
ATF6BActivating transcription factor 6 beta. (671 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
ENSTTRP00000006413annotation not available (364 aa)
PLCG2Phosphoinositide phospholipase C. (1264 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3-like. (2669 aa)
GHRGrowth hormone receptor. (640 aa)
STAT5ASignal transducer and activator of transcription 5A. (794 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
GHRLAppetite-regulating hormone. (117 aa)
GNAI2G protein subunit alpha i2. (351 aa)
FOSProto-oncogene c-Fos. (374 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
ADCY10Adenylate cyclase type 10. (1613 aa)
ADCY4Adenylate cyclase type 4; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1077 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (329 aa)
ENSTTRP00000008430annotation not available (252 aa)
CRKLCrk-like protein. (303 aa)
CEP152Centrosomal protein of 152 kDa. (1712 aa)
SHC4SHC-transforming protein 4. (630 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
PTK2Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1062 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (455 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
PLCB3Phosphoinositide phospholipase C. (1230 aa)
PRKCGProtein kinase C gamma type. (697 aa)
HRASGTPase HRas isoform X1. (189 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1469 aa)
ADCY6Adenylate cyclase 6. (1167 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (606 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
GNA11G protein subunit alpha 11. (359 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (360 aa)
KRASGTPase KRas. (189 aa)
SSTSomatostatin. (116 aa)
SHC3SHC-transforming protein 3. (539 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ADCY1Adenylate cyclase 1. (1088 aa)
ADCY7Adenylate cyclase type 7-like. (1080 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S-like. (1856 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1192 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1067 aa)
AKT1AKT serine/threonine kinase 1. (480 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
MAPK14Mitogen-activated protein kinase 14. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (139 aa)
ADCY3Adenylate cyclase type 3. (1141 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
MAPK10Mitogen-activated protein kinase. (463 aa)
ENSTTRP00000015287annotation not available (555 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (732 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
CRKAdapter molecule crk isoform X4. (223 aa)
ENSTTRP00000015784annotation not available (149 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha-1F isoform X1. (1973 aa)
CREBBPCREB-binding protein isoform X6. (2402 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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