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LOC101332449 LOC101332449 LOC101326611 LOC101326611 LOC101330510 LOC101330510 ATF2 ATF2 BDNF BDNF ADCY5 ADCY5 GRIN3A GRIN3A GNG5 GNG5 ABCF2 ABCF2 ZC2HC1A ZC2HC1A GNAI3 GNAI3 GRIN3B GRIN3B GNB4 GNB4 HDAC1 HDAC1 ADORA2B ADORA2B GRIN1 GRIN1 GNG3 GNG3 BRAF BRAF GRIN2C GRIN2C LOC101321822 LOC101321822 H2BC1 H2BC1 HDAC4 HDAC4 GNG8 GNG8 CALM3 CALM3 HDAC8 HDAC8 SLC6A3 SLC6A3 SOS2 SOS2 CRH CRH GNGT2 GNGT2 GNB5 GNB5 GNB3 GNB3 HDAC6 HDAC6 ERAS ERAS CREB3L2 CREB3L2 H2BC18 H2BC18 LOC101322931 LOC101322931 LOC101320102 LOC101320102 ENSTTRP00000004809 ENSTTRP00000004809 ENSTTRP00000004818 ENSTTRP00000004818 ENSTTRP00000004825 ENSTTRP00000004825 LOC101322350 LOC101322350 H2AC20 H2AC20 H2AC21 H2AC21 SLC18A2 SLC18A2 MAPK3 MAPK3 GNG2 GNG2 CAMKK1 CAMKK1 ATF6B ATF6B MACROH2A1 MACROH2A1 GNB2 GNB2 H2BU1 H2BU1 H2AW H2AW H3-4 H3-4 GNAI1 GNAI1 MACROH2A2 MACROH2A2 SLC29A1 SLC29A1 H2AZ2 H2AZ2 GNG7 GNG7 CAMK4 CAMK4 DRD2 DRD2 H2AJ H2AJ ENSTTRP00000006970 ENSTTRP00000006970 NPY NPY GNAI2 GNAI2 GNG4 GNG4 GRIN2D GRIN2D PPP1R1B PPP1R1B PPP1CB PPP1CB FOSB FOSB DDC DDC MAOA MAOA MAOB MAOB CEP152 CEP152 SHC4 SHC4 LOC101318745 LOC101318745 ARAF ARAF CREB3L3 CREB3L3 MAP2K1 MAP2K1 GNG13 GNG13 HDAC5 HDAC5 HRAS HRAS CREB3L4 CREB3L4 HDAC11 HDAC11 CALML6 CALML6 PRKACB PRKACB HAT1 HAT1 DRD1 DRD1 CREB3 CREB3 CALM2 CALM2 PKIA PKIA HDAC10 HDAC10 ENSTTRP00000011747 ENSTTRP00000011747 HDAC7 HDAC7 KRAS KRAS SHC3 SHC3 PPP1CA PPP1CA LOC101326611-2 LOC101326611-2 LOC101322612 LOC101322612 LOC101330510-2 LOC101330510-2 LOC101320102-2 LOC101320102-2 LOC101329634 LOC101329634 LOC101329341 LOC101329341 H2BC15 H2BC15 LOC101330780 LOC101330780 LOC101322612-2 LOC101322612-2 LOC101320102-3 LOC101320102-3 LOC101322612-3 LOC101322612-3 LOC101326611-3 LOC101326611-3 LOC101328760 LOC101328760 PDYN PDYN GNAO1 GNAO1 CALM1 CALM1 SLC18A1 SLC18A1 HDAC3 HDAC3 CAMKK2 CAMKK2 SOS1 SOS1 GRB2 GRB2 SLC29A2 SLC29A2 ENSTTRP00000013721 ENSTTRP00000013721 ATF4 ATF4 PRKACA PRKACA ADORA2A ADORA2A HDAC9 HDAC9 H2AZ1 H2AZ1 HDAC2 HDAC2 GNG12 GNG12 PPP1CC PPP1CC CREB5 CREB5 TH TH NRAS NRAS CSDE1 CSDE1 H2BC11 H2BC11 CREB1 CREB1 H2AC11 H2AC11 LOC101320102-4 LOC101320102-4 LOC101319223 LOC101319223 LOC109551486 LOC109551486 LOC101329540 LOC101329540 GNAS GNAS CALML4 CALML4 GRIN2A GRIN2A GNGT1 GNGT1 GNG11 GNG11 ENSTTRP00000015287 ENSTTRP00000015287 SHC1 SHC1 ENSTTRP00000015348 ENSTTRP00000015348 CREB3L1 CREB3L1 ENSTTRP00000015784 ENSTTRP00000015784 MAPK1 MAPK1 H1-1 H1-1 LOC101322612-4 LOC101322612-4 ENSTTRP00000015863 ENSTTRP00000015863 LOC101320102-5 LOC101320102-5 LOC101322612-5 LOC101322612-5 ENSTTRP00000015867 ENSTTRP00000015867 H2BC3 H2BC3 LOC101322612-6 LOC101322612-6 LOC101320102-6 LOC101320102-6 LOC101328661 LOC101328661 H2AC6 H2AC6 H1-4 H1-4 H2BC5 H2BC5 LOC101327496 LOC101327496 LOC101320102-7 LOC101320102-7 ENSTTRP00000015885 ENSTTRP00000015885 LOC101332610 LOC101332610 LOC101321474 LOC101321474 LOC101322612-7 LOC101322612-7 LOC101320102-8 LOC101320102-8 ENSTTRP00000015893 ENSTTRP00000015893 LOC101324611 LOC101324611 LOC101322612-8 LOC101322612-8 LOC101324906 LOC101324906 LOC101322612-9 LOC101322612-9 LOC101323719 LOC101323719 LOC101320102-9 LOC101320102-9 SLC29A3 SLC29A3 NTRK2 NTRK2 GRIN2B GRIN2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101332449Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
LOC101326611Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101330510Histone H2B; Belongs to the histone H2B family. (126 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (255 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1111 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ABCF2ATP-binding cassette sub-family F member 2. (636 aa)
ZC2HC1AZinc finger C2HC domain-containing protein 1A isoform X2. (263 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GRIN3BLOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B-like; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1027 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (315 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1-like. (954 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X4. (757 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C. (1222 aa)
LOC101321822Histone H2A; Belongs to the histone H2A family. (129 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
HDAC4Histone deacetylase 4. (1065 aa)
GNG8G protein subunit gamma 8. (70 aa)
CALM3Calmodulin 3. (148 aa)
HDAC8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (368 aa)
SLC6A3Solute carrier family 6 member 3. (617 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1303 aa)
CRHCorticoliberin. (193 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (395 aa)
GNB3G protein subunit beta 3. (340 aa)
HDAC6Histone deacetylase 6. (1141 aa)
ERASES cell expressed Ras. (233 aa)
CREB3L2LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101322931Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101320102Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSTTRP00000004809annotation not available (130 aa)
ENSTTRP00000004818annotation not available (130 aa)
ENSTTRP00000004825annotation not available (136 aa)
LOC101322350Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
SLC18A2Synaptic vesicular amine transporter. (515 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
CAMKK1Calcium/calmodulin-dependent protein kinase kinase 1. (534 aa)
ATF6BActivating transcription factor 6 beta. (671 aa)
MACROH2A1Histone H2A; Belongs to the histone H2A family. (372 aa)
GNB2G protein subunit beta 2. (340 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
SLC29A1Equilibrative nucleoside transporter 1. (367 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (125 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (445 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (103 aa)
ENSTTRP00000006970annotation not available (102 aa)
NPYPro-neuropeptide Y isoform X2. (97 aa)
GNAI2G protein subunit alpha i2. (351 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (1332 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (212 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
FOSBProtein fosB isoform X1. (341 aa)
DDCaromatic-L-amino-acid decarboxylase isoform X1. (480 aa)
MAOAAmine oxidase. (359 aa)
MAOBAmine oxidase. (555 aa)
CEP152Centrosomal protein of 152 kDa. (1712 aa)
SHC4SHC-transforming protein 4. (630 aa)
LOC101318745Histone H3.3-like. (136 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (609 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (455 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
HDAC5Histone deacetylase 5. (1157 aa)
HRASGTPase HRas isoform X1. (189 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
HDAC11Histone deacetylase 11 isoform X1. (347 aa)
CALML6Calmodulin-like protein 6. (179 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (365 aa)
CALM2Calmodulin 2. (148 aa)
PKIAcAMP-dependent protein kinase inhibitor alpha. (65 aa)
HDAC10Histone deacetylase 10. (671 aa)
ENSTTRP00000011747annotation not available (136 aa)
HDAC7Histone deacetylase 7. (983 aa)
KRASGTPase KRas. (189 aa)
SHC3SHC-transforming protein 3. (539 aa)
PPP1CAProtein phosphatase 1 catalytic subunit alpha. (321 aa)
LOC101326611-2Histone H2A type 1. (130 aa)
LOC101322612Uncharacterized protein LOC109551478; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
LOC101330510-2Histone H2B type 1-L-like. (126 aa)
LOC101320102-2Histone H4. (103 aa)
LOC101329634Histone H4. (103 aa)
LOC101329341Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101330780Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101322612-2Histone H3.1. (136 aa)
LOC101320102-3Histone H4. (103 aa)
LOC101322612-3Histone H3.1. (136 aa)
LOC101326611-3Histone H2A type 1. (130 aa)
LOC101328760Histone H2B; Belongs to the histone H2B family. (126 aa)
PDYNproenkephalin-B. (249 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (517 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (597 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
GRB2Growth factor receptor-bound protein 2. (156 aa)
SLC29A2Solute carrier family 29 member 2. (419 aa)
ENSTTRP00000013721annotation not available (118 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (351 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (411 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1065 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (122 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (583 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (53 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (293 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
THTyrosine hydroxylase. (507 aa)
NRASNRAS proto-oncogene, GTPase. (152 aa)
CSDE1Cold shock domain-containing protein E1. (813 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
H2AC11Histone H2A type 1. (130 aa)
LOC101320102-4Histone H4. (103 aa)
LOC101319223Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC109551486Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC101329540Histone H3; Belongs to the histone H3 family. (136 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
CALML4Calmodulin-like protein 4 isoform X2. (195 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A isoform X1. (1464 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ENSTTRP00000015287annotation not available (555 aa)
SHC1SHC adaptor protein 1. (584 aa)
ENSTTRP00000015348annotation not available (321 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
ENSTTRP00000015784annotation not available (149 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
H1-1Histone H1.1-like. (218 aa)
LOC101322612-4Histone H3.1. (136 aa)
ENSTTRP00000015863annotation not available (110 aa)
LOC101320102-5Histone H4. (103 aa)
LOC101322612-5Histone H3.1. (136 aa)
ENSTTRP00000015867annotation not available (130 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101322612-6Histone H3.1. (136 aa)
LOC101320102-6Histone H4. (103 aa)
LOC101328661Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
H1-4Histone H1.4. (219 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101327496Histone H2B type 1-L-like isoform X1; Belongs to the histone H2B family. (125 aa)
LOC101320102-7Histone H4. (103 aa)
ENSTTRP00000015885annotation not available (169 aa)
LOC101332610Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101321474Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101322612-7Histone H3.1. (136 aa)
LOC101320102-8Histone H4. (103 aa)
ENSTTRP00000015893annotation not available (99 aa)
LOC101324611Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC101322612-8Histone H3.1. (136 aa)
LOC101324906Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101322612-9Histone H3.1. (136 aa)
LOC101323719Histone H2B; Belongs to the histone H2B family. (125 aa)
LOC101320102-9Histone H4. (103 aa)
SLC29A3Equilibrative nucleoside transporter 3 isoform X1. (464 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1479 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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